Abstract: An intraluminal device for delivering laser light and pressure waves includes a flexible elongate member positionable within a body lumen. The member includes an outer sheath; a laser catheter attached within the sheath; a sealed lens assembly located at the sheath's distal end; and a fluid chamber within the sheath, distal of the laser catheter and proximal of the lens assembly. The outer sheath includes a sealed acoustic window radially outward from the fluid chamber. When the chamber is filled with a fluid, a laser beam emitted by the laser catheter causes the photoreactive fluid to generate a pressure wave. When the chamber is filled with the fluid, a second laser beam emitted by the laser catheter exits via the transparent fluid and the sealed lens assembly. The sealed acoustic window and sealed lens assembly prevent the fluid from entering the body lumen.

Abstract: The present invention relates to ventricular drain placement. In order to provide improved guidance in ventricular drain placement for emergency situations, a guiding device (10) for emergency ventricular drain placement is provided comprising an image data input (12), a data processor (14) and an output interface (16). The image data input provides optical sensor-based image data of a head of a subject. The data processor generates an optical shape of the head based on the image data and provides a plurality of datasets of heads with different head shapes, wherein each dataset comprises a spatially assigned trajectory for a ventricular drain placement for the respective head shape. The data processor maps the generated optical shape of the head with at least two of the head shapes of the plurality of datasets and determine a best matching head shape of the dataset and further selects the respective assigned trajectory.

Abstract: An orthopedic pin (100) for optically analyzing a bone region (110) includes an elongate shaft (101) and at least one optical fiber (105). The elongate shaft has a circular outer cross section with a first diameter (D1), a distal end (102) for insertion into bone, a proximal end (103), and an optical connector portion (104) disposed towards the proximal end (103). The at least one optical fiber (105) extends within the elongate shaft (101) between the optical connector portion (104), and the distal end (102) for transmitting optical radiation between the optical connector portion (104) and the bone region (110) when the distal end (102) is inserted into the bone region (110). The optical connector portion (104) comprises a reduced-diameter portion (106). The reduced-diameter portion (106) extends along at least a portion of the elongate shaft (101), and has an outer cross section comprising a width (Drd) perpendicularly with respect to the elongate shaft (101).

Abstract: The invention refers to a system (100) for affecting a subject and a method for operating the system comprising a medical device like a biopsy gun (130) set in a first state in which it is not able to affect the subject based on a trigger signal or in a second state in which it is able to affect the subject based on the trigger signal, wherein the state is set based on a provided location of the medical device, i.e., for instance, is set based on the distance of the medical device to a target region. The location of the medical device is provided by a location providing unit (140) comprising, for instance, an imaging unit like an ultrasound system (142). Thus, unintended, possible dangerous injuries of the patient are prevented and the safety of the patient during the interventional procedure is increased.

Abstract: A system SY for determining a tissue type TY of a tissue region TR is provided in which the distal ends OFDE1..n of at least three optical fibers define a plurality of intersecting optical paths IOP1..k within the tissue region TR. A tissue signal Q1..k indicative of a tissue type TY for the respective optical path IOP1..k is generated from said spectral measurement data SMD corresponding to each of the plurality of intersecting optical paths IOP1..k. Each tissue signal Q1..k is compared with a reference threshold QRT for the tissue type, and with an average of the tissue signals QMA. At least a portion of the tissue region is identified as the tissue type TY if i) every tissue signal Q1..k in the tissue region TR indicates that its corresponding tissue is not the tissue type TY in the comparison with the reference threshold QRT and ii) at least one of the tissue signals Q1..k in the tissue region TR lies between the average QMA of the tissue signals Q1..

Abstract: Perfusion angiography combined with photoplethysmography imaging for peripheral vascular disease assessment A device (13) and method for performing perfusion imaging receive image sequences that are acquired simultaneously by an X-ray imaging apparatus (2) and by a photoplethysmography imaging apparatus (3). When temporally aligned, changes in the perfusion states of a perfused organic tissue over time are extracted from the two image sequences and an image is generated for display on a display unit (5) which indicates the changes in the perfusion states at various locations of the perfused organ tissue, thereby capturing both deep organ tissue and superficial organ tissue perfusion properties. A diminution in an image signal strength in the photoplethysmography images caused by a passage of a bolus comprising a previously administered contrast agent (10) can be used to align the two concurrently acquired image sequences in time.

Abstract: The present invention relates to guidance during a medical intervention. In order to provide an improved navigation support with a facilitated setup, a system (10) for navigation support is provided. An image data input (12) receives a plurality of acquired 2D X-ray images of a subject's body from different angles. A set of markers, which are visible in X-ray images and which are detectable by a navigation system, is assigned to the subject. A marker detecting arrangement (16) is provided that detects a current spatial location of the markers assigned to the subject. A data processor (14) reconstructs a 3D volume of the subject based on the plurality of 2D X-ray images. At least a part of the markers is arranged outside the volume covered by the reconstructed 3D volume of the subject, while the markers are visible in the 2D X-ray images.

Abstract: A mechanism for generating and providing one or more quality measures of a mapping function (for mapping electrical responses of an electrode to a predicted position of that electrode within an anatomical cavity) to a user, such as a clinician. Each quality measure predicts or indicates a quality of a mapping function with respect to a particular part of an anatomical cavity, for instance, indicating a predicted accuracy of the mapping function for predicting a position of an electrode located within a particular portion of the anatomical cavity. A user-perceptible output is provided that indicates the quality measure for the user.

Abstract: The application relates to the problem of navigating a surgical instrument (at 301, 311) towards a region-of-interest (at 312) in endoscopic surgery when an image (300) provided by the endoscope is obscured at least partly by obscuring matter (at 303), wherein the obscuring matter is a leaking body fluid, debris or smoke caused by ablation. To address this problem, a computer-implemented method is proposed, wherein, upon detecting that the image from the endoscope is at least partly obscured, a second image is determined based on a sequence of historic images and based on the current position and orientation of the endoscope. Furthermore, a virtual image (310) is generated based on the determined second image.

Abstract: A mechanism for determining a shape of an interventional device. A mapping function is used to predict the position of an electrode, mounted on the interventional device, as the interventional device is moved within an anatomical cavity—to thereby form a sequence of predicted positions. The sequence of predicted positions is then processed to predict a shape of the interventional device.

Abstract: A mechanism for generating a mapping function for mapping measurements taken at an electrode within crossing electric fields to a position or positions within a multidimensional co-ordinate system. The values for coefficients of the mapping function are generated using a first machine-learning algorithm, which receives, as input, example measurements (or responses) of the electrode and provides, as output, values for the coefficients for the mapping function. There is proposed a method and processing system for carrying out this mechanism.

Abstract: The invention relates a system for implanting an implantable device in bone tissue, a processing unit for such system, a method of implanting an implantable device and a method of providing information for an implanting of an implantable device. In view of the finding that a fat content in cancellous bone is higher than a fat content in compact bone, the lipids fraction, which can be determined by optical means, e.g. spectroscopy, can be used to determine correct screw placement in healthy bone.

Abstract: The invention provides a system for investigating a tissue of a subject by way of diffuse reflectance spectroscopy, the tissue including a fluorescent agent adapted to absorb light in a first wavelength range and emit light in a second wavelength range, different to the first. The system includes a cannula having a distal end to be positioned adjacent the tissue and an internal cavity for providing a suction force to the tissue. The system further includes a light source adapted to generate light at the first wavelength range and a fiber optic element to be positioned adjacent the tissue. The fiber optic element is adapted to receive a light signal from the fluorescent agent, the light signal comprising light in the first and second wavelength ranges. The system further includes a processing system adapted to determine a concentration of the fluorescent agent in the tissue based on the light signal.

Abstract: The invention relates to a detection apparatus (30) for determining a state of tissue. The detection apparatus (30) comprises a fluorescence spectrum providing unit (2, 3) for providing a fluorescence spectrum of the tissue, a differentiation unit (4) for generating a derivative of the fluorescence spectrum, and a tissue state determination unit (5) for determining the state of the tissue from the derivative. This allows determining the state of the tissue, even if characteristics, which are related to the state of the tissue, are only hardly visible or not visible at all in the fluorescence spectrum. The reliability of determining the state of the tissue, for instance, whether the tissue is cancerous or not, can therefore be improved.

Abstract: The invention relates to a system (8) for assisting a user in placing a penetrating device in tissue like a pedicle screw (7) in a vertebra’s pedicle. The system generates a virtual view (20) from a penetrating device tip perspective within the tissue in the direction of a path (21) through a model of the tissue. The virtual view is generated based on tracking information indicating a pose of the penetrating device, the model and the path, wherein the virtual view is configured such that it indicates a direction in which the user should move the penetrating device while placing it in the tissue. For instance, it can show a virtual tunnel (801) which is arranged along the path. If a user like a surgeon is provided with such a virtual view, the user can position the penetrating device along the path with a significantly increased accuracy.

Abstract: A system is suggested comprising an optical sensing means and a processing unit. The optical sensing means may include an optical guide with a distal end, wherein the optical guide may be configured to be arranged in a device to be inserted into tissue in a region of interest. The processing unit may be configured to receive information of a region of interest including different tissue types as well as of a path through the tissues, to determine a sequence of tissue types along the path, to determine a tissue type at the distal end of the optical guide based on information received from the optical sensing means, to compare the determined tissue type with the tissue types on the path, to determine possible positions of the distal end of the optical guide on the path based on the comparison of tissue types, and to generate a signal indicative for the possible positions.

Abstract: The present invention relates to a device for determining information relating to a suspected occluding structure. It is described to provide (210) a spectral resolving unit with at least one broadband radiation. The at least one broadband radiation comprises a first broadband radiation acquired from a region of interest within a vascular structure. An occluding structure is suspected to be located within the region of interest and wherein the first broadband radiation is associated with the suspected occluding structure. At least one spectrally resolved data set is determined (220) on the basis of the at least one broadband radiation, wherein the at least one spectrally resolved data set comprises a first spectrally resolved data set determined on the basis of the first broadband radiation. A processing unit is provided (230) with the at least one spectrally resolved data set on the basis of the at least one broadband radiation.

Abstract: A tissue sensing device for use with an electrosurgical knife is proposed which comprises a proximal end portion, a distal end portion and a grip portion there between. The proximal end portion is configured for attachment to a housing of the electrosurgical knife. The distal end portion is configured for movably supporting a blade of the knife. A distal end of an optical fiber is arranged at the distal end portion of the device and a proximal end of the optical fiber is connectable to an optical console, so that optical measurements can be performed at the distal end portion.

Abstract: An orthopedic pin is for optically analyzing a bone region. An optical fiber arrangement extends within an elongate shaft from a distal end to a proximal end. There is a coupling at an intermediate position along the shaft, and the optical fiber arrangement comprises a first portion on one side of the coupling and a second portion on the other side of the coupling. The coupling allows relative rotation between portions of the shaft at opposite sides of the coupling, while maintaining optical coupling between the first and second portions of the optical fiber.

Abstract: The present invention relates to a device for determining information relating to a suspected occluding structure. It is described to provide (210) a spectral resolving unit with at least one broadband radiation. The at least one broadband radiation comprises a first broadband radiation acquired from a region of interest within a vascular structure. An occluding structure is suspected to be located within the region of interest and wherein the first broadband radiation is associated with the suspected occluding structure. At least one spectrally resolved data set is determined (220) on the basis of the at least one broadband radiation, wherein the at least one spectrally resolved data set comprises a first spectrally resolved data set determined on the basis of the first broadband radiation. A processing unit is provided (230) with the at least one spectrally resolved data set on the basis of the at least one broadband radiation.