Patents by Inventor Beatriz Dominguez

Beatriz Dominguez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF REDUCING AROMATIC NITRO COMPOUNDS
    Publication number: 20220042055
    Abstract: A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 10, 2022
    Inventors: Serena BISAGNI, Amin BORNADEL, Beatriz DOMINGUEZ, Jacques LEPAIH, Steven M. MENNEN, Ahir PUSHPANATH, Iustina SLABU, Jason TEDROW, Simon J. HEDLEY
  • METHOD OF REDUCING AROMATIC NITRO COMPOUNDS
    Publication number: 20220017452
    Abstract: Disclosed herein is a method of reducing an aromatic nitro compound. In some embodiments the method comprises the step of contacting an aromatic nitro compound with a catalyst, wherein, the catalyst comprises, a disproportionation agent, and a biocatalyst. Also disclosed is a biocatalyst for use in the method, use of a disproportionation agent, and a biocatalyst, as a catalyst for reducing an aromatic nitro compound, and a kit comprising a disproportionation agent, and a biocatalyst.
    Type: Application
    Filed: December 12, 2019
    Publication date: January 20, 2022
    Inventors: Serena BISAGNI, Amin BORNADEL, Beatriz DOMINGUEZ, Jacques LEPAIH, Ahir PUSHPANATH, Iustina SLABU, Jason TEDROW, Steven MENNEN, Simon HEDLEY
  • Catalyst and use thereof
    Patent number: 10927352
    Abstract: Use of a catalyst in a method of reducing a substrate, the method comprising contacting a substrate with a catalyst, optionally in the presence of a co-substrate, thereby to generate a reduced substrate. The catalyst is a polypeptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO: 7. In some methods, the substrate concentration is at least 50 mM.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 23, 2021
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Beatriz Dominguez, Ursula Schell, Christian Kratzer, Thomas Kalthoff
  • Catalyst and use thereof
    Patent number: 10927353
    Abstract: Use of a catalyst in a method of reducing a substrate, the method comprising contacting a substrate with a catalyst, optionally in the presence of a co-substrate, thereby to generate a reduced substrate. The catalyst is a polypeptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO: 1, SEQ ID NO: 7 or SEQ ID NO: 9. In the method the substrate concentration is at least 50 mM.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 23, 2021
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Beatriz Dominguez, Ursula Schell, Christian Kratzer, Thomas Kalthoff
  • Catalyst and use thereof
    Patent number: 10829743
    Abstract: Disclosed is a method that includes use of a catalyst in a method of reducing a substrate, the method including contacting a substrate with a catalyst, optionally in the presence of a co-substrate, thereby to generate a reduced substrate. The catalyst is a polypeptide including an amino acid sequence having at least 70% identity to SEQ ID NO: 1, SEQ ID NO: 7 or SEQ ID NO: 9. In the method the substrate concentration is at least 50 mM.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: November 10, 2020
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Beatriz Dominguez, Ursula Schell, Christian Kratzer, Thomas Kalthoff
  • Catalyst And Use Thereof
    Publication number: 20180362939
    Abstract: Use of a catalyst in a method of reducing a substrate, the method comprising contacting a substrate with a catalyst, optionally in the presence of a co-substrate, thereby to generate a reduced substrate. The catalyst is a polypeptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO: 1, SEQ ID NO: 7 or SEQ ID NO: 9. In the method the substrate concentration is at least 50 mM.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Inventors: Beatriz Dominguez, Ursula Schell, Christian Kratzer, Thomas Kalthoff
  • CATALYST AND USE THEREOF
    Publication number: 20170226485
    Abstract: Disclosed is a method that includes use of a catalyst in a method of reducing a substrate, the method including contacting a substrate with a catalyst, optionally in the presence of a co-substrate, thereby to generate a reduced substrate. The catalyst is a polypeptide including an amino acid sequence having at least 70% identity to SEQ ID NO: 1, SEQ ID NO: 7 or SEQ ID NO: 9.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 10, 2017
    Inventors: Beatriz DOMINGUEZ, Ursula SCHELL, Christian KRATZER, Thomas KALTHOFF
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20150284388
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: June 17, 2015
    Publication date: October 8, 2015
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • Processes and intermediates for producing azaindoles
    Patent number: 9090614
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: July 28, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20150099884
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • Processes and intermediates for producing azaindoles
    Patent number: 8946425
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: February 3, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jur{hacek over (c)}ík, Beatriz Dominguez Olmo
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20140309421
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: June 25, 2014
    Publication date: October 16, 2014
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis
    Patent number: 8859815
    Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: October 14, 2014
    Assignee: Bial-Portela & C.A., S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
  • Processes and intermediates for producing azaindoles
    Patent number: 8796453
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: August 5, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20130303764
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: July 12, 2013
    Publication date: November 14, 2013
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcik, Beatriz Dominguez Olmo
  • Processes and intermediates for producing azaindoles
    Patent number: 8513414
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: August 20, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcik, Beatriz Dominguez Olmo
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20130102782
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: July 3, 2012
    Publication date: April 25, 2013
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis
    Publication number: 20120077973
    Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Application
    Filed: December 7, 2011
    Publication date: March 29, 2012
    Applicant: BIAL - PORTELA & CA, S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
  • ORGANIC COMPOUNDS
    Publication number: 20100184998
    Abstract: The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds.
    Type: Application
    Filed: June 18, 2008
    Publication date: July 22, 2010
    Inventors: Beatriz Dominguez, Alan Dyke, William Hems, Christian Mathes, Anthony C. O'Sullivan, Gottfried Sedelmeier
  • Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis
    Patent number: 7667075
    Abstract: A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: February 23, 2010
    Assignee: Bial - Portela & CA, S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock