Abstract: The invention provides a bifurcated endoluminal prosthetic assembly. The assembly includes a trunk body including a body lumen and at least one access port. At least one branch body is positioned adjacent the access port. The branch body includes a branch lumen in communication with the body lumen. The assembly further includes a ring including at least one connector operably attached to the branch body. The ring is sized to operably engage the trunk body. The ring retains the branch body adjacent the access port. The invention further provides a method of retaining a branch body adjacent a bifurcated endoluminal prosthetic assembly. A ring operably attached to the branch body is compressed. The ring is positioned within the endoluminal prosthetic assembly. The compressed ring is expanded into operable engagement with the endoluminal prosthetic assembly.

Abstract: The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and method of use.

Abstract: The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.

Abstract: Techniques for assessing a physiological profile of a patient include advancing a catheter shaft of a bifurcated renal catheter system into an aorta of the patient, deploying branches of the bifurcated renal catheter system into the renal arteries of the patient, detecting a renal arterial physiological parameter with a sensing mechanism, and assessing the physiological profile of the patient based on the physiological parameter. Related techniques include modifying or initiating pharmacological or surgical treatments for the patient based on the assessment.

Abstract: A method of deploying a prosthesis includes engaging a hub assembly of a handle to a threaded outer surface of a slide shaft of the handle; rotating the hub assembly to cause axial translation of the hub assembly and a sheath coupled to the hub assembly to initiate deployment of the prosthesis; disengaging the hub assembly from the threaded outer surface by pivoting a thread tooth of the hub assembly out of threaded engagement with the threaded outer surface; and sliding the hub assembly on the slide shaft to further retract the sheath and complete deployment of the prosthesis.

Abstract: A method of deploying a prosthesis includes engaging a hub assembly of a handle to a threaded outer surface of a slide shaft of the handle; rotating the hub assembly to cause axial translation of the hub assembly and a sheath coupled to the hub assembly to initiate deployment of the prosthesis; disengaging the hub assembly from the threaded outer surface by pivoting a thread tooth of the hub assembly out of threaded engagement with the threaded outer surface; and sliding the hub assembly on the slide shaft to further retract the sheath and complete deployment of the prosthesis.

Abstract: A delivery system includes a sheath and a handle. The handle includes: a slide shaft having a threaded outer surface; and a hub assembly coupled to the sheath. The hub assembly includes: an inner slider having a thread tooth pivot support; a thread tooth pivotably mounted to the thread tooth pivot support; and a sleeve having a thread tooth press member pressing on the thread tooth, where motion of the sleeve relative to the inner slider pivots the thread tooth on the thread tooth pivot support to engage and disengage the hub assembly with the threaded outer surface.

Abstract: A method of deploying a prosthesis includes restraining the prosthesis within a distal end of a sheath. A slide ring of a handle is rotated to initiate retraction of the sheath. In this manner, the prosthesis is initially very gradually released. The slide ring is then slid to complete retraction of the sheath and to deploy the prosthesis. In this manner, the sheath is easily and quickly retracted thus rapidly completing deployment of the prosthesis. Rapid deployment of the prosthesis facilitates faster procedure times, thus minimizing the period of time during which blood flow is occluded.

Abstract: A method of deploying a prosthesis includes engaging a hub assembly of a handle to a threaded outer surface of a slide shaft of the handle; rotating the hub assembly to cause axial translation of the hub assembly and a sheath coupled to the hub assembly to initiate deployment of the prosthesis; disengaging the hub assembly from the threaded outer surface by pivoting a thread tooth of the hub assembly out of threaded engagement with the threaded outer surface; and sliding the hub assembly on the slide shaft to further retract the sheath and complete deployment of the prosthesis.

Abstract: The invention provides a bifurcated endoluminal prosthetic assembly. The assembly includes a trunk body including a body lumen and at least one access port. At least one branch body is positioned adjacent the access port. The branch body includes a branch lumen in communication with the body lumen. The assembly further includes a ring including at least one connector operably attached to the branch body. The ring is sized to operably engage the trunk body. The ring retains the branch body adjacent the access port. The invention further provides a method of retaining a branch body adjacent a bifurcated endoluminal prosthetic assembly. A ring operably attached to the branch body is compressed. The ring is positioned within the endoluminal prosthetic assembly. The compressed ring is expanded into operable engagement with the endoluminal prosthetic assembly.

Abstract: A method of deploying a prosthesis includes restraining the prosthesis within a proximal end of a sheath. A slide ring of a handle is rotated to initiate retraction of the sheath. In this manner, the prosthesis is initially very gradually released. The slide ring is then slid to complete retraction of the sheath and to deploy the prosthesis. In this manner, the sheath is easily and quickly retracted thus rapidly completing deployment of the prosthesis. Rapid deployment of the prosthesis facilitates faster procedure times, thus minimizing the period of time during which blood flow is occluded.