Patents by Inventor Bryon A. Merrill

Bryon A. Merrill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZONAPHTHYRIDINES
    Publication number: 20050288320
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Application
    Filed: July 25, 2005
    Publication date: December 29, 2005
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalek, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • Amide substituted imidazopyridines
    Publication number: 20050282854
    Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: August 10, 2005
    Publication date: December 22, 2005
    Inventors: Philip Heppner, Kyle Lindstrom, Bryon Merrill
  • Treatment for lung cancer
    Publication number: 20050267145
    Abstract: The present invention provides methods, pharmaceutical compositions, and pharmaceutical combinations useful for treating lung cancer. Generally, the compositions include a 5-LO inhibitor in an amount effective to inhibit 5-lipoxygenase in an inhalable formulation. In some cases, the formulation may further include an IRM compound. Generally, the pharmaceutical combinations include a 5-LO inhibitor and an IRM compound in an inhalable formulation. Generally, the methods include administering to the subject an inhalable formulation that comprises a 5-lipoxygenase inhibitor having a cLogP of at least about 4.0 in an amount effective for treating lung cancer.
    Type: Application
    Filed: May 31, 2005
    Publication date: December 1, 2005
    Inventors: Bryon Merrill, Paul Myrdal, Paul Wightman
  • Amide substituted imidazopyridines
    Patent number: 6969722
    Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: November 29, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Philip D. Heppner, Kyle J. Lindstrom, Bryon A. Merrill
  • Thioether substituted imidazoquinolines
    Patent number: 6949649
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: September 27, 2005
    Assignee: 3M Innovative Properties Co.
    Inventors: Jason D. Bonk, Joseph F. Dellaria, Bryon A. Merrill, Matthew R. Radmer
  • Imidazonaphthyridines
    Patent number: 6949646
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: September 27, 2005
    Assignee: 3M Innovative Properties Co.
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Thioether substituted imidazoquinolines
    Patent number: 6921826
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: July 26, 2005
    Assignee: 3M Innovative Properties Co.
    Inventors: Joseph F. Dellaria, Bryon A. Merrill, Matthew R. Radmer
  • Sulfonamido ether substituted imidazoquinolines
    Publication number: 20050148619
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: February 28, 2005
    Publication date: July 7, 2005
    Inventors: Stephen Crooks, George Griesgraber, Philip Heppner, Bryon Merrill, Ralph Roberts, Ai-Ping Wei
  • Sulfonamido ether substituted imidazoquinolines
    Publication number: 20050148620
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: February 28, 2005
    Publication date: July 7, 2005
    Inventors: Stephen Crooks, George Griesgraber, Philip Heppner, Bryon Merrill, Ralph Roberts, Ai-Ping Wei
  • Amido ether substituted imidazoquinolines
    Publication number: 20050143413
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: February 28, 2005
    Publication date: June 30, 2005
    Inventors: Stephen Crooks, George Griesgraber, Philip Heppner, Bryon Merrill
  • Urea substituted imidazoquinolines
    Publication number: 20050131009
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: January 20, 2005
    Publication date: June 16, 2005
    Inventors: Stephen Crooks, George Griesgraber, Kyle Lindstrom, Bryon Merrill, Michael Rice
  • Urea substituted imidazopyridines
    Patent number: 6903113
    Abstract: Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: June 7, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Philip D. Heppner, Kyle J. Lindstrom, Bryon A. Merrill
  • Imidazonaphthyridines
    Publication number: 20050107421
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Application
    Filed: December 3, 2004
    Publication date: May 19, 2005
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalck, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • Imidazonaphthyridines
    Patent number: 6894165
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: May 17, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Sulfonamide and sulfamide substituted imidazoquinolines
    Patent number: 6888000
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: May 3, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
  • Amide substituted imidazoquinolines
    Publication number: 20040229897
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: May 19, 2004
    Publication date: November 18, 2004
    Applicant: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
  • Oxazolo, thiazolo and selenazolo [4,5-C]-quinolin-4-amines and analogs thereof
    Patent number: 6809203
    Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: October 26, 2004
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom, Gregory J. Marszalek, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Sulfonamide substituted imidazoquinolines
    Publication number: 20040204438
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: April 16, 2004
    Publication date: October 14, 2004
    Applicant: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, Bryon A. Merrill
  • Imidazonaphthyridines
    Publication number: 20040204436
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 14, 2004
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Sulfonamide and sulfamide substituted imidazoquinolines
    Patent number: 6800624
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: October 5, 2004
    Assignee: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice