Patents by Inventor Bruce Alan ARMITAGE

Bruce Alan ARMITAGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced biomolecule detection assays based on tyramide signal amplification and gammaPNA probes
    Patent number: 11124822
    Abstract: Provided herein are methods of detecting target analytes, such as nucleic acids, for example microRNAs using an enhanced Tyramide Signal Amplification (TSA) method that employs probes tagged with tyramide-binding groups to amplify the effects of the TSA. The accessibility of the tyramide-binding groups, such as hydroxyphenyl groups, provides for large improvements in signal due to faster reaction with the radicals. The present invention further includes the application of the assay for detecting specific microRNAs.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 21, 2021
    Assignee: Carnegie Mellon University
    Inventors: Bruce Alan Armitage, Veronica Hinman, Munira F. Fouz
  • Enhanced Biomolecule Detection Assays Based on Tyramide Signal Amplification and gammaPNA Probes
    Publication number: 20170226572
    Abstract: Provided herein are methods of detecting target analytes, such as nucleic acids, for example microRNAs using an enhanced Tyramide Signal Amplification (TSA) method that employs probes tagged with tyramide-binding groups to amplify the effects of the TSA. The accessibility of the tyramide-binding groups, such as hydroxyphenyl groups, provides for large improvements in signal due to faster reaction with the radicals. The present invention further includes the application of the assay for detecting specific microRNAs.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 10, 2017
    Inventors: Bruce Alan ARMITAGE, Veronica HINMAN, Munira F. FOUZ