Patents by Inventor Bernhard Gleich

Bernhard Gleich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200250829
    Abstract: The invention provides for a medical instrument (100, 300, 400) comprising: a memory (110) for storing machine executable instructions (112) and a processor (106) for controlling the medical instrument.
    Type: Application
    Filed: August 30, 2018
    Publication date: August 6, 2020
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: BERNHARD GLEICH, JORN BORGERT, JOCHEN KEUPP
  • Patent number: 10267873
    Abstract: An apparatus for operation in a magnetic particle imaging mode for influencing and/or detecting magnetic particles in a field of view, and for operation in a magnetic resonance imaging mode, includes a selector having a selection field signal generator and selection field coils, a driver having a drive field signal generator and drive field coils for changing the position in space of the two sub-zones in the field of view by a magnetic drive field so that the magnetization of magnetic particles changes locally, and a focuser having a focus field signal generator and a focus field coil unit for changing the position in space of the field of view by a magnetic focus field.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: April 23, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Bernhard Gleich, Juergen Erwin Rahmer
  • Patent number: 10168408
    Abstract: The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), in particular an MPI apparatus. The apparatus comprises selection field elements (116) for generating a magnetic selection field (50), drive field coils (124; 125, 126, 127) for changing the position in space of the two sub-zones (52, 54) by means of a magnetic drive field, focus field elements (116) for changing the position in space of the field of view (28) by means of a magnetic focus field, and receiving elements (148) for acquiring detection signals. A static system function of the apparatus is obtained in the absence of a magnetic focus field, from which an extended system function is generated by shifting a time-domain representation of said static system function proportional to the changes of the position of the field of view caused by appliance of the magnetic focus field.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: January 1, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jurgen Erwin Rahmer, Bernhard Gleich
  • Publication number: 20180303375
    Abstract: The invention relates to an examination apparatus (100), a method and a computer program for tracking permanently magnetic beads (107) that are transported by a fluid flowing through a channel (106) of an object (105). The examination apparatus (100) comprises at least three magnetic field sensors (101, 102, 103) and an evaluation unit (104). With the magnetic field sensors, the magnetic field caused by the permanently magnetic beads (107) is detected. Due to shear forces acting in the fluid, the permanently magnetic beads (107) are rotating and the magnetic field caused by the beads (107) is temporally varying. This temporal variation of the magnetic field is used by the evaluation unit (104) for discriminating sub-signals related to single beads (107) from the overall signal generated by the magnetic field sensors. Furthermore, the evaluation unit determines positioning information of individual beads on the basis of the discriminated sub-signals.
    Type: Application
    Filed: October 17, 2016
    Publication date: October 25, 2018
    Inventor: BERNHARD GLEICH
  • Patent number: 9918655
    Abstract: The present invention relates to an apparatus (100) for measuring the internal pressure of an examination object, in particular the internal pressure of a blood vessel, by use of a magnetic pressure measurement device (60, 70) introduced into the examination object, which apparatus comprises: —magnetic field generating means comprising magnetic field signal generator units (130) and magnetic field coils (136a, 136b, 136c) for generating a magnetic field for influencing the magnetization of the magnetic pressure measurement device (60, 70), receiving means comprising at least one signal receiving unit (140) and at least one receiving coil (148) for acquiring detection signals, which detection signals depend on the changes in magnetization of the magnetic pressure measurement device (60, 70) caused by the magnetic field and on the changes of the physical properties of the magnetic pressure measurement device caused by the internal pressure of the examination object, and evaluation means (153) for evaluating the
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: March 20, 2018
    Assignee: Koninklijke Philip N.V.
    Inventors: Bernhard Gleich, Ingo Schmale
  • Patent number: 9903837
    Abstract: An apparatus (100) detects magnetic particles in a field of view (28). The apparatus includes selection and focus magnetic field coil pairs (12, 14), drive pairs (16), and detection coils (148). A computer is configured to receive background signals with the detection coils, controls current supplied to the drive coil pair to shift the field of view in space, and reconstruct detection signals from the detection coils into an image of the field of view (28). The computer selects one or more frequency components of the detection signals and/or weighted by use of a frequency component specific signal quality factor obtained from the background signal measurements. Only the selected and/or weighted frequency components are used for reconstruction of the image.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: February 27, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jurgen Erwin Rahmer, Bernhard Gleich, Jurgen Weizenecker
  • Patent number: 9820672
    Abstract: A method for colon screening and collecting data by using Magnetic Particle Imaging wherein an imaging magnetic field is generated with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated. The spatial location of both sub-areas in the area of examination is modified so that the magnetization of said particles changes locally. Signals are acquired and are evaluated to obtain information about the spatial distribution of the signals in the area of examination. The method may be carried out during an entire peristaltic cycle in a colon portion or segment.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: November 21, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Jörn Borgert, Ingo Schmale, Jürgen Erwin Rahmer, Bernhard Gleich, Michael Harald Kuhn
  • Patent number: 9808173
    Abstract: Method for the spatially resolved determination of physical, chemical and/or biological properties or state variables and/or the change therein in an examination area of an examination object by determining the change in the spatial distribution and/or the mobility, particularly the mobility in rotation, of magnetic particles in this examination area or in parts thereof as a function of the effect of physical, chemical and/or biological influencing variables on at least a part-area and/or in the physical, chemical and/or biological conditions in at least a part-area of the examination area, by means of the following steps: a) introducing covered and/or coated magnetic particles with at least one solid, viscous and/or liquid shell or coating into at least part of the examination area and/or introducing magnetic particles into at least part of the examination area and/or covering and/or coating at least some of these particles in the examination area, b) generating a magnetic field with a spatial profile of the
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: November 7, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Bernhard Gleich
  • Patent number: 9770304
    Abstract: A multimodal fiducial marker for registration of multimodal data, including a first portion comprising magnetic material visible in magnetic particle imaging (MPI) data obtained by a magnetic particle imaging method and a second portion comprising a second material visible in image data obtained by another imaging method, which image data is registrable with the MPI data and a corresponding marker arrangement.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: September 26, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jürgen Erwin Rahmer, Bernhard Gleich, Jörn Borgert, Michael Harald Kuhn
  • Publication number: 20170225003
    Abstract: The present invention relates to an apparatus and a method for targeted drug delivery by use of a drug substance comprising a drug and magnetic particles.
    Type: Application
    Filed: July 28, 2015
    Publication date: August 10, 2017
    Inventor: BERNHARD GLEICH
  • Patent number: 9689932
    Abstract: The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view (28), in particular for examination of human patients.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: June 27, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Claas Bontus, Ingo Schmale, Bernhard Gleich
  • Publication number: 20170106421
    Abstract: The present invention relates to manufacturing of litz wire. In order to provide thinner litz wires, a system (100) for manufacturing litz wire is provided, the system comprising a provision unit (102) and a conversion unit (104). The provision unit is configured to provide a strand (106) with a plurality (108) of thin conductive wires (110) embedded in a matrix (112), which matrix is having first characteristics comprising metallic connection of the conductive wires and the matrix, and comprising electrical conductivity for electrically connecting of the conductive wires and the matrix. The conversion unit is configured to convert at least a part of the matrix into material (114) having second characteristics comprising electrical insulation for providing at least a part of the plurality of thin conductive wires with an electrical insulation.
    Type: Application
    Filed: May 18, 2015
    Publication date: April 20, 2017
    Applicant: Koninklijke Philips N.V.
    Inventor: BERNHARD GLEICH
  • Patent number: 9603544
    Abstract: The present invention relates to a method of determining physical, chemical and/or biological state variables, particularly substance concentrations, temperature, pH and/or physical fields, and/or the change in these state variables in an examination area of an examination object by determining the change in the spatial distribution of magnetic particles in this examination area as a function of the effect of influencing variables on at least a partarea and/or in the conditions in at least a part-area of the examination area, by means of the following steps: a) introducing magnetic particles into at least part of the examination area in a first state in which in the examination area or in parts thereof at least some of the magnetic particles that are to be examined are agglomerated and/or coupled to one another in pairs or more, or introducing magnetic particles into at least part of the examination area in a second state in which the particles are deagglomerated and/or decoupled and can be agglomerated and/o
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: March 28, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Bernhard Gleich
  • Patent number: 9480413
    Abstract: A system for determining the spatial distribution of magnetic particles in an examination area. Magnetic field generator generates a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By an arrangement to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by a detector. At least one of the magnetic field generator, the arrangement and the detector are arranged at least partially on a medical instrument.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: November 1, 2016
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Bernhard Gleich, Juergen Weizenecker, Nielsen Tim
  • Patent number: 9439579
    Abstract: Method for influencing and/or detecting magnetic particles in a field of view. Selection coils/magnets generate a magnetic selection field and drive coils generate a magnetic drive field for moving a field-free point along a predetermined trajectory through the field of view, changing the magnetization of the magnetic material locally. The drive field comprises a time-dependent oscillating drive field current per drive field coil having one or more individual oscillating frequencies and one or more individual current amplitudes and being generated by a corresponding drive field voltage generated by a superposition of a number of drive field voltage components including a drive field voltage component per drive field coil, wherein a drive field voltage component corresponding to a drive field coil comprises one or more sub-components, each having an individual voltage amplitude and having the same individual oscillating frequency as the respective drive field current of said particular drive field coil.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: September 13, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Claas Bontus, Bernhard Gleich
  • Publication number: 20160216355
    Abstract: The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), in particular an MPI apparatus. The apparatus comprises selection field elements (116) for generating a magnetic selection field (50), drive field coils (124; 125, 126, 127) for changing the position in space of the two sub-zones (52, 54) by means of a magnetic drive field, focus field elements (116) for changing the position in space of the field of view (28) by means of a magnetic focus field, and receiving elements (148) for acquiring detection signals. A static system function of the apparatus is obtained in the absence of a magnetic focus field, from which an extended system function is generated by shifting a time-domain representation of said static system function proportional to the changes of the position of the field of view caused by appliance of the magnetic focus field.
    Type: Application
    Filed: September 11, 2013
    Publication date: July 28, 2016
    Inventors: JURGEN ERWIN RAHMER, BERNHARD GLEICH
  • Publication number: 20160184601
    Abstract: A magnetic stimulator for stimulation of a tissue by a magnetic field, having a pulse generator device which comprises a pulse capacitor which can be charged by a charging circuit in order to generate a pulse sequence consisting of pulses and having an adjustable repeat rate; and having a programmable control device which adjusts the pulse generator device to generate a complex pulse sequence, which comprises individually configurable pulses, wherein the generated complex pulse sequence is applied to a stimulation coil in order to generate the magnetic field.
    Type: Application
    Filed: June 20, 2014
    Publication date: June 30, 2016
    Inventors: Bernhard Gleich, Nikolai Jung, Volker Mall, Norbert Gattinger
  • Patent number: 9370315
    Abstract: The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view (28). The apparatus comprises selection means for generating a magnetic selection field (50) and drive and receiving means comprising one or more combined drive field and selection coils (441) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) and for acquiring detection signals. A balanced bridge unit (160) comprising inductive or capacitive coupling elements (411, 421) is provided between the drive field signal generator unit (122) and the signal receiving unit (140) as a light-weight, inexpensive and easily implementable solution for reducing the harmonic background.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: June 21, 2016
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ingo Schmale, Bernhard Gleich
  • Patent number: 9364165
    Abstract: The present invention relates to an apparatus for moving a target element which comprises a magnetic material and an active agent, through an object, placing the target element at a predetermined position within the object and activating the active agent.
    Type: Grant
    Filed: September 6, 2010
    Date of Patent: June 14, 2016
    Assignee: Koninklijke Philips N.V.
    Inventor: Bernhard Gleich
  • Patent number: 9357943
    Abstract: An arrangement (10) and a method for imaging an object including a vessel (400), using magnetic particle imaging is provided. An image of the vessel (400) is reconstructed based on a known concentration of the magnetic particles (100) within the vessel (400) and on vessel tree data about the progression of said vessel (400). The reconstruction comprises defining cylinder elements (440) around an approximated image and stepwise and separately adapting the radii of the cylinder elements by integrating over the signal intensity of the cylinder elements, wherein the radii are adapted such that the integrated signal intensity over the cylinder elements equals the intensity expected from the known concentration of the magnetic particles in the vessel.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: June 7, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Bernhard Gleich, Juergen Weizenecker