Abstract: A method and system for detecting paving material segregation in a paving material supply chain includes at least a paving material plant, a paving material haul truck, and a paver machine. The method and system further includes receiving segregation information from a plurality of cameras located in the paving material supply chain and identifying a location of segregation formation in the supply chain based on the received segregation information.

Abstract: A paving machine can include a frame; a screed coupled to the frame, the screed including one or more screed plates; one or more movable extender mechanisms located at a back end of each screed plate and configured to extend and retract up and down beneath the screed plate; and a controller configured to extend the one or more extender mechanisms a pre-determined distance before the screed begins a paving operation and to retract the one or more extender mechanisms after the screed has begun the paving operation.

Abstract: An illumination control system for a mobile machine that operates in coordination with other mobile machines is configured to adjust an illumination lamp disposed on the mobile machine and directed in a travel direction of the machine. The illumination control system includes a positioning/location device that can determine a proximity distance between the mobile machine and a second mobile machine approaching in the travel direction. The illumination control system also includes an electronic controller configured to adjust the illumination device based on the proximity distance as determined. The illumination control system may find particular usefulness in paving and/or milling operations.

Abstract: A screed assembly associated with a machine includes a screed disposed at a rear end of the machine and at least one control panel assembly coupled to the screed. The at least one control panel assembly includes a control panel including a recess and a support structure adapted to be removably coupled with the control panel. The support structure includes a first structure defining a first axis. The first structure is movable along the first axis and rotatable about the first axis. The support structure also includes a second structure movably coupled to the first structure. The second structure defines a second axis substantially parallel to the first axis. The second structure is rotatable about the second axis and includes a locking member adapted to be slidably received within the recess of the control panel for removably coupling the control panel with the support structure.

Abstract: A steering console system for a machine includes a longitudinally-extending rail configured to be fastened to a surface of the machine, the rail including a pair of convex-shaped edges, a steering console, and a console carriage slidably connected to the rail, the console carriage including a bracket, a plurality of rollers connected to the bracket, a support arm connected to the bracket to support the steering console, and a vertical pivot connected to the bracket and to the support arm. Each of the rollers has a concave groove configured to roll along the convex shaped edges, and each of the rollers is configured to rotate about an axis of rotation extending approximately normal with respect to the rail.

Abstract: An illumination control system for a mobile machine that operates in coordination with other mobile machines is configured to adjust an illumination lamp disposed on the mobile machine and directed in a travel direction of the machine. The illumination control system includes a positioning/location device that can determine a proximity distance between the mobile machine and a second mobile machine approaching in the travel direction. The illumination control system also includes an electronic controller configured to adjust the illumination device based on the proximity distance as determined. The illumination control system may find particular usefulness in paving and/or milling operations.

Abstract: A steering console system for a machine includes a longitudinally-extending rail configured to be fastened to a surface of the machine, the rail including a pair of convex-shaped edges, a steering console, and a console carriage slidably connected to the rail, the console carriage including a bracket, a plurality of rollers connected to the bracket, a support arm connected to the bracket to support the steering console, and a vertical pivot connected to the bracket and to the support arm. Each of the rollers has a concave groove configured to roll along the convex shaped edges, and each of the rollers is configured to rotate about an axis of rotation extending approximately normal with respect to the rail.

Abstract: A screed assembly associated with a machine includes a screed disposed at a rear end of the machine and at least one control panel assembly coupled to the screed. The at least one control panel assembly includes a control panel including a recess and a support structure adapted to be removably coupled with the control panel. The support structure includes a first structure defining a first axis. The first structure is movable along the first axis and rotatable about the first axis. The support structure also includes a second structure movably coupled to the first structure. The second structure defines a second axis substantially parallel to the first axis. The second structure is rotatable about the second axis and includes a locking member adapted to be slidably received within the recess of the control panel for removably coupling the control panel with the support structure.

Abstract: Provided herein are pyranonaphthoquinone compounds and methods of using pyranonaphthoquinone compounds. The method of using the pyranonaphthoquinone compounds includes selectively inhibiting 4E-BP1 phosphorylation by administering at least one pyranonaphthoquinone or pyranonaphthoquinone analog to a subject in need thereof.

Abstract: A paving machine having a frame extending along a longitudinal direction is provided. The frame defines a front portion, a rear portion and two lateral sides. A hopper is coupled to the front portion of the frame. A screed is coupled to the rear portion of the frame. A conveyor is configured to transfer a paving material from the hopper to the screed along the longitudinal direction. The paving machine includes two pairs of ground engaging members of different types and powered independently of each other, one pair of ground engaging members being disposed towards the front portion and other pair of ground engaging members being disposed towards the rear portion of the frame.

Abstract: A paving machine including a right hopper, a left hopper, an apron and an automated hopper and apron control system is provided. The right hopper, the left hopper and the apron are configured to move in a vertically upward and downward direction. The automated hopper and apron control system is configured to control the movement of one or more of the right hopper, the left hopper, and the apron. The automated hopper and apron control system may include a controller. The controller is configured to operate the automated hopper and apron control system in a manual mode and an auto mode as desired by an operator. In the auto mode, the controller actuates one or more of the right hopper, the left hopper, and the apron from a first position to one of a fully raised position and a fully lowered position.

Abstract: A paving machine including an adjustable screed assembly is provided. Actuators adjust the screed assembly into the plurality of different configurations. Sensors sense a respective configuration parameter indicative of the configuration of the screed assembly. A controller is configured to save a first set of parameters including the configuration parameters and save a second set of parameters including the configuration parameters in response. The controller is configured to recall one of the first set or second set of parameters, and adjust automatically the configuration of the screed assembly to correspond to the configuration parameters included in the recalled first set or second set of parameters.

Abstract: A paving machine including a right hopper, a left hopper, an apron and an automated hopper and apron control system is provided. The right hopper, the left hopper and the apron are configured to move in a vertically upward and downward direction. The automated hopper and apron control system is configured to control the movement of one or more of the right hopper, the left hopper, and the apron. The automated hopper and apron control system may include a controller. The controller is configured to operate the automated hopper and apron control system in a manual mode and an auto mode as desired by an operator. In the auto mode, the controller actuates one or more of the right hopper, the left hopper, and the apron from a first position to one of a fully raised position and a fully lowered position.

Abstract: A paving machine including an adjustable screed assembly is provided. Actuators adjust the screed assembly into the plurality of different configurations. Sensors sense a respective configuration parameter indicative of the configuration of the screed assembly. A controller is configured to save a first set of parameters including the configuration parameters and save a second set of parameters including the configuration parameters in response. The controller is configured to recall one of the first set or second set of parameters, and adjust automatically the configuration of the screed assembly to correspond to the configuration parameters included in the recalled first set or second set of parameters.

Abstract: A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes preparing a solution of the camptothecin, wherein the solution has a pH which places substantially an entirety of that camptothecin in a carboxylate form. The camptothecin may be a neutral camptothecin. The solution is next loaded into a liposome including at least one lipid, which may be a phospholipid. An intraliposomal pH is maintained which preserves substantially an entirety of the camptothecin in the carboxylate form. The liposomal dispersion is administered to an individual in need thereof, whereby the liposomes accumulate at and permeate into tumor tissue and an active, lactone form camptothecin is released in situ at the tumor site. Compositions formulated in accordance with the described method for treatment of a cancer in an animal in need thereof are provided also.

Abstract: A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes preparing a solution of the camptothecin, wherein the solution has a pH which places substantially an entirety of that camptothecin in a carboxylate form. The camptothecin may be a neutral camptothecin. The solution is next loaded into a liposome including at least one lipid, which may be a phospholipid. An intraliposomal pH is maintained which preserves substantially an entirety of the camptothecin in the carboxylate form. The liposomal dispersion is administered to an individual in need thereof, whereby the liposomes accumulate at and permeate into tumor tissue and an active, lactone form camptothecin is released in situ at the tumor site. Compositions formulated in accordance with the described method for treatment of a cancer in an animal in need thereof are provided also.

Abstract: Disclosed herein is a liposomal formulation that comprises a liposome and a liquid carrier. In the liposomal formulation, the liposome comprises a hydrophobic lactone drug and has an intraliposomal metal ion concentration higher than the metal ion concentration of the liquid carrier. Also disclosed herein is a method for active loading of a hydrophobic lactone drug into a liposome. The method includes preparing a liposome in the presence of a metal salt solution, an acid form of a counterion of the metal salt being membrane permeable, such that the liposome preparation contains entrapped metal ion. The method further includes forming a liposome with high intraliposomal pH by separating extravesicular metal salt solution from the liposome by exposing the liposome to a metal salt-free solution, resulting in diffusion of the acid form of the counterion out of the liposome and formation of an intraliposomal pH higher than that of the metal salt-free solution.