Patents by Inventor Bettina Moeckel

Bettina Moeckel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050233373
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metH gene is present in enhanced form, and use of the polynucleotide sequences as hybridization probes.
    Type: Application
    Filed: June 20, 2005
    Publication date: October 20, 2005
    Applicant: DEGUSSA AG
    Inventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Patent number: 6949374
    Abstract: The invention relates to a genetically modified coryneform bacterium, the fadD15 gene of which is amplified, and an isolated polynucleotide which codes for acyl-CoA synthase from coryneform bacteria, and also a method for the fermentative preparation of L-amino acids with amplification of the fadD15 gene in the bacteria and the use of the polynucleotide as a primer or hybridization probe.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: September 27, 2005
    Assignee: Degussa AG
    Inventors: Madhavan Nampoothiri K., Bettina Möckel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm
  • Patent number: 6942996
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID. No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and p1 d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metE gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: September 13, 2005
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Patent number: 6939694
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the citB gene, and a host-vector system having a coryneform host bacterium in which the citB gene is present in attenuated form and a vector which carries at least the citB gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: September 6, 2005
    Inventors: Bettina Möckel, Thomas Hermann, Mike Farwick, Walter Pfefferle, Achim Marx
  • Patent number: 6939695
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: September 6, 2005
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Brigitte Bathe, Stefan Hans, Caroline Kreutzer, Thomas Hermann, Walter Pfefferle, Michael Binder
  • Patent number: 6913908
    Abstract: The present invention relates lo an isolated polynucleotide from Corynebacterium glutamicum comprising a polynucleotide sequence chosen from the group c insisting of (a) a polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO: 2; (b) a polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide which is complementary to the polynucleotides of(a) or (b), and (d) a polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the sigE gene is present in enhanced form, and the use of polynucleotides which comprise the sequence according to the invention as hybridization probes.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: July 5, 2005
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Thoams Hermann, Mike Farwick, Michael Binder, Walter Pfefferle
  • Patent number: 6913910
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising: a) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No.2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive bases of the polynucleotide sequence of a), b) or c), and processes for the fermentative production of L-amino acids by enhancement of the glk-gene coding for the enzyme glucokinase.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 5, 2005
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Walter Pfefferle
  • Publication number: 20050130264
    Abstract: The present invention relates to polynucleotides corresponding to the rpoB gene and which encode the ?-subunit of RNA polymerase B, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having activity of the ?-subunit of RNA polymerase B.
    Type: Application
    Filed: January 15, 2004
    Publication date: June 16, 2005
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Brigitte Bathe, Thomas Hermann, Walter Pfefferle, Michael Binder
  • Patent number: 6902916
    Abstract: The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR1 transcriptional regulator activity.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: June 7, 2005
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
  • Patent number: 6897055
    Abstract: The invention relates to polynucleotides that contain polynucleotide sequences coding for the genes sucC and sucD, selected from the group a) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 3, c) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No. 2, d) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: May 24, 2005
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Walter Pfefferle, Achim Marx
  • Publication number: 20050089976
    Abstract: The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.
    Type: Application
    Filed: June 22, 2004
    Publication date: April 28, 2005
    Applicant: Degussa AG
    Inventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
  • Patent number: 6875586
    Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity. The invention also relates to isolating the luxR gene and which encode a LuxR transcriptional activator from Corynebacterium glutamicum.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: April 5, 2005
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
  • Publication number: 20050064551
    Abstract: The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 24, 2005
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Publication number: 20050032179
    Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is: a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, or b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, or c) polynucleotide which is complementary to the polynucleotides of a) or b), or d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ccpA1 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
    Type: Application
    Filed: July 22, 2004
    Publication date: February 10, 2005
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Caroline Kreutzer
  • Publication number: 20050003423
    Abstract: The present invention relates to polynucleotides corresponding to the lysR3 gene and which encode a LysR3 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.
    Type: Application
    Filed: July 6, 2004
    Publication date: January 6, 2005
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Caroline Kreutzer
  • Patent number: 6838267
    Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is: a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, or b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, or c) polynucleotide which is complementary to the polynucleotides of a) or b), or d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ccpA1 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: January 4, 2005
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Caroline Kreutzer
  • Patent number: 6830921
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), a process for the fermentative preparation of L-amino acids with enhancement of the acp gene and the use of the polynucleotide as a primer or hybridization probe.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: December 14, 2004
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Anke Weissenborn, Walter Pfefferle, Hermann Sahm, Lothar Eggeling, Madhavan Nampoothiri
  • Patent number: 6825029
    Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: November 30, 2004
    Assignee: Degussa AG
    Inventors: Laurence K. Dunican, Ashling McCormack, Cliona Stapelton, Kevin Burke, Bernd Moritz, Lothar Eggeling, Hermann Sahm, Bettina Möckel, Anke Weissenborn
  • Patent number: 6825030
    Abstract: The present invention is related to nucleotide sequences encoding a sensor kinse, citA, from Corynebacterium glutamicum.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: November 30, 2004
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Mike Farwick, Thomas Hermann, Achim Marx, Walter Pfefferle
  • Patent number: 6812006
    Abstract: The present invention relates to polynucleotides corresponding to the lysR3 gene and which encode a LysR3 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: November 2, 2004
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Caroline Kreutzer