Patents by Inventor Bradford E. Gliner

Bradford E. Gliner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8926676
    Abstract: Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: January 6, 2015
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Alvaro Pascual-Leone, Bradford E. Gliner, David Himes, Leif R. Sloan
  • Patent number: 8504159
    Abstract: Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: August 6, 2013
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Brad Fowler, Bradford E. Gliner, David Himes
  • Publication number: 20130066391
    Abstract: The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is selected based in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
    Type: Application
    Filed: September 7, 2012
    Publication date: March 14, 2013
    Inventors: Justin Hulvershorn, Bradford E. Gliner, Brian Kopell
  • Patent number: 8262714
    Abstract: The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: September 11, 2012
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Justin Hulvershorn, Bradford E. Gliner, Brian Kopell
  • Patent number: 8090446
    Abstract: Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: January 3, 2012
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Brad Fowler, Justin Hulvershorn, Bradford E. Gliner, Leif R. Sloan
  • Publication number: 20110213440
    Abstract: Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
    Type: Application
    Filed: May 10, 2011
    Publication date: September 1, 2011
    Inventors: Brad Fowler, Bradford E. Gliner, David Himes
  • Patent number: 7949401
    Abstract: Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: May 24, 2011
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Brad Fowler, Bradford E. Gliner, David Himes
  • Publication number: 20100036453
    Abstract: The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
    Type: Application
    Filed: February 27, 2009
    Publication date: February 11, 2010
    Applicant: Northstar Neuroscience, Inc.
    Inventors: Justin Hulvershorn, Bradford E. Gliner, Brian Kopell
  • Publication number: 20090099622
    Abstract: Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes.
    Type: Application
    Filed: April 8, 2008
    Publication date: April 16, 2009
    Applicant: Northstar Neuroscience, Inc.
    Inventors: Brad Fowler, Justin Hulvershorn, Bradford E. Gliner, Leif R. Sloan
  • Publication number: 20080208285
    Abstract: Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure.
    Type: Application
    Filed: December 20, 2007
    Publication date: August 28, 2008
    Applicant: Northstar Neuroscience, Inc.
    Inventors: Brad Fowler, Bradford E. Gliner, W. Douglas Sheffield, Leif R. Sloan
  • Publication number: 20080139870
    Abstract: Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
    Type: Application
    Filed: December 12, 2006
    Publication date: June 12, 2008
    Applicant: Northstar Neuroscience, Inc.
    Inventors: Bradford E. Gliner, Brad Fowler, Justin Hulvershorn, Leif R. Sloan
  • Patent number: 7079894
    Abstract: A defibrillator capable of delivering a damped biphasic truncated (DBT) defibrillation pulse is provided. An energy storage circuit is coupled across a high voltage switch such as an H-bridge for delivering a defibrillation pulse to the patient through a pair of electrodes. A controller operates to control the entire defibrillation process and detects shockable rhythms from the patient via an ECG front end. The energy storage circuit consists of an energy storage capacitor, a series inductor, a shunt diode, and optionally a resistor in series with the inductor. The controller measures as the patient dependent parameter the time interval between the initial delivery of the defibrillation pulse and the occurrence of the peak current or voltage to determine the first and second phases of the defibrillation pulse to provide for compensation for patient impedance.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: July 18, 2006
    Assignee: Koninklijke Philips Electronics, N.V.
    Inventors: Thomas D. Lyster, Bradford E. Gliner, Daniel J. Powers
  • Patent number: 7010351
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: March 7, 2006
    Assignee: Northstar Neuroscience, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford E. Gliner, Alan J. Levy, Carlton B. Morgan
  • Patent number: 6990377
    Abstract: System and methods for effectuating and/or facilitating visual function in a patient. One embodiment of a system comprises a neural stimulation system and a visual training system. The neural stimulation system can include a pulse generator and a stimulus delivery device coupled to the pulse generator. The stimulus delivery device is configured to deliver a stimulus to the brain of the patient. The visual training system can include a computer and a display coupled to the computer. The computer has a computer operable medium containing instructions to provide a visual output to the patient via the display.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: January 24, 2006
    Assignee: Northstar Neuroscience, Inc.
    Inventors: Bradford E. Gliner, Warren D. Sheffield
  • Patent number: 6671547
    Abstract: An electrotherapy device including at least one sensor operable to sense at least one physiological parameter of a patient. A controller is operably connected to the at least one sensor operable to receive signals from the at least one sensor corresponding to the at least one physiological parameter. Memory is operable to store computer-programming code executed by the controller. The programming code includes decision-making criteria operable to adapt a patient treatment in response changes to the detected at least one physiological parameter. At least one pair of electrodes is operably connected to the controller and operable to administer the treatment to the patient.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: December 30, 2003
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Thomas D. Lyster, Carlton B. Morgan, Gust H. Bardy, Bradford E. Gliner
  • Publication number: 20030097161
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Application
    Filed: November 12, 2002
    Publication date: May 22, 2003
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford E. Gliner, Alan J. Levy, Carlton B. Morgan
  • Patent number: 6553256
    Abstract: This invention relates generally to a device for monitoring an infant for the onset of sudden infant death syndrome (SIDS), detecting the onset of SIDS and providing immediate treatment. In the broadest sense, the invention includes an apparatus for detecting and treating SIDS. The apparatus comprises a data gatherer for monitoring an infant parameter, a controller for communicating with the data gatherer, an energy source operable to power the data gatherer for monitoring the infant parameter and further operable to provide energy to an energy delivery system which is operable to deliver an electric shock from an energy source to an electrode interface, and an alarm which is activated by the controller for alerting a remote caregiver to the onset of symptoms associated with SIDS. The invention also relates to a method of operating a SIDS monitor. The method comprises the steps of monitoring an infant parameter, determining whether the monitored parameter is an acceptable value.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: April 22, 2003
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Dawn Blilie Jorgenson, Bradford E Gliner
  • Publication number: 20020193848
    Abstract: An electrotherapy device including at least one sensor operable to sense at least one physiological parameter of a patient. A controller is operably connected to the at least one sensor operable to receive signals from the at least one sensor corresponding to the at least one physiological parameter. Memory is operable to store computer-programming code executed by the controller. The programming code includes decision-making criteria operable to adapt a patient treatment in response changes to the detected at least one physiological parameter. At least one pair of electrodes is operably connected to the controller and operable to administer the treatment to the patient.
    Type: Application
    Filed: June 13, 2001
    Publication date: December 19, 2002
    Inventors: Thomas D. Lyster, Carlton B. Morgan, Gust H. Bardy, Bradford E. Gliner
  • Publication number: 20020161408
    Abstract: A defibrillator capable of delivering a damped biphasic truncated (DBT) defibrillation pulse is provided. An energy storage circuit is coupled across a high voltage switch such as an H-bridge for delivering a defibrillation pulse to the patient through a pair of electrodes. A controller operates to control the entire defibrillation process and detects shockable rhythms from the patient via an ECG front end. The energy storage circuit consists of an energy storage capacitor, a series inductor, a shunt diode, and optionally a resistor in series with the inductor. The controller measures as the patient dependent parameter the time interval between the initial delivery of the defibrillation pulse and the occurrence of the peak current or voltage to determine the first and second phases of the defibrillation pulse to provide for compensation for patient impedance.
    Type: Application
    Filed: April 17, 2002
    Publication date: October 31, 2002
    Applicant: Koninklijke Philips Electronics N.V.
    Inventors: Thomas D. Lyster, Bradford E. Gliner, Daniel J. Powers
  • Publication number: 20020087201
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Application
    Filed: March 8, 2001
    Publication date: July 4, 2002
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford E. Gliner, Alan J. Levy, Carlton B. Morgan