Patents by Inventor Brian A. Fox

Brian A. Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8231866
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: July 31, 2012
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Brian A. Fox, Kevin M. Klucher, David W. Taft, Wayne Kindsvogel
  • Patent number: 8217008
    Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: July 10, 2012
    Assignee: ZymoGenetics, Inc.
    Inventors: Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Cameron S. Brandt, Mark W. Rixon, Scott R. Presnell, Brian A. Fox
  • Publication number: 20120142612
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: January 19, 2012
    Publication date: June 7, 2012
    Inventors: Paul O. Sheppard, Brian A. Fox, Kevin M. Klucher, David W. Taft, Wayne Kindsvogel
  • Publication number: 20120112786
    Abstract: A method for testing a set of circuitry in an integrated circuit (IC) is described. The IC includes multiple configurable circuits for configurably performing multiple operations. The method configures the IC to operate in a user mode with a set of test paths that satisfies a set of evaluation criteria. Each test path includes a controllable storage element for controllably storing a signal that the storage element receives. The method operates the IC in user mode. The method reads the values stored in the storage elements to determine whether the set of circuitry is operating within specified performance limits.
    Type: Application
    Filed: November 7, 2011
    Publication date: May 10, 2012
    Inventor: Brian Fox
  • Patent number: 8124065
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: February 28, 2012
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Brian A. Fox, Kevin M. Klucher, David W. Taft, Wayne Kindsvogel
  • Publication number: 20120036590
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: September 8, 2011
    Publication date: February 9, 2012
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • Patent number: 8084230
    Abstract: The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: December 27, 2011
    Assignee: ZymoGenetics, Inc.
    Inventors: Margaret Dow Moore, Brian A. Fox
  • Patent number: 8072234
    Abstract: A method for testing a set of circuitry in an integrated circuit (IC) is described. The IC includes multiple configurable circuits for configurably performing multiple operations. The method configures the IC to operate in a user mode with a set of test paths that satisfies a set of evaluation criteria. Each test path includes a controllable storage element for controllably storing a signal that the storage element receives. The method operates the IC in user mode. The method reads the values stored in the storage elements to determine whether the set of circuitry is operating within specified performance limits.
    Type: Grant
    Filed: May 23, 2010
    Date of Patent: December 6, 2011
    Assignee: Tabula, Inc.
    Inventor: Brian Fox
  • Patent number: 8067652
    Abstract: The invention relates to a process for forming a polyalphaolefin, the process comprising the step of polymerizing at least one C8-C12 monomer, preferably a decene such as 1-decene, in the presence of an aluminoxane, an activator and a metallocene to form the polyalphaolefin, wherein the molar ratio of the aluminoxane to the metallocene is less than 250:1. The invention also relates to a process for forming a polyalphaolefin having a desired kinematic viscosity from at least one monomer in the presence of an aluminoxane, an organoboron compound and a metallocene. The process comprises the steps of, inter alia, providing a correlation between (i) the molar ratio of the aluminoxane to at least one of the organoboron compound and the metallocene, and (ii) the kinematic viscosity of the polyalphaolefin to form polyalphaolefins having predictable viscosities.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: November 29, 2011
    Assignee: Chemtura Corporation
    Inventors: Willie C. Bburton, E. Brian Fox
  • Publication number: 20110217291
    Abstract: Disclosed are soluble hybrid Fc? receptor (Fc?R) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid Fc?R polypeptides.
    Type: Application
    Filed: June 29, 2009
    Publication date: September 8, 2011
    Inventors: Carl W. Birks, Brian A. Fox, Mark W. Rixon, Jeff L. Ellsworth
  • Publication number: 20110195916
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: February 15, 2011
    Publication date: August 11, 2011
    Inventors: Paul O. Sheppard, Brian A. Fox, Kevin M. Klucher, David W. Taft, Wayne Kindsvogel
  • Publication number: 20110172170
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: March 2, 2011
    Publication date: July 14, 2011
    Inventors: PAUL O. SHEPPARD, SCOTT R. PRESNELL, BRIAN A. FOX, TERESA GILBERT, BETTY A. HALDEMAN, FRANCIS J. GRANT
  • Patent number: 7943807
    Abstract: The invention relates to a polyalphaolefin formed from a decene and propene and having a branch level greater than 19% and to a process for forming such polyalphaolefins. The invention also relates to a process for forming a polyalphaolefin from at least two monomers, the two monomers comprising a decene and propene, the process comprising the steps of, inter alia, providing a correlation between the total amount of propene used to form the polyalphaolefin and at least one of branch level or viscosity of the polyalphaolefin to make polyalphaolefins comprising decene and propene with predictable branch levels and viscosities.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: May 17, 2011
    Assignee: Chemtura Corporation
    Inventors: Willie Charles Burton, E. Brian Fox
  • Publication number: 20110092752
    Abstract: The invention is directed to polyalphaolefins (PAOs) and processes for forming PAOs. In one embodiment, the invention is to a process for forming a PAO comprising polymerizing C8-C12 ?-olefin monomers in the presence of hydrogen, a C8-C12 saturated hydrocarbon, e.g., a C8-C12 saturated straight-chain hydrocarbon, and a catalyst system in a reaction vessel, wherein the C8-C12 saturated straight-chain hydrocarbon has about the same number of carbon atoms as the C8-C12 ?-olefin monomers. The C8-C12 saturated straight-chain hydrocarbon optionally is derived from a crude PAO product formed by the process of the invention. The invention is also directed to reaction systems for performing the processes of the invention, to processes for controlling PAO viscosity based on residence time, and to the removal of spent catalyst using a solid adsorbent particles.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 21, 2011
    Inventors: Daniel C. Knowles, Jesus R. Fabian, Vilan Kosover, Susan Ferrarotti, E. Brian Fox, Frank DeBlase
  • Publication number: 20110081346
    Abstract: Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.
    Type: Application
    Filed: November 10, 2010
    Publication date: April 7, 2011
    Inventors: CAMERON S. BRANDT, JACOB J. KENNEDY, WENFENG XU, EUGENE C. YI, BRIAN A. FOX, ZEREN GAO, PALLAVUR V. SIVAKUMAR
  • Publication number: 20110081345
    Abstract: The present invention relates generally to scFc molecules. The scFc molecules comprise at least two Fc regions and at least one linker, and can be produced in a variety of single chain configurations. The scFc molecules can further comprise at least one binding entity and/or at least one functional molecule. Binding entities can be fused to the scFc molecule in a variety of configurations. The present invention also relates generally to methods for making such molecules and methods for their use. The scFc molecules provided herein can be recombinantly produced. Also provided are monovalent forms of the scFc molecules that have an equivalent or superior ADCC and/or CDC response than do bivalent molecules targeting the same antigens. Provided herein are improved antigen binding compositions.
    Type: Application
    Filed: November 8, 2010
    Publication date: April 7, 2011
    Inventors: Margaret D. Moore, Marshall D. Snavely, Brian A. Fox
  • Patent number: 7919595
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: April 5, 2011
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • Publication number: 20110068820
    Abstract: A method for testing a set of circuitry in an integrated circuit (IC) is described. The IC includes multiple configurable circuits for configurably performing multiple operations. The method configures the IC to operate in a user mode with a set of test paths that satisfies a set of evaluation criteria. Each test path includes a controllable storage element for controllably storing a signal that the storage element receives. The method operates the IC in user mode. The method reads the values stored in the storage elements to determine whether the set of circuitry is operating within specified performance limits.
    Type: Application
    Filed: May 23, 2010
    Publication date: March 24, 2011
    Inventor: Brian Fox
  • Patent number: 7910313
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: March 22, 2011
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Brian A. Fox, Kevin M. Klucher, David W. Taft, Wayne R. Kindsvogel
  • Publication number: 20110054148
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 3, 2011
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Halderman, Francis J. Grant