Patents by Inventor Bruce Joseph Roser

Bruce Joseph Roser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7803911
    Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: September 28, 2010
    Assignee: Quandrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Publication number: 20090149388
    Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.
    Type: Application
    Filed: February 13, 2009
    Publication date: June 11, 2009
    Inventor: Bruce Joseph ROSER
  • Patent number: 7501493
    Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: March 10, 2009
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7381796
    Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: June 3, 2008
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Publication number: 20080026066
    Abstract: Present proposals to use perfluorocarbons as a medium to suspend glass particles presents the problem of aggregation of the particles within the suspending medium. Overcoming this problem requires careful particle sizing and density matching techniques. An additional disadvantage of the large scale use of perfluorocarbons is their contribution to global warming. The inventor has realised that by replacing perfluorocarbons with the more environmentally friendly fluorinated ethers such as hydrofluoroethers or hydrofluoropolyethers a long lasting suspension of glass particles can be achieved without the need for such rigorous particle sizing or density matching processes.
    Type: Application
    Filed: April 13, 2005
    Publication date: January 31, 2008
    Applicant: CAMBRIDGE BIOSTABILITY LIMITED
    Inventor: Bruce Joseph ROSER
  • Patent number: 7253262
    Abstract: A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: August 7, 2007
    Assignee: Quandrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7244825
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: July 17, 2007
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7244824
    Abstract: A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: July 17, 2007
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7220836
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: May 22, 2007
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Publication number: 20040132656
    Abstract: A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Application
    Filed: October 8, 2003
    Publication date: July 8, 2004
    Applicant: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 6649386
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: November 18, 2003
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 6623762
    Abstract: The present invention is a pharmaceutical composition and method for controlling the release of a drug or vaccine to a patient where a slow, controlled release of drug or antigen occurs over a considerable period of time after injection. The drug or vaccine is contained in sugar glass microspheres and then placed in an anhydrous liquid, preferably perfluorocarbon, so that the vaccine is protected against dissolution while remaining surrounded by anhydrous liquid. This simple non-toxic system, deliverable by current syringe or present or future needle-free systems, is inexpensive and reliable and aids in parenteral drug delivery or mass immunization campaigns by reducing the need for repeated injections.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: September 23, 2003
    Assignee: Cambridge Biostability Ltd.
    Inventors: Bruce Joseph Roser, Arcadio Garcia De Castro
  • Patent number: 6602222
    Abstract: The present invention is a hand-operated injector device for injecting parenteral medications consisting of a cap, a plunger, a base, and a snap means. The cap contains a hollow central finger which upon proper hand force, moves toward a narrow plunger with an ability to slide into an annular wide plunger within an self-contained injection capsule. The movement of the cap drives the narrow plunger toward a narrow injection orifice at the bottom the capsule containing liquid medicament through which, the medicament under high pressure, forms a liquid jet through subcutaneous tissue of the patient. The injector may contain an external spring assisted holder or an internal spring assisted holder where the central finger is modified so as to be spring loaded. Finally, the spring injector may contain a cocking tab and a reusable power case. The injector device requires little training to use, reduces pain, improves injection safety and eliminates the need for a check valve.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: August 5, 2003
    Assignee: Cambridge Biostability Ltd.
    Inventor: Bruce Joseph Roser
  • Publication number: 20020155129
    Abstract: The present invention is a pharmaceutical composition and method For controlling the release of a drug or vaccine to a patient where a slow, controlled release of drug or antigen occurs over a considerable period of time after injection. The drug or vaccine is contained in sugar glass microspheres and then placed in an anhydrous liquid, preferably perfluorocarbon, so that the vaccine is protected against dissolution while remaining surrounded by anhydrous liquid. This simple non-toxic system, deliverable by current syringe or present or future needle-free systems, is inexpensive and reliable and aids in parenteral drug delivery or mass immunization campaigns by reducing the need for repeated injections.
    Type: Application
    Filed: February 16, 2001
    Publication date: October 24, 2002
    Inventor: Bruce Joseph Roser
  • Publication number: 20020128207
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60 DEG C.
    Type: Application
    Filed: October 30, 1998
    Publication date: September 12, 2002
    Inventor: BRUCE JOSEPH ROSER
  • Publication number: 20010051603
    Abstract: A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Application
    Filed: June 25, 2001
    Publication date: December 13, 2001
    Inventor: Bruce Joseph Roser
  • Patent number: 6224567
    Abstract: The present invention is a modified single use hand-operated injector device consisting of a plunger, a base, a snap means for resisting plunger movement and an injection means for injecting parenteral medication through a skin surface of a patient. The improvement comprises a check valve seated in a cannula and a widened receptacle area within a high pressure barrel through which the cannula passes. When the check-valve plug expels upon increase in pressure, into the widened receptacle area the parenteral medication efficiently flows around the plug and into the subcutaneous tissue of the patient.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: May 1, 2001
    Assignee: Cambridge Biostability Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 6190701
    Abstract: A composition for delivering a stable, bioactive compound to a subject comprising a first component and a second component, the first component comprises microparticles of sugar glass or a phosphate glass containing the bioactive agent. The sugar glass or phosphate glass optionally includes a glass formation facilitator compound, and the second component comprises at least one biocompatible liquid perfluorocarbon in which the first component is insoluble and dispersed. The liquid perfluorocarbon optionally includes a surfactant.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: February 20, 2001
    Assignee: Peter M. Ronai
    Inventors: Bruce Joseph Roser, Arcadio Garcia De Castro, James Maki
  • Patent number: 6102896
    Abstract: The present invention is a single use injector device for injecting parenteral medications which operates by hand force. The injector device has a plunger section and a base. As hand force is applied to a moving portion of the plunger section, break tabs or a snap ring resist its motion toward the patient's skin surface. The break tabs or snap ring release abruptly as the hand force reaches a snap point. The motion of the moving portion then drives the medication through the skin surface and into the body of the patient. If the medication is in liquid form, the actual injection may be carried out through a hollow needle attached to the plunger section. Alternatively, the suddenly increased pressure of the medication at the snap point may be used to form a liquid jet for needleless injection. Part or all of the medication may be contained in a glass needle which dissolves in the body after injection. The injector device requires little training to use, reduces perceived pain, and improves injection safety.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: August 15, 2000
    Assignee: Cambridge Biostability Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 6034080
    Abstract: Inhibitors of the Maillard reaction are useful in the treatment or prophylaxis of amyloidosis-based disease, particularly Alzheimer's disease. Particular examples include aminoguanidine and amphotericin B.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: March 7, 2000
    Assignee: Quadrant Holdings Cambridge Limited
    Inventors: Camilo Colaco, Bruce Joseph Roser