Patents by Inventor Bin Shao

Bin Shao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7678809
    Abstract: Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: March 16, 2010
    Assignee: Purdue Pharma L.P.
    Inventors: Donald Kyle, Richard R. Goehring, Bin Shao
  • Publication number: 20100048626
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 25, 2010
    Inventors: Bin SHAO, R. Richard Goehring, Samuel F. Victory, Qun Sun
  • Publication number: 20100022595
    Abstract: The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: April 13, 2007
    Publication date: January 28, 2010
    Applicant: Purdue Pharma L.P.
    Inventors: Zhengming Chen, Khondaker Islam, Donald J. Kyle, Deyou Sha, Bin Shao, Jiangchao Yao, Xiaoming Zhou
  • Publication number: 20090306136
    Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: April 13, 2007
    Publication date: December 10, 2009
    Inventors: Akira Matsumura, Hidenori Mikamiyama, Bin Shao, Naoki Tsuno, Jiangchao Yao
  • Publication number: 20090298878
    Abstract: The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: July 12, 2007
    Publication date: December 3, 2009
    Inventors: Akira Matsumura, Hidenori Mikamiyama, Naoki Tsuno, Donald J. Kyle, Bin Shao, Jiangchao Yao
  • Publication number: 20090297618
    Abstract: The present invention provides a formula food comprising lutien, zeaxanthin, zinc, and selenium beneficial for eye health and its application. The formula food is not only applied for dietary supplement tablets and capsules, but also applied for various formula milk powders, various functional beverages, various baked food. The formula food is conducive to the human eye health, especially beneficial for the improvement of visuognosis persistence of human eyes, helpful for asthenopia remission and the improvement of eye consciousness symptoms.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 3, 2009
    Inventors: Xinde Xu, Di Zhou, Lihua Zhang, Bin Shao
  • Publication number: 20090291947
    Abstract: The present invention relates to Proline Analog Compounds that are ligands for cannabinoid receptors, compositions comprising a Proline Analog Compound and a pharmaceutically-acceptable carrier, methods of making such Proline Analog Compounds, and methods for treating or preventing a Condition comprising administering an effective amount of a Proline Analog Compound to an animal in need thereof.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 26, 2009
    Applicant: Purdue Pharma L.P.
    Inventors: Bin Shao, Jiangchao Yao
  • Publication number: 20090239910
    Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: March 29, 2007
    Publication date: September 24, 2009
    Inventors: Zhengning Chen, Khondaker Islam, Bin Shao, Jiangchao Yao, Xiaoming Zhou, Donald J. Kyle
  • Publication number: 20090220640
    Abstract: The present invention provides a method of supplementing animals with carotenoids by drinking water, comprising the following steps of: (1) making yellow and/or red pigments into the microencapsulated dry powders or beadlets; (2) mixing the aforementioned microencapsulated dry powders or beadlets in a certain proportion and dissolving them in water to prepare for a pigment solution; (3) administering the prepared pigment solution to animals by drinking. The method of supplementing the carotenoids according to the present invention has the advantages of easy absorption, economical dosages of pigments, high efficiency of coloration, stable coloration and small effects on the process of pigments in comparison with conventional methods currently.
    Type: Application
    Filed: November 14, 2008
    Publication date: September 3, 2009
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Chunbo Chen, Yimin Hong
  • Patent number: 7579367
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: August 25, 2009
    Assignee: Purdue Pharma L.P.
    Inventors: Bin Shao, R. Richard Goehring, Samuel F. Victory
  • Patent number: 7570116
    Abstract: An output stage, comprising a first transistor operable to pull a voltage at an output node towards a first voltage, and a rechargeable energy store having a potential difference between first and second terminals wherein the rechargeable energy store is arranged to be controllably connected between the output node and a second voltage supply such that the voltage at the output node can be driven to a voltage outside of a range defined between the first and second voltages.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: August 4, 2009
    Assignee: Analog Devices, Inc.
    Inventors: Olli Haila, Song Qin, Bin Shao
  • Patent number: 7485738
    Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: February 3, 2009
    Assignee: Zhejiang Medicine Co., Ltd., XinChang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
  • Patent number: 7456198
    Abstract: Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: November 25, 2008
    Assignee: Purdue Pharma L.P.
    Inventors: Donald Kyle, R. Richard Goehring, Bin Shao
  • Publication number: 20080278234
    Abstract: An output stage, comprising a first transistor operable to pull a voltage at an output node towards a first voltage, and a rechargeable energy store having a potential difference between first and second terminals wherein the rechargeable energy store is arranged to be controllably connected between the output node and a second voltage supply such that the voltage at the output node can be driven to a voltage outside of a range defined between the first and second voltages.
    Type: Application
    Filed: May 10, 2007
    Publication date: November 13, 2008
    Applicant: Analog Devices, Inc.
    Inventors: Olli Haila, Song Qin, Bin Shao
  • Publication number: 20080214827
    Abstract: Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
    Type: Application
    Filed: February 2, 2005
    Publication date: September 4, 2008
    Applicant: EURO-CELTIQUE S.A.
    Inventors: R. Richard Goehring, John Whitehead, Bin Shao
  • Publication number: 20080194627
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1—R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Application
    Filed: September 11, 2006
    Publication date: August 14, 2008
    Applicant: Euro-Celtique S.A.
    Inventors: Bin Shao, R. Goehring, Samuel Victory
  • Publication number: 20080081932
    Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
    Type: Application
    Filed: September 18, 2007
    Publication date: April 3, 2008
    Applicants: Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
  • Patent number: 7271298
    Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: September 18, 2007
    Assignee: Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen
  • Publication number: 20070032683
    Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
    Type: Application
    Filed: January 23, 2006
    Publication date: February 8, 2007
    Applicant: Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen
  • Publication number: 20070010554
    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1—R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Application
    Filed: September 11, 2006
    Publication date: January 11, 2007
    Applicant: Euro-Celtique S.A.
    Inventors: Bin Shao, R. Goehring, Samuel Victory