Patents by Inventor Bruce E. Maryanoff

Bruce E. Maryanoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidinyl compounds that selectively bind integrins
    Patent number: 7879881
    Abstract: The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated disorder.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: February 1, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Bart De Corte, William A. Kinney, Bruce E. Maryanoff, Shyamali Ghosh, Li Liu
  • Inhibitors of chymase
    Patent number: 7872044
    Abstract: The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates and derivatives thereof, and methods for treating inflammatory or serine protease mediated disorders.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: January 18, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael Greco, Michael Hawkins, Eugene Powell, Bruce E. Maryanoff
  • SUBSTITUTED PYRROLINES AS KINASE INHIBITORS
    Publication number: 20100240650
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 23, 2010
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrroline kinase inhibitors
    Patent number: 7786135
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: August 31, 2010
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Patent number: 7781450
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: August 24, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Pyridine-containing macroheterococylic compounds as kinase inhibitors
    Patent number: 7759331
    Abstract: This invention is directed to pyridine-containing macroheterocyclic compounds useful as kinase inhibitors, methods for producing such compounds and methods for treating or preventing a kinase mediated disorder.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: July 20, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Han-Cheng Zhang, Llorente Vincente R. Bonaga, Claudia K. Derian, Bruce E. Maryanoff, Hong Ye
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7759380
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: July 20, 2010
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker
  • Isonipecotamides for the treatment of integrin-mediated disorders
    Patent number: 7718673
    Abstract: The invention is directed to novel isonipecotamide derivatives of Formula (I): which are useful in treating integrin-mediated disorders.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: May 18, 2010
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael J. Costanzo, William J. Hoekstra, Bruce E. Maryanoff
  • Substituted pyrroline kinase inhibitors
    Patent number: 7705015
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: April 27, 2010
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, David F. McComsey
  • Novel inhibitors of chymase
    Publication number: 20100048513
    Abstract: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: August 20, 2008
    Publication date: February 25, 2010
    Inventors: Michael J. Hawkins, Michael N. Greco, Eugene Powell, Lawrence de Garavilla, Bruce E. Maryanoff
  • UROTENSIN II RECEPTOR ANTAGONISTS
    Publication number: 20100029616
    Abstract: The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters and prodrugs thereof, pharmaceutical compositions containing compounds of formula (I) and the use of said compounds and compositions as urotensin II receptor antagonists.
    Type: Application
    Filed: July 31, 2009
    Publication date: February 4, 2010
    Inventors: William A. Kinney, Diane K. Luci, Bruce E. Maryanoff, Shyamali Ghosh, Edward C. Lawson
  • Heteroaryl peptidomimetics as thrombin receptor antagonists
    Patent number: 7629319
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: December 8, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, William J. Hoekstra, Kimberly White
  • Collagen-related peptides
    Publication number: 20090299034
    Abstract: The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.
    Type: Application
    Filed: August 1, 2007
    Publication date: December 3, 2009
    Inventors: Mabel Alamino Cejas, William A. Kinney, Bruce E. Maryanoff, Brett Tounge
  • Heteroaryl peptidomimetics as thrombin receptor antagonists
    Patent number: 7618945
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: November 17, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, William J. Hoekstra, Kimberly White
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7608634
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: October 27, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Triazolopyrimidine derivatives as ADP P2Yreceptor antagonists
    Patent number: 7566722
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein R1 and R2 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 28, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Cailin Chen
  • SUBSTITUTED PYRROLINE KINASE INHIBITORS
    Publication number: 20090181982
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: March 11, 2009
    Publication date: July 16, 2009
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • SUBSTITUTED PYRROLINE KINASE INHIBITORS
    Publication number: 20090176806
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: March 11, 2009
    Publication date: July 9, 2009
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Spiropiperidines for use as tryptase inhibitors
    Publication number: 20090163527
    Abstract: The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.
    Type: Application
    Filed: November 19, 2008
    Publication date: June 25, 2009
    Inventors: Michael J. Costanzo, Stephen C. Yabut, Brett Tounge, Bruce E. Maryanoff, Han-Cheng Zhang
  • Enantioselective process for preparing a substituted alkanoic acid
    Publication number: 20090124804
    Abstract: The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
    Type: Application
    Filed: October 30, 2008
    Publication date: May 14, 2009
    Inventors: William A. Kinney, Christopher A. Teleha, Shyamali Ghosh, Bruce E. Maryanoff