Abstract: The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

Abstract: The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

Abstract: The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

Abstract: The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

Abstract: The present invention is generally in the field of methods, compositions, and devices for reducing the incidence of mastitis in an animal. More specifically the invention includes methods and compositions for creating a physical barrier on the teat surface or in the teat canal of an animal for prophylactic treatment of mammary disorders. In one embodiment, the methods and compositions are designed for use during the animal's dry period. In one embodiment, the methods and compositions are designed for placement in the teat cistern. In one embodiment, the methods and compositions are designed for placement in adhering to the external teat.

Abstract: Methods for initiating formation of hydrogels in situ from a gellable composition and an initiator where the initiator is provided as a solid article or is contained in a solution infused to the intended site of formation of the hydrogel.

Abstract: A bone cement formed from a hydrogel formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer.

Abstract: Spinal disc implants containing one or more swellable articles such as dehydrated microspheres.

Abstract: A hydrogel string that is useful as a medical device and a method for forming a hydrogel string that utilizes a delivery device in which gelation of a prepolymer is initiated to form a hydrogel, which is then extruded from the device as the hydrogel string.

Abstract: A prosthetic spinal disc nucleus pulposus formed from a hydrogel formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer.

Abstract: Biomaterial formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer.

Abstract: Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and hydrolyzed copolymers of vinyl acetate, for example, copolymers with vinyl chloride, N-vinylpyrrolidone, etc. The backbone polymer contains pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as agents to hulk and coat tissues.

Abstract: Coaxial catheter delivery devices, methods to form coaxial microcatheters, and methods to deliver two part compositions, especially useful for formation of coaxial microcatheters for use in delivery of two part compositions to the neurovascular system.

Abstract: Methods for initiating formation of hydrogels in situ from a gellable composition and an initiator where the initiator is provided as a solid article or is contained in a solution infused to the intended site of formation of the hydrogel.

Abstract: A wound dressing is provided that is formed in situ on the wound by spray application of a composition including a composition that gels in situ to form a hydrogel. The composition preferably includes macromers having water soluble regions and crosslinkable regions. Compositions for making a hydrogel wound dressing are also provided.

Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.