Abstract: The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate via the use of individual pumps to deposit individual wet film products onto a substrate.

Abstract: The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.

Abstract: The present invention provides processes and systems for preparing self-supporting film-forming compositions. The process generally includes the steps of: (a) providing a self-supporting film-forming matrix including an edible polymer component and a fluid carrier selected from the group consisting of water organic solvents and combinations thereof: (b) degassing the matrix via the steps of: (i) directing a flow of the matrix having a first density through at least one volume reduction device: and (ii) increasing the density of the matrix to form a second density. The present invention further includes the addition of actives to the matrix so as to provide an active-containing degassed film forming matrix.

Abstract: The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate, the substrate having at least one dam portion.

Abstract: The present invention relates to a system and method for dispensing a therapeutically effective amount of dosage containing a medicament including an instrument for inputting data from a user, analyzing the inputted data to determine an appropriate amount of medicament to be administered to the user, and a dispenser for sizing and dispensing a therapeutically effective amount of the medicament. The medicament may be in the form of a continuous roll of oral thin film including the medicament.

Abstract: The present invention relates to a method of optimizing self-supporting film production which includes the steps of: determining at least one scrap factor which relates to a total amount of scrap in processing a film product; correlating the at least one scrap factor to at least one processing parameter; and adjusting the at least one processing parameter to reduce the total amount of scrap in processing the film product.

Abstract: The present invention provides a safe and effective package for housing a dosage, which is easily opened by a user yet provides a secure and contaminant-free environment for the dosage housed within. The package may include a guided tear condition extending along at least one edge of the package, allowing a user to safely and effectively open the package without risk of compromising the dosage housed therein. In some embodiments, the dosage is a substantially flat dosage, such as a film.

Abstract: The present invention provides a process for making an edible film having a substantially uniform distribution of components, which includes the steps of combining a water-based film polymer solution and a slurry-type mixture comprising a water-active component and a solvent; mixing the polymer solution and slurry-type mixture for about 10 minutes or less; dispensing the mixed solution and slurry-type mixture to form a film; and drying the film to evaporate the water and solvent. Films made by the process are also provided.

Abstract: Compositions and methods for maintaining healthy mobile joints and cartilage in humans and animals are disclosed. The composition comprises glucosamine and chondroitin dispersed in a controlled-release matrix system capable of releasing the glucosamine and chondroitin over a designated time period. In another aspect, the invention provides compositions and methods for maintaining health mobile joints and cartilage in humans and animals without adversely affecting glucose regulation.

Abstract: Compositions and methods for maintaining healthy mobile joints and cartilage in humans and animals are disclosed. The composition comprises a glucosamine component dispersed in a controlled-release matrix system capable of releasing the glucosamine over a designated time period. In another aspect, the invention provides compositions and methods for maintaining health mobile joints and cartilage in humans and animals without adversely affecting glucose regulation.

Abstract: Compositions and methods of treatment for conditions in humans and animals which have an inflammatory component, are disclosed. The composition comprises a glucosamine component dispersed in a controlled-release matrix system capable of releasing the glucosamine over a designated time period. In another aspect, the invention provides compositions and methods for the treatment of arthritis in humans and animals without adversely effecting glucose regulation.

Abstract: The present invention is a unique process and apparatus for making a new matrix material called a shearform matrix which results in transformation of the morphology of a feedstock. The process is characterized by increasing the temperature of a nonsolubilized feedstock carrier to a point where it will undergo internal flow, followed by upwardly ejecting a stream of the feedstock and then subjecting it to disruptive fluid shear force which separates it into separate parts or masses which have a transformed morphology. The shearform matrix may include other ingredients such as oleaginous material and actives.

Abstract: A spinner head provides for the production of melt-spun product. The spinner head includes a base and a cover spaced from the base. A plurality of discrete spaced apart elongate heating elements are positioned between the base and the cover and define a chamber for accommodating feedstock material therein. An elongate generally annular housing having plural circumferentially spaced cylindrical passages extending therethrough is positionable over the heating elements. The housing defines a plurality of circumferentially spaced fins projecting radially inward. Each of the fins have tapered sidewalls which generally converge as the fin extends radially inward. The sidewalls of adjacent fins cooperate to define longitudinal radially-directed slots between the cylindrical passages so as to permit passage of the feedstock material therethrough.

Abstract: An apparatus and method for continuously making chopped amorphous fibers that uses an air transport system. The apparatus includes a source of floss, a duct for transporting the floss while it is entrained in a stream of gaseous carrier medium, a chopper for chopping the floss, and a separator. In a preferred embodiment, the floss is chopped while it is entrained in the stream of gaseous carrier medium using a rotating ring chopper, and the chopped floss is subsequently separated using a cyclone separator.

Abstract: A material processing apparatus for thermo flow melt spinning having temperature control characteristics. The apparatus includes a spinner head with a chamber that has a continuous perimeter for centrifugal force and a heater element substantially continuous with the perimeter for providing heat to the head. The spinner head includes means for rotating and a power source connected to the heater element. The apparatus includes temperature detecting means integral with the heater element to detect a processing temperature and generate a temperature detection signal accordingly. Also included is a power controller for controlling the power source in accordance with the temperature detection signal. The processing temperature may be controlled such that a substantially constant temperature is maintained.

Abstract: An apparatus for continuously making chopped amorphous fibers that uses an air transport system. The apparatus includes a source of floss, a duct for transporting the floss while it is entrained in a stream of gaseous carrier medium, a chopper for chopping the floss, and a separator. In a preferred embodiment, the floss is chopped while it is entrained in the stream of gaseous carrier medium using a rotating ring chopper, and the chopped floss is subsequently separated using a cyclone separator.

Abstract: A material processing apparatus and method for flash flow processing by melt spinning. The invention includes a feed rate controller in combination with a spinner head assembly including a spinner head with a continuous perimeter for providing heat and centrifugal force to a material being processed. The spinner head assembly also includes a spinner drive connected to the spinner head for generating the centrifugal force. The material processing apparatus can also include support for supporting the spinner head assembly, where the feed rate controller is electrically connected to the support. The feed rate controller determines a detected load of material in the spinner head from data provided by the support, compares it to a preselected load for the material being processed and generates a feed rate control signal indicative of a difference between the detected and preselected loads. A feeder assembly supplies the feedstock material to the spinner head at a feed rate defined by the feed control signal.

Abstract: An apparatus for spinning materials, such as thermo-flow materials, is disclosed. The apparatus includes a spinner head which is rotatable about an axis. The spinner head includes a heater assembly having an annular heater element, a removable controlled orifice band having a plurality of openings through its thickness and positioned around and in close proximity to the heater element and an annular support ring positioned around the controlled orifice band for holding the heater element and band within the spinner head.

Abstract: A material processing apparatus for flash flow processing by melt spinning includes a feed rate controller in combination with a spinner head assembly including a spinner head with a continuous perimeter for providing heat and centrifugal force to a material being processed. The spinner head assembly also includes a spinner drive connected to the spinner head for generating the centrifugal force. The material processing apparatus can also include support for supporting the spinner head assembly, where the feed rate controller is electrically connected to the support. The feed rate controller determines a detected load of material in the spinner head from data provided by the support, compares it to a preselected load for the material being processed and generates a feed rate control signal indicative of a difference between the detected and preselected loads. A feeder assembly supplies the feedstock material to the spinner head at a feed rate defined by the feed control signal.

Abstract: A double lumen, single needle, catheter is provided having an improved insertion tip which aleviates the trauma induced when inserted in a blood vessel or fistula.