Patents by Inventor Bengang XING

Bengang XING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
    Patent number: 10294205
    Abstract: There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 21, 2019
    Assignee: Nanyang Technological University
    Inventors: Ata Abbas, Teck Peng Loh, Bengang Xing
  • ALLENAMIDE AS AN ORTHOGONAL HANDLE FOR SELECTIVE MODIFICATION OF CYSTEINE IN PEPTIDES AND PROTEINS
    Publication number: 20170029373
    Abstract: There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.
    Type: Application
    Filed: March 27, 2015
    Publication date: February 2, 2017
    Applicant: Nanyang Technological University
    Inventors: Ata Abbas, Teck Peng Loh, Bengang Xing
  • Methods and compounds for detecting beta-lactamase activity
    Patent number: 9476087
    Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilized on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: October 25, 2016
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Bengang Xing, Xianfeng Huang, Tingting Jiang, Rongrong Liu
  • METHODS AND COMPOUNDS FOR DETECTING BETA-LACTAMASE ACTIVITY
    Publication number: 20140322739
    Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilized on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.
    Type: Application
    Filed: July 8, 2014
    Publication date: October 30, 2014
    Inventors: Bengang Xing, Xianfeng Huang, Tingting Jiang, Rongrong Liu
  • Methods and compounds for detecting beta-lactamase activity
    Patent number: 8802387
    Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilised on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: August 12, 2014
    Assignee: Nanyang Technological University
    Inventors: Bengang Xing, Xianfeng Huang, Tingting Jiang, Rongrong Liu
  • Quinazolinone based fluorogenic probes
    Patent number: 8697714
    Abstract: The present invention relates to a compound of the general formula (I) useful in the determining the presence, amount or activity of an enzyme in living cells, a method of preparing said compounds and a kit thereof.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: April 15, 2014
    Assignee: Nanyang Technological University
    Inventors: Bengang Xing, Junxin Aw, Qing Shao, Yanmei Yang, Tingting Jiang, Chungyen Ang
  • QUINAZOLINONE BASED FLUOROGENIC PROBES
    Publication number: 20120288884
    Abstract: The present invention relates to a compound of the general formula (I) useful in the determining the presence, amount or activity of an enzyme in living cells, a method of preparing said compounds and a kit thereof.
    Type: Application
    Filed: July 28, 2011
    Publication date: November 15, 2012
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Bengang Xing, Junxin Aw, Qing Shao, Yanmei Yang, Tingting Jiang, Chungyen Ang
  • MULTIFUNCTIONAL GLYCOPEPTIDE ANTIBIOTIC DERIVATIVES FOR FLUORESCENT IMAGING AND PHOTOACTIVE ANTIMICROBIAL THERAPY
    Publication number: 20120172289
    Abstract: The present invention relates to a compound of formula (I) and compositions thereof, methods of their production as well as methods for treating bacterial infection.
    Type: Application
    Filed: December 28, 2011
    Publication date: July 5, 2012
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Bengang Xing, Tingting Jiang, Roushen Liew
  • METHODS AND COMPOUNDS FOR DETECTING BETA-LACTAMASE ACTIVITY
    Publication number: 20090275065
    Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z-R15, Z-A-Z-R16, Z-A-Z-R17, Z-A-Z-R18 or Z-G-N(R8)R9 is released that is immobilised on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.
    Type: Application
    Filed: April 30, 2008
    Publication date: November 5, 2009
    Inventors: Bengang XING, Xianfeng Huang, Tingting Jiang, Rongrong Liu