Patents by Inventor Boris V. Zemelman

Boris V. Zemelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7144733
    Abstract: Cells are rendered sensitive to stimulation by introducing into a non-photoreceptor cell nucleic acid sequences encoding at least an opsin gene product, an arrestin gene product, and the alpha subunit of the heterotrimeric G protein of the Gq family. The introduced sequences are expressed by the cell to yield at least the opsin gene product, the arrestin gene product, and the alpha subunit of the heterotrimeric G protein of the Gq family. Retinal or a derivative thereof capable of bonding with the opsin gene product to form a rhodopsin is provided to the cell. The cell is then irradiated with light having a wavelength capable of converting the rhodopsin to metarhodopsin. The conversion of rhodopsin to metarhodopsin triggers a cascade of intracellular responses within the cell resulting in an increased intracellular concentration of IP3 and calcium ions.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: December 5, 2006
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Gero Miesenböck, Boris V. Zemelman
  • Publication number: 20030040080
    Abstract: Method for rendering a cell sensitive to stimulation. In a preferred embodiment, the method comprises introducing, into a cell, nucleic acid sequences encoding at least an opsin gene product, an arrestin gene product, and the alpha subunit of the heterotrimeric G protein of the Gq family. The introduced nucleic acid sequences are then expressed by the non-photoreceptor cell to yield at least the opsin gene product, the arrestin gene product, and the alpha subunit of the heterotrimeric G protein of the Gq family. Retinal or a derivative thereof capable of bonding with the opsin gene product to form a rhodopsin is then provided to the non-photoreceptor cell. The non-photoreceptor cell is then irradiated with light having a wavelength capable of converting the rhodopsin to metarhodopsin. The conversion of rhodopsin to metarhodopsin triggers a cascade of intracellular responses within the cell resulting in an increased intracellular concentration of IP3 and calcium ions leading to an action potential in the cell.
    Type: Application
    Filed: August 16, 2002
    Publication date: February 27, 2003
    Inventors: Gero Miesenbock, Boris V. Zemelman