Abstract: A method and system for motion estimation and compensation are disclosed. Initially, a set of one or more initial images is reconstructed using acquired imaging data. Further, one or more regions of interest are identified in this set of reconstructed initial images. At least a set of filters is applied to the identified regions of interest to generate a sequence of filtered images. Particularly, each of the filtered images in the generated sequence of filtered images includes data acquired near a different reference point. Subsequently, a motion path corresponding to each region of interest is determined based on one or more correspondences in the sequence of filtered images.

Abstract: Systems and method for reconstruction of x-ray images are provided. One method includes acquiring a plurality of image views using an x-ray imaging system, the plurality of image views defining a limited tomographic dataset. The method also includes performing three-dimensional (3D) image reconstruction using the plurality of image views in an iterative reconstruction, wherein the iterative reconstruction includes forming a linear combination based on a plurality of previous iteration results. The method further includes displaying an image based on the image reconstruction, wherein the image includes clinically relevant high-frequency detail information.

Abstract: A method is provided that receives existing input image data of an object where the input image includes one or more regions of interest. Reference image data of the object is acquired by an imaging system and the scanning coordinates corresponding to the reference image data are registered with the scanning coordinates of the input image. Subsequent image data of the object is acquired by the imaging system based on the one or more regions of interest.

Abstract: Systems and method for reconstruction of x-ray images are provided. One method includes acquiring a plurality of image views using an x-ray imaging system, the plurality of image views defining a limited tomographic dataset. The method also includes performing three-dimensional (3D) image reconstruction using the plurality of image views in an iterative reconstruction, wherein the iterative reconstruction includes forming a linear combination based on a plurality of previous iteration results. The method further includes displaying an image based on the image reconstruction, wherein the image includes clinically relevant high-frequency detail information.

Abstract: An imaging system includes a portable litter including a structural housing and a digital detector positioned in the structural housing to detect X-ray signals corresponding to a region of interest to be imaged. The imaging system further includes at least one X-ray source for generating the X-ray signals, the at least one X-ray source positioned above the portable litter on an open gantry arrangement and configured to generate X-rays from different focal spot locations.

Abstract: Dual modality detection devices and methods are provided for detecting nuclear material, the devices include a neutron detector including multiple neutron detection modules; and a gamma detector including multiple gamma detection modules, where the multiple neutron detection modules and the multiple gamma detection modules are integrated together in a single unit to detect simultaneously both gamma rays and neutrons.

Abstract: A technique is provided for three-dimensional imaging in a non-calibrated geometry. In one embodiment, the technique includes acquiring a plurality of projection images through an imaging volume; estimating an imaging geometry using at least one of fiducial markers or anatomical features represented in the projection images; and reconstructing a configurable volumetric representation of some or all of the imaging volume using the estimated imaging geometry, wherein the act of reconstructing accounts for one or more geometry dependent factors. In addition, a system is provided which includes a computer configured to estimate an imaging geometry using at least one of fiducial markers or anatomical features represented in a plurality of projection images acquired through an imaging volume and to reconstruct a configurable volumetric representation of some or all of the imaging volume using the estimated imaging geometry, wherein the act of reconstructing accounts for one or more geometry dependent factors.

Abstract: A technique is provided for performing diagnosis and/or analysis of a volumetric image generated via anatomy based reconstruction. The technique includes generating a three-dimensional image by reconstructing a plurality of residual projection images from which a contribution of one or more structures of interest has been removed. The technique also includes evaluating the three-dimensional image and/or the plurality of residual projection images to generate a diagnosis.

Abstract: A method and system for motion estimation and compensation are disclosed. Initially, a set of one or more initial images is reconstructed using acquired imaging data. Further, one or more regions of interest are identified in this set of reconstructed initial images. At least a set of filters is applied to the identified regions of interest to generate a sequence of filtered images. Particularly, each of the filtered images in the generated sequence of filtered images includes data acquired near a different reference point. Subsequently, a motion path corresponding to each region of interest is determined based on one or more correspondences in the sequence of filtered images.

Abstract: A multi-view imaging system and method is disclosed.

Abstract: A technique is provided for geometrical analysis and calibration of a volumetric imaging system. The technique includes computing a projection error between estimated locations of a set of markers of a phantom based on a estimated imaging geometry and observed locations of the respective markers for at least one projection image, decomposing the computed projection error into one or more error components corresponding to respective geometric parameters of the imaging geometry, and updating at least one parameter of the estimated imaging geometry based on the one or more error components.

Abstract: A method and system for presenting images of an object of interest is provided. The method includes producing one or more cine loops of images from at least one of multiple projection views or multiple reconstructed 3D images including a 3D volume obtained from one or more beamlines. The method also includes generating at least one combined image including a first component and a second component wherein the first component and the second component each include one of a baseline image or the one or more cine loops of images. The combined image is generated via at least one of superimposing the first component and the second component, displaying the first component adjacent to the second component, and toggling between the first component and the second component. The method also includes displaying the at least one combined image.

Abstract: In one embodiment, a method of tomographic image construction includes performing sparsification on initial projection data for an object with a processor to provide sparsified projection data of the object. The method also includes backprojecting the sparsified projection data with the processor to provide a three-dimensional image of the object, and performing sparsification on the three-dimensional image with the processor to provide a sparsified image.

Abstract: The invention is a directed to an apparatus for tomosynthesis imaging, wherein the apparatus comprises an x-ray source configured to irradiate an object with a beam of x-rays and a detector configured to detect the x-ray beam that passes through the object. The apparatus further comprises a computer programmed to perform a scan, wherein the scan comprises a translation of at least one of the x-ray source and the detector along a path, an acquisition of a tomosynthesis image dataset, and a reconstruction of one or more three-dimensional (3D) volumes adapted to one or more predetermined view directions, wherein at least one of the one or more predetermined view directions is aligned outside of a central view direction.

Abstract: A method for imaging a breast is provided. The method includes positioning a breast within a breast holder including a flexible membrane and creating at least a partial vacuum within the flexible membrane. A method of upgrading a mammography system and various configurations of breast holders are also provided.

Abstract: A technique is provided for comparative image analysis and/or change detection using computer assisted detection and/or diagnosis (CAD) algorithms. The technique includes registering two or more images, comparing the images with one another to generate a change map, and detecting anomalies in the images based on the change map.

Abstract: Some configurations of method for reconstructing a volumetric image of an object include obtaining a tomosynthesis projection dataset of an object. The method also includes utilizing the tomosynthesis projection dataset and additional information about the object to minimize a selected energy function or functions to satisfy a selected set of constraints. Alternatively, constraints are applied to a reconstructed volumetric image in order to obtain an updated volumetric image. A 3D volume representative of the imaged object is thereby obtained in which each voxel is reconstructed and a correspondence indicated to a single one of the component material classes.

Abstract: A tomosynthesis system for forming a three dimensional image of an object is provided. The system includes an X-ray source adapted to irradiate the object with a beam of X-rays from a plurality of positions in a sector, an X-ray detector positioned relative to the X-ray source to detect X-rays transmitted through the object and a processor which is adapted to generate a three dimensional image of the object based on X-rays detected by the detector. The detector is adapted to move relative to the object and/or the X-ray source is adapted to irradiate the object with the beam of X-rays such that the beam of X-rays follows in a non arc shaped path and/or a center of the beam of X-rays impinges substantially on the same location on the detector from different X-ray source positions in the sector.

Abstract: A tomosynthesis system for forming a three dimensional image of an object is provided. The system includes an X-ray source adapted to irradiate the object with a beam of X-rays from a plurality of positions in a sector, an X-ray detector positioned relative to the X-ray source to detect X-rays transmitted through the object and a processor which is adapted to generate a three dimensional image of the object based on X-rays detected by the detector. The detector is adapted to move relative to the object and/or the X-ray source is adapted to irradiate the object with the beam of X-rays such that the beam of X-rays follows in a non arc shaped path and/or a center of the beam of X-rays impinges substantially on the same location on the detector from different X-ray source positions in the sector.

Abstract: A technique is provided for generating quantitative projection images from projection images. The pixels of the quantitative projection images correspond to quantitative composition estimates of two or more materials. The quantitative projection images are reconstructed to generate a quantitative volume in which each voxel value corresponds quantitatively to the two or more materials or a mixture of the two or more materials.