Patents by Inventor Benjamin Eithan Reubinoff

Benjamin Eithan Reubinoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130330821
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Application
    Filed: May 1, 2013
    Publication date: December 12, 2013
    Applicant: ES CELL INTERNATIONAL PTE LTD.
    Inventors: BENJAMIN EITHAN REUBINOFF, MARTIN Federick PERA, TAMIR BEN-HUR
  • Patent number: 8460931
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: June 11, 2013
    Assignee: ES Cell International PTE Ltd.
    Inventors: Benjamin Eithan Reubinoff, Martin Federick Pera, Tamir Ben-Hur
  • Publication number: 20120122211
    Abstract: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
    Type: Application
    Filed: January 30, 2012
    Publication date: May 17, 2012
    Applicant: ES Cell International PTE Ltd.
    Inventor: Benjamin Eithan REUBINOFF
  • Publication number: 20120122109
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Application
    Filed: January 31, 2012
    Publication date: May 17, 2012
    Applicant: ES Cell International PTE Ltd.
    Inventors: Benjamin Eithan REUBINOFF, Martin Federick Pera, Tamir Ben-Hur
  • Publication number: 20120115229
    Abstract: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Application
    Filed: April 28, 2011
    Publication date: May 10, 2012
    Applicant: ES CELL INTERNATIONAL PTE LTD.
    Inventors: BENJAMIN EITHAN REUBINOFF, MARTIN FREDERICK PERA, TAMIR BEN-HUR
  • Patent number: 8137969
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: March 20, 2012
    Assignee: ES Cell International PTE Ltd.
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur
  • Patent number: 8133730
    Abstract: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: March 13, 2012
    Assignee: ES Cell International PTE Ltd
    Inventor: Benjamin Eithan Reubinoff
  • Patent number: 7947498
    Abstract: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: May 24, 2011
    Assignee: ES Cell International PTE Ltd.
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur
  • Patent number: 7604992
    Abstract: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: October 20, 2009
    Assignee: ES Cell International PTE Ltd.
    Inventor: Benjamin Eithan Reubinoff
  • Publication number: 20090258421
    Abstract: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Application
    Filed: February 6, 2009
    Publication date: October 15, 2009
    Applicant: ES CELL INTERNATIONAL PTY LTD.
    Inventors: Benjamin Eithan REUBINOFF, Martin Frederick PERA, Tamir BEN-HUR
  • Publication number: 20090075373
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Application
    Filed: June 13, 2008
    Publication date: March 19, 2009
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur
  • Patent number: 7504257
    Abstract: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: March 17, 2009
    Assignee: ES Cell International PTE Ltd.
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur
  • Publication number: 20090004736
    Abstract: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.
    Type: Application
    Filed: June 6, 2008
    Publication date: January 1, 2009
    Applicant: ES CELL INTERNATIONAL PTE LTD.
    Inventor: Benjamin Eithan Reubinoff
  • Patent number: 7011828
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: March 14, 2006
    Assignee: ES Cell International Pte. Ltd.
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur
  • Patent number: 6875607
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation, production of differentiated cells and in particular the production of human embryonic stem cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells capable of giving rise to mature somatic cells and uses thereof. The present invention also provides a purified preparation of undifferentiated human embryonic stem cells capable of proliferation in vitro. Furthermore, the present invention provides a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell. There is also provided a committed progenitor cell capable of giving rise to mature somatic cells.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: April 5, 2005
    Assignee: ES Cell International Pte Ltd
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Chui-Yee Fong, Alan Osborne Trounson, Ariffeen Bongso
  • Publication number: 20020164308
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof.
    Type: Application
    Filed: October 4, 2001
    Publication date: November 7, 2002
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur
  • Publication number: 20020160509
    Abstract: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation, production of differentiated cells and in particular the production of human embryonic stem cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells capable of giving rise to mature somatic cells and uses thereof. The present invention also provides a purified preparation of undifferentiated human embryonic stem cells capable of proliferation in vitro. Furthermore, the present invention provides a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell. There is also provided a committed progenitor cell capable of giving rise to mature somatic cells.
    Type: Application
    Filed: March 5, 2002
    Publication date: October 31, 2002
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Chui-Yee Fong, Alan Osborne Trounson, Ariffeen Bongso
  • Publication number: 20020068045
    Abstract: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and the cells that are generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.
    Type: Application
    Filed: March 14, 2001
    Publication date: June 6, 2002
    Inventors: Benjamin Eithan Reubinoff, Martin Frederick Pera, Tamir Ben-Hur