Abstract: Analgesic and anti-inflamatory compounds of the formula ##STR1## wherein n=0-1,X=Halo, lower Alkoxy, HO--, Lower Alkyl, andR= ##STR2##

Abstract: New iodophor compositions are provided which are mixtures of polydextrose-iodine and polyvinylpyrrolidone-iodine. Such mixtures containing polydextrose-iodine and polyvinylpyrrolidone-iodine, wherein the ratio by weight of polydextrose to polyvinylpyrrolidone is between 20-80: 80-20, have an immediate bactericidal activity upon application and also a long lasting microbicidal activity. The immediate microbicidal acitivity is faster and more effective than by the use of either the polydextrose-iodine alone or the polyvinylpyrrolidone-iodine alone, and the effect is more long lasting than in the case of the use of either polydextrose-iodine alone or polyvinylpyrrolidone-iodine alone.

Abstract: New iodophors are provided which exhibit effective degerming of skin, nucous membranes of animals and surfaces of inanimate objects and which provide broad spectrum microbicidal action without toxicity or irritation. The iodophors of the invention are complexes of iodine with polydextrose or with the polymer resulting from the copolymerization of sucrose and epichlorohydrin. The invention further relates to germicidal compositions containing such complexes and to methods of producing the complexes.

Abstract: Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR.sub.5, --CH.sub.2 CO.sub.2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl;R.sub.5 =lower alkyl;R.sub.1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle;R.sub.2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl;R.sub.3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle;R.sub.2 and R.sub.3 together form a ring;R.sub.4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R.sub.1 and R.sub.4 may form a ring; ##STR3## --CH.sub.2 --; Y=--S--CHR.sub.4 --, --O--OHR.sub.4 --,--CHR.sub.4 --, --CR.sub.6 R.sub.7 --CHR.sub.4, ##STR4## wherein R.

Abstract: New iodophors are provided which exhibit effective degerming of skin, mucous membranes of animals and surfaces of inanimate objects and which provide broad spectrum microbicidal action without toxicity or irritation. The iodophors of the invention are complexes of iodine with polydextrose or with the polymer resulting from the copolymerization of sucrose and epichlorohydrin. The invention further relates to germicidal compositions containing such complexes and to methods of producing the complexes.

Abstract: Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR.sub.5, --CH.sub.2 CO.sub.2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl;R.sub.5 =lower alkyl;R.sub.1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle;R.sub.2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl;R.sub.3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle;R.sub.2 and R.sub.3 together form a ring;R.sub.4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R.sub.1 and R.sub.4 may form a ring;X=>C.dbd.O, --CH.sub.2 --;Y=--S--CHR.sub.4 --, --O--OHR.sub.4 --, --CHR.sub.4 --, --CR.sub.6 R.sub.7 --CHR.sub.

Abstract: The invention relates to compounds which exhibit diuretic and antihypertensive properties and have the following structures: ##STR1## or pharmaceutically acceptable salts thereof, wherein: X=halogen or trifluoromethylY.sub.1 and Y.sub.2 =independently hydrogen, alkyl, acyl, aryl, substituted aryl or heterocycle,R.sub.1 =hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle or substituted heterocycle,n=O or an integer from 1-4R.sub.2 =amino, substituted amino, guanidino, substituted guanidino, halogen, alkyl, substituted alkyl, aryl, substituted aryl or heterocycle, andR.sub.3 =hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle, substituted heterocycle or acyl.

Abstract: Antimicrobial compounds of the formulae: ##STR1## wherein R and R.sub.1 =H, lower alkyl, halogen, methoxy, hydroxy, nitro, carboxy, aryl (preferably phenyl) substituted aryl (preferably substituted by lower alkyl) and sulfamyl, R.sub.2 =hydrogen, lower alkyl, aryl (preferably phenyl) and substituted aryl (preferably substituted by lower alkyl) and wherein n is an integer from 2-20, are provided. Also provided are the method of producing such compounds.

Abstract: Antimicrobial compounds of the formulae: ##STR1## wherein R and R.sub.1 =H, lower alkyl, halogen, methoxy, hydroxy, nitro, carboxy, aryl (preferably phenyl) substituted aryl (preferably substituted by lower alkyl) and sulfamyl, and R.sub.2 =hydrogen, lower alkyl, aryl (preferably phenyl) and substituted aryl (preferably substituted by lower alkyl) and wherein n is an integer from 2-20, are provided. Also provided are the method of producing such compounds.

Abstract: Compounds of the general formula: ##STR1## and pharmaceutical acceptable salts thereof wherein R is H, lower alkyl, lower alkenyl, lower aralkenyl, cycloalkyl-alkyl, propargyl, lower aralkyl, hydroxyalkyl and esters thereof, heterocyclic, heterocyclic-alkyl, alkyl-aminoalkyl, adamantylalkyl, aralkyl-heterocyclic-alkyl and alkyl-aralkyl-heterocyclic alkyl;R.sup.1 is H, lower alkyl, phenyl, or phenylloweralkyl;R.sup.2 is hydrogen or lower alkyl;R.sup.3 is hydrogen; lower alkoxy; lower alkoxy alkyl ether of hydroxy; amino; lower alkyl; halogen; nitro; hydroxy; or carboxylic acid ester of hydroxy group, which compounds are useful as analgesics, narcotic antagonists and antihistaminics.

Abstract: Compounds of the general formula: ##STR1## and pharmaceutical acceptable salts thereof wherein R is H, lower alkyl, lower alkenyl, lower aralkenyl, cycloalkyl-alkyl, propargyl, lower aralkyl, hydroxyalkyl and esters thereof, heterocyclic, heterocyclic-alkyl, alkyl-aminoalkyl, adamantylalkyl, aralkyl-heterocyclic-alkyl and alkyl-aralkyl-heterocyclic alkyl;R.sup.1 is H, lower alkyl, phenyl, or phenylloweralkyl;R.sup.2 is hydrogen or lower alkyl;R.sup.3 is hydrogen; lower alkoxy; lower alkoxy alkyl ether of hydroxy; amino; lower alkyl; halogen; nitro; hydroxy; or carboxylic acid ester of hydroxy group, useful as analgesics and narcotic antagonists.

Abstract: 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones, acid addition salts thereof, and intermediate compounds having analgesic properties. A representative quinazolinone compound is 1-[2-(1-phenyl-4-piperazinyl)-ethyl]-2-phenyl-1,2,3,4-tetrahydro-4-quinazo linone. A representative analgesic intermediate is 2-[2-(4-[1-phenyl]piperazinyl)ethylamino] bezamide.