Abstract: A capsule shell contains 40 to 99% by weight of a core-shell polymer and 1 to 60% by weight of a cellulose. The core-shell polymer contains 50 to 90% by weight of a core, containing polymerized units of 65 to 75% by weight of ethyl acrylate and 25 to 35% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 45 to 55% by weight of ethyl acrylate and 45 to 55% by weight of methacrylic acid.

Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Abstract: A capsule shell contains 40 to 99% by weight of a core-shell polymer and 1 to 60% by weight of a cellulose. The core-shell polymer contains 50 to 90% by weight of a core, containing polymerized units of 65 to 75% by weight of ethyl acrylate and 25 to 35% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 45 to 55% by weight of ethyl acrylate and 45 to 55% by weight of methacrylic acid.

Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Abstract: A particulate cellulose derivative is obtained in a process of grinding and drying a moist cellulose derivative which comprises the steps of A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative, B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill; C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill; and D) subjecting the cellulose derivative to partial depolymerization after having contacted the cellulose derivative with a drying gas in step C). The obtained particulate cellulose derivative has a high untapped bulk density, a good flowability and a low color intensity.

Abstract: A mixture of a cellulose derivative and a liquid diluent is prepared which comprises at least 5 weight percent of the cellulose derivative, based on the total weight of the cellulose derivative and the liquid diluent. The mixing operating causes air to be entrapped in the mixture. The time for at least partially removing entrapped air is reduced by providing a cellulose derivative having a specific surface area of less than 0.20 m2/g measured by BET method for preparing the mixture.

Abstract: A mixture of a cellulose derivative and a liquid diluent is prepared which comprises at least 5 weight percent of the cellulose derivative, based on the total weight of the cellulose derivative and the liquid diluent. The mixing operating causes air to be entrapped in the mixture. The time for at least partially removing entrapped air is reduced by providing a cellulose derivative having a specific surface area of less than 0.20 m2/g measured by BET method for preparing the mixture.

Abstract: A particulate cellulose derivative is obtained in a process of grinding and drying a moist cellulose derivative which comprises the steps of A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative, B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill; C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill; and D) subjecting the cellulose derivative to partial depolymerization after having contacted the cellulose derivative with a drying gas in step C). The obtained particulate cellulose derivative has a high untapped bulk density, a good flowability and a low color intensity.

Abstract: A particulate cellulose derivative is obtained in a process of grinding and drying a moist cellulose derivative which comprises the steps of A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative; B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill; C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill; and D) subjecting the cellulose derivative to partial depolymerization after having contacted the cellulose derivative with a drying gas in step C). The obtained particulate cellulose derivative has a high untapped bulk density, a good flowability and a low color intensity.

Abstract: A particulate cellulose derivative is obtained in a process of grinding and drying a moist cellulose derivative which comprises the steps of A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative; B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill; C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill; and D) subjecting the cellulose derivative to partial depolymerization after having contacted the cellulose derivative with a drying gas in step C). The obtained particulate cellulose derivative has a high untapped bulk density, a good flowability and a low color intensity.

Abstract: A film-forming composition comprising (a) a cellulose derivative such as HPMC and (b) a urea additive selected from urea, urea derivatives and mixtures thereof; the use of the film-forming composition as a shell material for hard capsules; and films and hard capsules prepared from the film-forming composition.

Abstract: The present invention relates to a process for the production of alkali cellulose for the production of alkali cellulose and, optionally, cellulose ethers from cellulose in the presence of alkali and, if applicable, with alkylating and/or hydroxyalkylating agent(s) comprising the reaction of a cellulose with an alkali metal hydroxide, wherein the alkali metal hydroxide is mixed with cellulose in a mixing apparatus, the mixing apparatus (1) having an upper region (20, 102a, 202a) with a first cross-section and a lower region (21, 102b, 202b) with a second cross-section, the second cross-section being the same as or smaller than the first cross-section and comprising at least one non-horizontally oriented mixing device (23, 27, 121, 221, 224).

Abstract: The present invention relates to a process for the production of alkali cellulose for the production of alkali cellulose and, optionally, cellulose ethers from cellulose in the presence of alkali and, if applicable, with alkylating and/or hydroxyalkylating agent(s) comprising the reaction of a cellulose with an alkali metal hydroxide, wherein the alkali metal hydroxide is mixed with cellulose in a mixing apparatus, the mixing apparatus (1) having an upper region (20, 102a, 202a) with a first cross-section and a lower region (21, 102b, 202b) with a second cross-section, the second cross-section being the same as or smaller than the first cross-section and comprising at least one non-horizontally oriented mixing device (23, 27, 121, 221, 224).

Abstract: An improved process for preparing carbamic ester derivatives of the general formula (1) by reaction with carbon monoxide and water in the presence of a palladium catalyst is provided.

Abstract: A novel one-stage process for preparing 10?-[4?-(S,S-dioxothiomorpholin-1?-yl)]-10-deoxo-10-dihydroartemisinin (1a) by reacting a compound of the formula (1b) in which X is a halogen atom with thiomorpholine dioxide at a temperature in the range of ?30° C. to +20° C. is provided.

Abstract: A novel one-stage process for preparing 10?-[4?-(S,S-dioxothiomorpholin-1?-yl)]-10-deoxo-10-dihydroartemisinin (1a) by reacting a compound of the formula (1b) in which X is a halogen atom with thiomorpholine dioxide at a temperature in the range of ?30° C. to +20° C. is provided.