Patents by Inventor Blanka Sharma

Blanka Sharma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11179416
    Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 23, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Blanka Sharma, Isaac Adjei, Shreedevi Kumar
  • Patent number: 10993919
    Abstract: Compositions and methods are disclosed herein to deliver and anchor nanoscale drug carriers into the extracellular matrix (ECM) of tissues, such as degenerating cartilage or tumor margins, and to provide local and sustained release of drugs.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 4, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Blanka Sharma, Shannon B. Brown
  • Publication number: 20200390806
    Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.
    Type: Application
    Filed: February 20, 2019
    Publication date: December 17, 2020
    Inventors: Blanka SHARMA, Isaac ADJEI, Shreedevi KUMAR
  • Publication number: 20200390807
    Abstract: The present invention provides manganese dioxide nanoparticles complexed with one or more nucleic acid sequences for introduction into NK cells for an immunotherapy treatment. The nanoparticles discussed herein target and silence TGF-? in order to reactivate NK cells that have been inactivated or suppressed. Provided is a method of inducing an anti-cancer immune response in a subject, comprising administering to immune cells of the subject a pharmaceutically effective amount of a nanoparticle composition comprising a manganese dioxide nanoparticle complexed with a nucleic acid sequence in an amount sufficient to induce, enhance, or promote an immune response against the cancer in the subject. The invention also comprises a manganese dioxide nanoparticle formulation, comprising the manganese dioxide nanoparticle(s) as described and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 20, 2019
    Publication date: December 17, 2020
    Inventors: Isaac ADJEI, Blanka SHARMA
  • Publication number: 20190224132
    Abstract: Compositions and methods are disclosed herein to deliver and anchor nanoscale drug carriers into the extracellular matrix (ECM) of tissues, such as degenerating cartilage or tumor margins, and to provide local and sustained release of drugs.
    Type: Application
    Filed: October 3, 2017
    Publication date: July 25, 2019
    Inventors: Blanka Sharma, Shannon B. Brown
  • Publication number: 20050069572
    Abstract: A multi-layered tissue construct includes: a first layer comprising a first hydrogel; and a second layer comprising a second hydrogel, wherein the first layer is connected to the second layer at a first transition zone and wherein at least one of the first layer and the second layer further comprises a component selected from the group consisting of cells and a bioactive substance. Another multi-layered tissue construct includes: a first layer comprising a first hydrogel; a second layer comprising cells of a first type, wherein the second layer is disposed on the first layer; and a third layer comprising a second hydrogel and optionally cells of the first type encapsulated in the second hydrogel, wherein the third layer is disposed on the second layer. Methods for producing these multi-layered tissue constructs are also disclosed.
    Type: Application
    Filed: October 9, 2003
    Publication date: March 31, 2005
    Inventors: Christopher Williams, Blanka Sharma, Jennifer Elisseeff