Patents by Inventor Bettina Moeckel
Bettina Moeckel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050233373Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metH gene is present in enhanced form, and use of the polynucleotide sequences as hybridization probes.Type: ApplicationFiled: June 20, 2005Publication date: October 20, 2005Applicant: DEGUSSA AGInventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
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Patent number: 6949374Abstract: The invention relates to a genetically modified coryneform bacterium, the fadD15 gene of which is amplified, and an isolated polynucleotide which codes for acyl-CoA synthase from coryneform bacteria, and also a method for the fermentative preparation of L-amino acids with amplification of the fadD15 gene in the bacteria and the use of the polynucleotide as a primer or hybridization probe.Type: GrantFiled: May 16, 2001Date of Patent: September 27, 2005Assignee: Degussa AGInventors: Madhavan Nampoothiri K., Bettina Möckel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm
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Patent number: 6942996Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID. No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and p1 d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metE gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.Type: GrantFiled: August 2, 2001Date of Patent: September 13, 2005Assignee: Degussa AGInventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
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Patent number: 6939694Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the citB gene, and a host-vector system having a coryneform host bacterium in which the citB gene is present in attenuated form and a vector which carries at least the citB gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.Type: GrantFiled: August 31, 2001Date of Patent: September 6, 2005Inventors: Bettina Möckel, Thomas Hermann, Mike Farwick, Walter Pfefferle, Achim Marx
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Patent number: 6939695Abstract: An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.Type: GrantFiled: February 15, 2002Date of Patent: September 6, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Brigitte Bathe, Stefan Hans, Caroline Kreutzer, Thomas Hermann, Walter Pfefferle, Michael Binder
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Patent number: 6913908Abstract: The present invention relates lo an isolated polynucleotide from Corynebacterium glutamicum comprising a polynucleotide sequence chosen from the group c insisting of (a) a polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO: 2; (b) a polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide which is complementary to the polynucleotides of(a) or (b), and (d) a polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the sigE gene is present in enhanced form, and the use of polynucleotides which comprise the sequence according to the invention as hybridization probes.Type: GrantFiled: August 24, 2001Date of Patent: July 5, 2005Assignee: Degussa AGInventors: Bettina Möckel, Thoams Hermann, Mike Farwick, Michael Binder, Walter Pfefferle
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Patent number: 6913910Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising: a) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No.2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive bases of the polynucleotide sequence of a), b) or c), and processes for the fermentative production of L-amino acids by enhancement of the glk-gene coding for the enzyme glucokinase.Type: GrantFiled: July 18, 2002Date of Patent: July 5, 2005Assignee: Degussa AGInventors: Bettina Möckel, Walter Pfefferle
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Publication number: 20050130264Abstract: The present invention relates to polynucleotides corresponding to the rpoB gene and which encode the ?-subunit of RNA polymerase B, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having activity of the ?-subunit of RNA polymerase B.Type: ApplicationFiled: January 15, 2004Publication date: June 16, 2005Applicant: DEGUSSA AGInventors: Bettina Moeckel, Brigitte Bathe, Thomas Hermann, Walter Pfefferle, Michael Binder
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Patent number: 6902916Abstract: The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR1 transcriptional regulator activity.Type: GrantFiled: July 13, 2001Date of Patent: June 7, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
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Patent number: 6897055Abstract: The invention relates to polynucleotides that contain polynucleotide sequences coding for the genes sucC and sucD, selected from the group a) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 3, c) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No. 2, d) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No.Type: GrantFiled: April 20, 2001Date of Patent: May 24, 2005Assignee: Degussa AGInventors: Bettina Möckel, Walter Pfefferle, Achim Marx
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Publication number: 20050089976Abstract: The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.Type: ApplicationFiled: June 22, 2004Publication date: April 28, 2005Applicant: Degussa AGInventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
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Patent number: 6875586Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity. The invention also relates to isolating the luxR gene and which encode a LuxR transcriptional activator from Corynebacterium glutamicum.Type: GrantFiled: July 13, 2001Date of Patent: April 5, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
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Publication number: 20050064551Abstract: The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.Type: ApplicationFiled: May 5, 2004Publication date: March 24, 2005Applicant: DEGUSSA AGInventors: Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
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Publication number: 20050032179Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is: a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, or b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, or c) polynucleotide which is complementary to the polynucleotides of a) or b), or d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ccpA1 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.Type: ApplicationFiled: July 22, 2004Publication date: February 10, 2005Applicant: DEGUSSA AGInventors: Bettina Moeckel, Caroline Kreutzer
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Publication number: 20050003423Abstract: The present invention relates to polynucleotides corresponding to the lysR3 gene and which encode a LysR3 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.Type: ApplicationFiled: July 6, 2004Publication date: January 6, 2005Applicant: DEGUSSA AGInventors: Bettina Moeckel, Caroline Kreutzer
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Patent number: 6838267Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is: a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, or b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, or c) polynucleotide which is complementary to the polynucleotides of a) or b), or d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ccpA1 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.Type: GrantFiled: August 27, 2001Date of Patent: January 4, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer
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Patent number: 6830921Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), a process for the fermentative preparation of L-amino acids with enhancement of the acp gene and the use of the polynucleotide as a primer or hybridization probe.Type: GrantFiled: May 10, 2001Date of Patent: December 14, 2004Assignee: Degussa AGInventors: Bettina Möckel, Anke Weissenborn, Walter Pfefferle, Hermann Sahm, Lothar Eggeling, Madhavan Nampoothiri
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Patent number: 6825029Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.Type: GrantFiled: May 3, 2002Date of Patent: November 30, 2004Assignee: Degussa AGInventors: Laurence K. Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bernd Moritz, Lothar Eggeling, Hermann Sahm, Bettina Möckel, Anke Weissenborn
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Patent number: 6825030Abstract: The present invention is related to nucleotide sequences encoding a sensor kinse, citA, from Corynebacterium glutamicum.Type: GrantFiled: March 13, 2001Date of Patent: November 30, 2004Assignee: Degussa AGInventors: Bettina Möckel, Mike Farwick, Thomas Hermann, Achim Marx, Walter Pfefferle
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Patent number: 6812006Abstract: The present invention relates to polynucleotides corresponding to the lysR3 gene and which encode a LysR3 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.Type: GrantFiled: December 11, 2001Date of Patent: November 2, 2004Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer