Patents by Inventor Bruce D. Jensen

Bruce D. Jensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5667764
    Abstract: Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective delivery of therapeutic agents, and retention thereof at the selected site.Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian cancer; and (4) psoriasis.
    Type: Grant
    Filed: May 15, 1992
    Date of Patent: September 16, 1997
    Assignee: Zynaxis, Inc.
    Inventors: Gregory A. Kopia, Paul K. Horan, Brian D. Gray, David E. Troutner, Katharine A. Muirhead, Kamleshkumar A. Sheth, Chia-En Lin, Zhizhou Yu, Bruce D. Jensen, Sue Ellen Slezak
  • Patent number: 5665328
    Abstract: Compounds, compositions, their methods of preparation and use in binding bio-affecting substances to the surface membrane of bioparticles, such as enkaryotic cells, without producing appreciable detrimental effect on morphology or physiological function of cells.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: September 9, 1997
    Assignee: Phanos Technologies, Inc.
    Inventors: Paul Karl Horan, Sue Ellen Slezak, Bruce D. Jensen
  • Patent number: 5385822
    Abstract: The presence or quantity of a selected subset of cells, which is part of a subpopulation of a mixed cell population, is determined by a method in which a detectable reporter substance is uniformly incorporated into substantially all cells of the subpopulation containing the subset of interest. The subset of interest is then affinity-separated by incubating a test sample of the mixed cell population containing the labeled subpopulation with a specific binding substance which selectively binds to characteristic determinants of the cell subset of interest. Occurrence of the reporter substance in the separated fraction is then detected, and correlated to a predetermined standard to determine the presence or quantity of the subset of interest within the cell population. According to another aspect of the invention a method is provided for quantitating two or more selected subsets of cells within a subpopulation of a mixed cell population.
    Type: Grant
    Filed: November 29, 1990
    Date of Patent: January 31, 1995
    Assignee: Zynaxis, Inc.
    Inventors: Meryle J. Melnicoff, Bruce D. Jensen, Katharine A. Muirhead, Paul K. Horan, Martin D. Summers, William Wong
  • Patent number: 5374531
    Abstract: Methods and test kits are provided for the quantitative or qualitative determination of selected analytes, e.g., cell subsets in a mixed cell population, using a particulate separation reagent and a particulate detection reagent. The invention enables cell monitoring of AIDS patients in a efficient and reliable manner.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: December 20, 1994
    Assignee: Zynaxis, Inc.
    Inventor: Bruce D. Jensen
  • Patent number: 4859584
    Abstract: Methods for determining growth rate of cells growing in vivo and in vitro. Cells are labelled with cyanine dyes and changes in plasma membrane cyanine dye levels are used to determine growth rate. Cell growth rate determinations are utilized to monitor transplanted bone marrow cell engraftment and post-surgical corneal epitheal cell growth. The invented methods also are used to determine tumor cell sensitivity to cancer therapeutic agents, yeast sensitivity to antifungal agents, and bacteria sensitivity to antibacterial agents.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: August 22, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul K. Horan, Bruce D. Jensen, Sue E. Slezak
  • Patent number: 4783401
    Abstract: Methods for reproducibly labelling viable cells with cyanine dyes that do not significantly affect cell viability. Applications for labelled cells include using labelled red blood cells to distinguish post-transfusional bleeding from immunologic reaction and using dilution to measure growth rate of cultured cells.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: November 8, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul K. Horan, Bruce D. Jensen, Sue E. Slezak