Patents by Inventor Bernhard Kutscher

Bernhard Kutscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDIBULIN THERAPY
    Publication number: 20140193519
    Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 10, 2014
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: Barbara P. Wallner, Brian Eric Schwartz, Philip B. Komarnitsky, Gerald Bacher, Bernhard Kutscher, Gerhard Raab
  • Methods of treatment using novel LHRH antagonists having improved solubility properties
    Patent number: 7732412
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. The invention also relates methods for treating a hormone-dependent tumor or a non-malignant indication that is treatable by LH-RH suppression, the method comprising administering to a patient in need of the treatment a therapeutically effective amount of a compound of the invention. Hormone-dependent cancers that can be treated with the methods of the invention include prostate cancer, breast cancer, ovarian cancer, endometrial cancer, and pancreatic cancer. Non-malignant indications which can be treated by the methods of the invention include benign prostate hyperplasia (BPH), endometriosis, acne, polycystic ovarian disease, dysmenorrhea, precocious puberty, and uterine fibroids and other leiomyomas.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: June 8, 2010
    Assignee: Zentaris GmbH
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • Indibulin therapy
    Publication number: 20080241274
    Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.
    Type: Application
    Filed: November 27, 2007
    Publication date: October 2, 2008
    Applicant: ZIOPHARM Oncology, Inc.
    Inventors: Barbara P. Wallner, Brian Eric Schwartz, Philip B. Komarnitsky, Gerald Bacher, Bernhard Kutscher, Gerhard Raab
  • METHODS OF TREATMENT USING NOVEL LHRH ANTAGONISTS HAVING IMPROVED SOLUBILITY PROPERTIES
    Publication number: 20060281685
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. The invention also relates methods for treating a hormone-dependent tumor or a non-malignant indication that is treatable by LH-RH suppression, the method comprising administering to a patient in need of the treatment a therapeutically effective amount of a compound of the invention. Hormone-dependent cancers that can be treated with the methods of the invention include prostate cancer, breast cancer, ovarian cancer, endometrial cancer, and pancreatic cancer. Non-malignant indications which can be treated by the methods of the invention include benign prostate hyperplasia (BPH), endometriosis, acne, polycystic ovarian disease, dysmenorrhea, precocious puberty, and uterine fibroids and other leiomyomas.
    Type: Application
    Filed: July 24, 2006
    Publication date: December 14, 2006
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • LHRH antagonists having improved solubility properties
    Patent number: 7148195
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be used for the treatment of hormone-dependent tumors and hormone-influenced non-malignant disorders.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: December 12, 2006
    Assignee: Zentaris GmbH
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 7056912
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: June 6, 2006
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 7026310
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 11, 2006
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Publication number: 20050245523
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: June 14, 2005
    Publication date: November 3, 2005
    Inventors: Peter Emig, Eckhard Gunther, Jurgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6936615
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: August 30, 2005
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Novel heteroaryl derivatives and their use as medicaments
    Publication number: 20050176744
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: April 14, 2005
    Publication date: August 11, 2005
    Inventors: Peter Emig, Eckhard Gunther, Jurgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
    Patent number: 6919344
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 19, 2005
    Assignee: ASTA MEDICA, Aktiengesellschaft
    Inventors: Guillaume Lebaut, Cécilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Methods of modulating serine/threonine protein kinase function with quinazoline-based compounds
    Patent number: 6911446
    Abstract: The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with quinazoline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to quinazoline compounds and pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: June 28, 2005
    Assignee: Sugen, Inc.
    Inventors: Peng C. Tang, Gerald McMahon, Heinz Weinberger, Bernhard Kutscher, Harald App
  • Disease treatment with novel phospholipid derivatives
    Patent number: 6903080
    Abstract: A method of treating protozoal and fungal diseases is described, in which an effective amount of a compound of formula I is administered to a host having a protozoal or fungal disease.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: June 7, 2005
    Assignee: Zentaris GmbH
    Inventors: Gerhard Nossner, Bernhard Kutscher, Jurgen Engel, Wolfgang Schumacher, Margrit Stekar, Peter Hilgard, Jurij Stekar
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6890926
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: May 10, 2005
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds
    Patent number: 6855723
    Abstract: The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with azabenzimidazole-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to azabenzimidazole compounds and pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: February 15, 2005
    Assignee: Zentaris GmbH
    Inventors: Gerald McMahon, Heinz Weinberger, Bernhard Kutscher, Harald App
  • Novel LHRH antagonists having improved solubility properties
    Publication number: 20040266695
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be used for the treatment of hormone-dependent tumours and hormone-influenced non-malignant disorders.
    Type: Application
    Filed: September 29, 2003
    Publication date: December 30, 2004
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • Novel heteroaryl derivatives and their use as medicaments
    Publication number: 20040132747
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 8, 2004
    Inventors: Peter Emig, Eckhard Gunther, Jurgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Novel heteroaryl derivatives and their use as medicaments
    Publication number: 20040097530
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: November 14, 2003
    Publication date: May 20, 2004
    Inventors: Peter Emig, Eckhard Gunther, Jurgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds
    Patent number: 6727252
    Abstract: The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with 5-azaquinoxaline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to 5-azaquinoxaline compounds and pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: April 27, 2004
    Assignee: Zentaris AG
    Inventors: Gerald McMahon, Heinz Weinberger, Bernhard Kutscher, Harald App
  • N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
    Publication number: 20030207892
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.
    Type: Application
    Filed: April 1, 2003
    Publication date: November 6, 2003
    Inventors: Guillaume Lebaut, Cecilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune