Patents by Inventor Bernard Malfroy-Camine

Bernard Malfroy-Camine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180355023
    Abstract: The instant invention comprises Trappin-2 expressed through stable integration into the genome of a lactic acid bacteria useful in the treatment of diseases characterized by damaging elastolytic activity, or bacterial infection.
    Type: Application
    Filed: September 21, 2016
    Publication date: December 13, 2018
    Applicant: Vithera Pharmaceuticals, Inc.
    Inventors: Bernard Malfroy-Camine, Laura Holberger, Johannes Fruehauf
  • Publication number: 20110136774
    Abstract: The present invention provides low molecular weight porphyrin compositions for inhibiting, preventing or delaying the binding of a ligand of a mitochondrial benzodiazepine receptor. The invention also provides pharmaceutical compositions comprising these porphyrin compositions and their use in the treatment of conditions involving the mitochondrial benzodiazepine receptor or interactions between the receptor and the mitochondrial permeability transition pore e.g., drug overdose or apoptosis including neural degeneration and radiation-induced apoptosis.
    Type: Application
    Filed: December 21, 2010
    Publication date: June 9, 2011
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Publication number: 20100267825
    Abstract: Methods and apparatus are disclosed for diagnosing and treating oxidative skin damage in a subject. The therapeutic method can comprise: (i) diagnosing a level of oxidative skin damage in a sample comprising stratum corneum of the subject; and (ii) recommending a therapeutic regime for treatment of oxidative skin damage in the subject, wherein said recommendation comprises a recommendation to administer a pharmaceutical formulation comprising an amount of one or more specific synthetic SOD/catalase mimetics sufficient to treat the level of oxidative skin damage of the subject as diagnosed. The diagnostic method can further include obtaining a sample from the stratum corneum of a subject; measuring the level of at least one oxidized substance in the sample; and comparing a detected level of the oxidized substance with a standard, whereby an elevated level of the oxidized substance is indicative of skin damage.
    Type: Application
    Filed: April 14, 2010
    Publication date: October 21, 2010
    Applicant: Eukarion, Inc.
    Inventor: Bernard Malfroy-Camine
  • Publication number: 20100120738
    Abstract: The present invention provides low molecular weight porphyrin compositions for inhibiting, preventing or delaying the binding of a ligand of a mitochondrial benzodiazepine receptor. The invention also provides pharmaceutical compositions comprising these porphyrin compositions and their use in the treatment of conditions involving the mitochondrial benzodiazepine receptor or interactions between the receptor and the mitochondrial permeability transition pore e.g., drug overdose or apoptosis including neural degeneration and radiation-induced apoptosis.
    Type: Application
    Filed: September 11, 2007
    Publication date: May 13, 2010
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Publication number: 20090311230
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Application
    Filed: December 11, 2008
    Publication date: December 17, 2009
    Inventors: BERNARD MALFROY-CAMINE, Susan Robin Doctrow
  • Patent number: 7582786
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: September 1, 2009
    Assignee: Eukarion Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Publication number: 20070123503
    Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.
    Type: Application
    Filed: September 15, 2006
    Publication date: May 31, 2007
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Patent number: 7122537
    Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: October 17, 2006
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Publication number: 20060149089
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Application
    Filed: February 23, 2006
    Publication date: July 6, 2006
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Publication number: 20050249796
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Application
    Filed: May 27, 2005
    Publication date: November 10, 2005
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Patent number: 6900198
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: May 31, 2005
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Publication number: 20040059107
    Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.
    Type: Application
    Filed: May 27, 2003
    Publication date: March 25, 2004
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Patent number: 6703019
    Abstract: The subject application discloses methods and compositions for the targeted detection and/or inhibition of an intracellular protein in a cell by contacting the cell with a cationized antibody which reacts specifically with the intracellular protein. An example of an intracellular protein which can be inhibited in this manner is the Tat protein which is encoded by the HIV-1 virus.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: March 9, 2004
    Inventor: Bernard Malfroy-Camine
  • Publication number: 20030216371
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Application
    Filed: May 30, 2003
    Publication date: November 20, 2003
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Patent number: 6589948
    Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: July 8, 2003
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Patent number: 6573257
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: June 3, 2003
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Publication number: 20020002157
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Application
    Filed: April 4, 2000
    Publication date: January 3, 2002
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Patent number: 6046188
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: April 4, 2000
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Patent number: 5834509
    Abstract: This invention provides salen-manganese complexes and pharmaceutically acceptable compositions thereof useful as antioxidants and free radical scavengers.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 10, 1998
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Patent number: 5827880
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: October 27, 1998
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow