Patents by Inventor Brian Hargreaves

Brian Hargreaves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040214868
    Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a 1
    Type: Application
    Filed: June 1, 2004
    Publication date: October 28, 2004
    Inventors: Barry Raymond Hayter, Gordon Stuart Currie, Rodney Brian Hargreaves, Roger James, Clifford David Jones, Darren McKerrecher, Joanne Victoria Allen, Peter William Rodney Caulkett, Craig Johnstone, Harold Gaskin
  • Patent number: 6787556
    Abstract: The present invention relates to the use of certain benzoic acid derivatives of formula (I), as disclosed in the specification, which act as peroxisome proliferator activated receptor (PPAR) agonists, in particular states of insulin resistance including type 2 gamma receptors (PPAR), and so are useful therapeutically in the treatment of diabetes mellitus. Novel pharmaceutical compositions and novel compounds are also defined, together with methods of their production.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: September 7, 2004
    Assignee: AstraZeneca AB
    Inventors: Rodney Brian Hargreaves, Paul Robert Owen Whittamore
  • Patent number: 6219571
    Abstract: A new technique for imaging a material with a high T2/T1 ratio such as articular cartilage uses driven equilibrium Fourier transform (DEFT), a method of enhancing signal strength without waiting for full T1 recovery. Compared to other methods, DEFT imaging provides a good combination of bright cartilage and high contrast between cartilage and surrounding tissue. Both theoretical predictions and images show that DEFT is a valuable method for imaging articular cartilage when compared to spoiled gradient recalled acquisition in the steady-state (SPGR) or fast spin echo (FSE). T2-decay, T1 recovery, echo time, magnetization density, proton density, and equilibrium density per proton are related by a derived equation.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 17, 2001
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Dwight G. Nishimura
  • Patent number: 5654298
    Abstract: This invention concerns novel aminopyridinium compounds of the formula I wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are selected from the following combinations: ##STR1## (a) one of R.sup.2 and R.sup.6 is a basic group selected from amino, alkylamino, dialkylamino of up to eight carbon atoms, pyrrolidino, piperidino and morpholino, or is alkyl, alkenyl, alkoxyalkyl, alkoxy, alkylthio, phenyl, phenylalkyl, cycloalkyl or cycloalkylalkyl; and the other of R.sup.2 and R.sup.6 is hydrogen, alkyl or one of the above defined basic groups;R.sup.1 is alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl, cycloalkylalkyl; and R.sup.3 and R.sup.5 are independently hydrogen, alkyl or alkenyl;(b) R.sup.2 is a basic group as defined above, R.sup.5 and R.sup.6 together form alkylene or, together with the appendant carbon atoms of the pyridine ring, complete a benzene ring; has any of the meanings defined in(a) above; and R.sup.3 is hydrogen, alkyl or alkenyl; and(c) R2 has any of the meanings defined above and R.sup.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: August 5, 1997
    Assignee: Imperial Chemical Industries
    Inventors: Stuart Dennett Mills, Rodney Brian Hargreaves, Bernard Joseph McLoughlin
  • Patent number: 4825154
    Abstract: A current probe is provided which comprises a handle and a ring of magnetisable material for positioning around an electrical conductor, the ring being split into two portions one being fixed relative to the handle and the other being slidable therewithin between a position in which the ring is closed and a position in which the ring is open. The line of split of the ring is at an angle from the line of sliding movement of the linearly slidable portion. Damping is provided to prevent the slidable portion of the ring from too rapidly moving from a position in which the ring is open to a position in which the ring is closed.
    Type: Grant
    Filed: February 5, 1987
    Date of Patent: April 25, 1989
    Assignee: Pilkington Brothers PLC
    Inventors: Geoffrey Cross, Brian Hargreaves
  • Patent number: 4631209
    Abstract: In a method of making asbestos-free friction facing material in the form of a water-laid sheet of cellulosic fibres, in which are distributed friction-imparting particles and particles of friction-modifier, the sheet containing a thermosetting phenolic resin which after curing binds the ingredients firmly together, the thermosetting phenolic resin is included in emulsified form in the aqueous suspension of ingredients from which the water-laid sheet is prepared.This leads to a product of more consistent friction performance than is obtained by post-sheeting impregnation with thermosetting phenolic resin.
    Type: Grant
    Filed: August 8, 1985
    Date of Patent: December 23, 1986
    Assignees: Ferodo Ltd., T&N Research Ltd.
    Inventors: Ralph Baker, Eric T. Smith, Vaughan T. Dickinson, Noel C. McKenzie, Brian Hargreaves
  • Patent number: 4529662
    Abstract: Non-asbestos flexible sheet material suitable for use in the manufacture of spiral wound gaskets is made by dewatering on a water-permeable conveyor a layer of aqueous slurry and compressing and drying the dewatered layer, the aqueous slurry employed being one that contains the following ingredients in the following proportions by dry weight:china clay 20-50%mica or chlorite 20-50%graphite 10-40%cellulose fibres 2-10%vitreous fibre in wool form 2-10%synthetic organic polymer binder 2-10%.
    Type: Grant
    Filed: November 10, 1983
    Date of Patent: July 16, 1985
    Assignee: T&N Materials Research Limited
    Inventors: Robert A. Lancaster, Noel C. McKenzie, Brian Hargreaves
  • Patent number: 4529653
    Abstract: Non-asbestos flexible sheet material suitable for use in gaskets for the exhaust manifold of an internal combustion engine is made by dewatering on a water-permeable conveyor a layer of aqueous slurry and compressing and drying the dewatered layer, the aqueous slurry employed being one that contains the following ingredients in the following proportions by dry weight:ball clay: 25-44%non-fibrous layer silicate: 25-40%graphite: 10-30%cellulose fibres: 3-15%synthetic rubber: 1-10%starch: 1-5%.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: July 16, 1985
    Assignee: T&N Materials Research Limited
    Inventors: Brian Hargreaves, Robert A. Lancaster, Noel C. McKenzie, John D. Crabtree
  • Patent number: 4529663
    Abstract: Non-asbestos flexible sheet material suitable for use in gaskets for the cylinder head of an internal combustion engine is made by dewatering on a water-permeable conveyor a layer of aqueous slurry and compressing and drying the dewatered layer, the aqueous slurry employed being one that contains the following ingredients in the following proportions by dry weight:______________________________________ ball clay 25-44% calcium silicate of high specific 15-40% surface area cellulose fibres 3-15% organic polymer binder 5-15% fibrillated poly (aromatic amide) 1-15% fibres ______________________________________
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: July 16, 1985
    Assignee: T&N Materials Research Limited
    Inventors: Robert A. Lancaster, Noel C. McKenzie, Brian Hargreaves
  • Patent number: 4378271
    Abstract: Non-asbestos alternatives to starch-bound asbestos papers comprise a matrix of unfired ball clay which is reinforced by vitreous fibres derived from wool-form materials and by organic web-forming fibres, the whole being bound together by hydrolysed starch.
    Type: Grant
    Filed: October 10, 1980
    Date of Patent: March 29, 1983
    Assignee: Turner & Newall PLC
    Inventors: Brian Hargreaves, Robert A. Lancaster, Brian Healey, Alan K. Cousens
  • Patent number: 4363847
    Abstract: Flexible sheet material suitable for use in the manufacture of gaskets has a basis (85-95% by weight) of fine particles of a non-fibrous charged-layer-silicate mineral such as chlorite and includes a minor proportion (at least 2% but not more than 15% by weight of the material) of organic web-forming fibers, preferably cellulose fibers. The fine particles of the silicate mineral and the web-forming fibers are bound together with a synthetic rubber.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: December 14, 1982
    Assignee: AMFU Limited
    Inventors: Brian Hargreaves, Alan K. Cousens
  • Patent number: 4220066
    Abstract: Glass scoring apparatus comprises a cutting tool, means for applying a cutting load to the cutting tool when the tool engages a glass surface to be scored, and a damping member arranged to absorb energy developed by reaction forces opposing the cutting load when the tool is moved into contact with the glass. The damping member has a loss factor tan .delta. which is high enough to prevent any substantial transient reduction in the cutting load.
    Type: Grant
    Filed: August 2, 1978
    Date of Patent: September 2, 1980
    Assignee: Pilkington Brothers Limited
    Inventors: Brian Hargreaves, Angus D. Duncan
  • Patent number: 4136142
    Abstract: Crystal polystyrene is satisfactorily protected against oxidative degradation in foam extrusion processes and thermoforming of articles from the expanded product so formed, by incorporation therein of a combined stabilizer system, comprising from about 0.01 to about 0.5 parts by weight of a hindered phenol compound such as 1,1,3-tris(2-methyl-4-hydroxy-5-tert.butyl phenyl) butane, and from about 0.02 to about 1.0 parts by weight of a tris (substituted phenyl) phosphite such as tris (mixed mono- and dinonylphenyl phosphite), based upon 100 parts by weight of polystyrene. Such stabilized foamed crystal polystyrene may be used for the production of formed articles.
    Type: Grant
    Filed: March 23, 1977
    Date of Patent: January 23, 1979
    Assignee: Polysar Limited
    Inventors: Brian Hargreaves, Michael H. Richmond