Patents by Inventor Burkhard Klenke

Burkhard Klenke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITUS B VIRUS (HBV)
    Publication number: 20220306647
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 29, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Susanne BONSMANN, Alastair DONALD, Andreas URBAN, Burkhard KLENKE, Jasper SPRINGER
  • NOVEL PHENYL AND PYRIDYL UREAS ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220227785
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: July 21, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Susanne BONSMANN, Alastair DONALD, Burkhard KLENKE, Andreas URBAN, Jasper SPRINGER
  • Process for making substituted quinazoline compounds
    Patent number: 9890128
    Abstract: The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: February 13, 2018
    Assignees: MERCK SHARP & DOHME CORP., AICURIS ANTI-INFECTIVE CURES GMBH
    Inventors: Michael Luzung, Guy Humphrey, Bangping Xiang, Kevin M. Belyk, Stephen Mark Dalby, Wilfried Schwab, Burkhard Klenke, Tom Moody, Gareth Brown
  • Amidine substituted ?-lactam compounds, their preparation and use as antibacterial agents
    Patent number: 9782390
    Abstract: The present invention relates to novel ?-lactam compounds, their preparation and use. In particular, this invention relates to novel ?-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 10, 2017
    Assignee: AiCuris GmbH & Co. KG
    Inventors: Burkhard Klenke, Irith Wiegand, Guido Schiffer, Heike Broetz-Oesterhelt, Samarendra N. Maiti, Jehangir Khan, Andhe Reddy, Zhixiang Yang, Mostafa Hena, Guofeng Jia, Ou Ligong, Hong Liang, Judy Yip, Chuanjun Gao, Sabiha Tajammul, Rahim Mohammad, Ganguli Biswajeet
  • AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS
    Publication number: 20170100379
    Abstract: The present invention relates to novel ?-lactam compounds, their preparation and use. In particular, this invention relates to novel ?-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Burkhard KLENKE, Irith WIEGAND, Guido SCHIFFER, Heike BROETZ-OESTERHELT, Samarendra N. MAITI, Jehangir KHAN, Andhe REDDY, Zhixiang YANG, Mostafa HENA, Guofeng JIA, Ou LIGONG, Hong LIANG, Judy YIP, Chuanjun GAO, Sabiha TAJAMMUL, Rahim MOHAMMAD, Ganguli BISWAJEET
  • Amidine substituted -lactam compounds, their preparation and use as antibacterial agents
    Patent number: 9556165
    Abstract: The present invention relates to novel ?-lactam compounds, their preparation and use. In particular, this invention relates to novel ?-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: January 31, 2017
    Assignee: AiCuris GmbH & Co. KG
    Inventors: Burkhard Klenke, Irith Wiegand, Guido Schiffer, Heike Broetz-Oesterhelt, Samarendra N. Maiti, Jehangir Khan, Andhe Reddy, Zhixiang Yang, Mostafa Hena, Guofeng Jia, Ou Ligong, Hong Liang, Judy Yip, Chuanjun Gao, Sabiha Tajammul, Rahim Mohammad, Ganguli Biswajeet
  • PROCESS FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS
    Publication number: 20160311781
    Abstract: The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
    Type: Application
    Filed: December 8, 2014
    Publication date: October 27, 2016
    Inventors: Michael Luzung, Guy Humphrey, Bangping Xiang, Kevin M. Belyk, Stephen Mark Dalby, Wilfried Schwab, Burkhard Klenke, Tom Moody, Gareth Brown
  • Carboxamide-substituted heteroaryl-pyrazoles and the use thereof
    Patent number: 9296720
    Abstract: This invention relates to new carboxamide-substituted heteroaryl-pyrazoles, method for their production, their use for the treatment and/or prophylaxis of diseases, as well as their use for the production of pharmaceutical agents for the treatment and/or prophylaxis of diseases, in particular retroviral diseases, in humans and/or animals.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 29, 2016
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Steffen Wildum, Burkhard Klenke, Astrid Wendt
  • Tris(hetero)arylpyrazoles and use thereof
    Patent number: 9249148
    Abstract: The present invention relates to new tri(hetero)aryl pyrazoles, methods for their preparation, their use for treating and/or preventing diseases as well as their use in the preparation of drugs for treating and/or preventing diseases, in particular retroviral diseases in humans and/or animals.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: February 2, 2016
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Steffen Wildum, Burkhard Klenke, Astrid Wendt
  • TRIS(HETERO)ARYLPYRAZOLES AND USE THEREOF
    Publication number: 20150203500
    Abstract: The present invention relates to new tri(hetero)aryl pyrazoles, methods for their preparation, their use for treating and/or preventing diseases as well as their use in the preparation of drugs for treating and/or preventing diseases, in particular retroviral diseases in humans and/or animals.
    Type: Application
    Filed: August 16, 2013
    Publication date: July 23, 2015
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Steffen Wildum, Burkhard Klenke, Astrid Wendt
  • CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF
    Publication number: 20150105388
    Abstract: This invention relates to new carboxamide-substituted heteroaryl-pyrazoles, method for their production, their use for the treatment and/or prophylaxis of diseases, as well as their use for the production of pharmaceutical agents for the treatment and/or prophylaxis of diseases, in particular retroviral diseases, in humans and/or animals.
    Type: Application
    Filed: November 29, 2012
    Publication date: April 16, 2015
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Steffen Wildum, Burkhard Klenke, Astrid Wendt
  • AMIDINE SUBSTITUTED BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS
    Publication number: 20150045340
    Abstract: The present invention relates to novel ?-lactam compounds, their preparation and use. In particular, this invention relates to novel ?-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.
    Type: Application
    Filed: January 23, 2013
    Publication date: February 12, 2015
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Burkhard Klenke, Irith Wiegand, Guido Schiffer, Heike Broetz-Oesterhelt, Samarendra N. Maiti, Jehangir Khan, Andhe Reddy, Zhixiang Yang, Mostafa Hena, Guofeng Jia, Ou Ligong, Hong Liang, Judy Yip, Chuanjun Gao, Sabiha Tajammul, Rahim Mohammad, Ganguli Biswajeet
  • Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase
    Publication number: 20080255134
    Abstract: The present invention provides compounds of formula (I) possessing inhibitory activity against ? adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.
    Type: Application
    Filed: November 8, 2005
    Publication date: October 16, 2008
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Malcolm George Taylor, Burkhard Klenke, Peter D. Suzdak, Reza Mazhari
  • Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure
    Publication number: 20080090827
    Abstract: This invention provides compounds that possess inhibitory activity against ?-adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3). This invention further provides pharmaceutical compositions comprising such compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against ?-adrenergic receptors and PDE.
    Type: Application
    Filed: November 8, 2005
    Publication date: April 17, 2008
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Malcolm Taylor, Burkhard Klenke, Peter Suzdak, Reza Mazhari