Abstract: A process line (300) for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer (304) for freeze drying the particles, wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation, and the spray chamber (302) is adapted for separation of the liquid droplets from any cooling circuit.

Abstract: The invention concerns a spray nozzle for a fluidized bed device, said nozzle comprising a central liquid outlet (15) for a liquid coating agent and an annular air outlet (17) for conveying spraying air coaxially. An enclosing body (1) having a central recess (4) is maintained in a wall of the box of the fluidized bed device. Said enclosing body (1) is connected to a spraying air source through an air duct (6) and an axially mobile nozzle head (14) is centrally mounted inside said enclosing body (1). Said nozzle head (14) is connected to a liquid coating agent source through a liquid duct (10), said liquid duct (10) having a flexible tubular section (12) and being centrally guided inside the air duct (6).

Abstract: A process for measuring, monitoring and/or controlling directed product movements of fluidized products in process systems (1) selected from fluidized bed and spouted bed systems during a spraying process for coating and/or granulation, which includes, with the aid of one or more microwave sensor devices (8), injecting microwave radiation without contact into one or more product streams, receiving the microwave radiation reflected by the particles of the particular product stream and, on the basis of the microwave radiation received, forming and transmitting a measurement signal for the characterization of the product stream, the corresponding use of microwave sensor devices (8) and correspondingly equipped apparatus (1).

Abstract: The invention concerns a spray nozzle for a fluidized bed device, said nozzle comprising a central liquid outlet (15) for a liquid coating agent and an annular air outlet (17) for conveying spraying air coaxially. An enclosing body (1) having a central recess (4) is maintained in a wall of the box of the fluidized bed device. Said enclosing body (1) is connected to a spraying air source through an air duct (6) and an axially mobile nozzle head (14) is centrally mounted inside said enclosing body (1). Said nozzle head (14) is connected to a liquid coating agent source through a liquid duct (10), said liquid duct (10) having a flexible tubular section (12) and being centrally guided inside the air duct (6).

Abstract: The invention relates to a flowable fibrin adhesive granulate containing thrombin, Factor XIII, fibrinogen, and a calcium salt in the form of granules with a particle size of more than 50 ?m to 1000 ?m. Said granulate is useful for the healing of wounds in surgery, tissue therapy and/or as supporting material for biological factors. The invention also relates to an effervescent granulate and an effervescent powder for producing a foam that is suitable for hemostasis. The invention further relates to preparations to arrest bleeding containing a non-woven fabric for wounds consisting of a biodegradable supporting material that is coated with a fibrin glue granulate mixture or mixed granulate.

Abstract: A process for measuring, monitoring and/or controlling directed product movements of fluidized products in process systems (1) selected from fluidized bed and spouted bed systems during a spraying process for coating and/or granulation, which includes, with the aid of one or more microwave sensor devices (8), injecting microwave radiation without contact into one or more product streams, receiving the microwave radiation reflected by the particles of the particular product stream and, on the basis of the microwave radiation received, forming and transmitting a measurement signal for the characterization of the product stream, the corresponding use of microwave sensor devices (8) and correspondingly equipped apparatus (1).

Abstract: The invention relates to a flowable fibrin adhesive granulate containing thrombin, Factor XIII, fibrinogen, and a calcium salt in the form of granules with a particle size of more than 50 ?m to 1000 ?m. Said granulate is useful for the healing of wounds in surgery, tissue therapy and/or as supporting material for biological factors. The invention also relates to an effervescent granulate and an effervescent powder for producing a foam that is suitable for hemostasis. The invention further relates to preparations to arrest bleeding containing a non-woven fabric for wounds consisting of a biodegradable supporting material that is coated with a fibrin glue granulate mixture or mixed granulate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A central discharge assembly is provided at the lower end of the product containers for emptying particles from the machine.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. A nozzle ramp is provided around the nozzle. The nozzle ramp is generally cusp shaped and includes nozzle-ramp surface. The nozzle ramp is centrally positioned around the nozzle and is directed upwardly towards the partition so that the nozzle-ramp surface directs particles moving generally horizontally across the orifice plate from the down bed upwardly into the partition and the up bed. The nozzle ramp may further include air passages for passing fluidized air upwardly to the nozzle-ramp surface.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. The fluidized apparatus further includes a central first plenum located below the orifice plate and being aligned with the up-bed and the partition, the first plenum being sized and shaped to direct gas upwardly through the orifice plate and into the up-bed; and a second plenum located below the orifice plate positioned around the first plenum for directing gas upwardly through the orifice plate and into contact with particles located on the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.

Abstract: In the method for producing a particulate material (58) from an at least partially liquid material (35) containing a solvent and/or dispersant, this material (35) is atomized in a process chamber (21) into droplets which are frozen to particles (131) by contact with a freezing fluid. The particles (131) are then dried by freeze-drying in the or in another process chamber (22) having a filter (18) at the top. For the freeze-drying, cooled process gas is passed upward from below through the process chamber (22) and through the filter (18) in such a way that at least a substantial part of the particles (131) rest against the filter (18) at least for a substantial part of the freeze-drying taking place in the process chamber (22). This makes it possible to dry a batch of particles (131) in a short time.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: In the method for producing a particulate material (58) from an at least partially liquid material (35) containing a solvent and/or dispersant, this material (35) is atomized in a process chamber (21) into droplets which are frozen to particles (131) by contact with a freezing fluid. The particles (131) are then dried by freeze-drying in the or in another process chamber (22) having a filter (18) at the top. For the freeze-drying, cooled process gas is passed upward from below through the process chamber (22) and through the filter (18) in such a way that at least a substantial part of the particles (131) rest against the filter (18) at least for a substantial part of the freeze-drying taking place in the process chamber (22). This makes it possible to dry a batch of particles (131) in a short time.

Abstract: A method and a device function for monitoring and/or controlling and regulating a granulation, agglomeration, instantization, coating and drying process in a fluidized layer or a moving bulk by determining the product moisture. At least during one process segment the total product moisture is measured substantially continuously over a period of seconds, in a contact-free manner using electromagnetic radiation in the high frequency or microwave range, by evaluation of the attenuation of the radiation as a measure of this total product moisture. Taking into account the product temperature, the measurement result is used to hold the total product moisture in a pre-determined range via a control circuit by changing the spray rate and/or the gas temperature and/or the volume flow.

Abstract: A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.

Abstract: The apparatus has a container, which encloses a crude gas space, and at least one filter projecting into the crude gas space and having a filter axis and a shape-stable casing. This has a support member with two wire fabrics and a filtration member which forms its outer surface and has a wire fabric. The wire fabrics of the support member and of the filtration member are rotationally symmetrical with the filter axis, are adjacent to one another and are sintered with one another at the points of contact. When process gas is passed from the crude gas space through a filter, the process gas deposits dust present in it onto the outer surface of the casing. The or each filter is stable, durable and resistant to high or low temperatures and can be readily cleaned inside the container with a cleaning gas or a cleaning liquid.