Patents by Inventor Byoung-Hyun Min

Byoung-Hyun Min has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220160928
    Abstract: The present invention relates to a tissue fusion composition having tissue adhesion and differentiation characteristics, and a preparation method therefor. In the present invention, a tissue fusion composition in the form of a gel or sheet is prepared using stem cells and stem cell-derived extracellular matrix, and it has been confirmed that the composition adheres and binds superbly to biological tissues and can be differentiated into cartilage, bone, cornea, growth plate, and the like, and thus the composition can be used as an adhesive and a differentiation agent in regenerative therapy of damaged tissues or organs, therefore being ultimately and effectively usable as an agent for tissue fusion.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 26, 2022
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventor: Byoung-Hyun MIN
  • Patent number: 11000383
    Abstract: Disclosed is a device for supporting hoop stress applied to a meniscus and preventing deviation of the meniscus, and the device for supporting hoop stress applied to a meniscus and preventing deviation of the meniscus may include an intermediate support member, one side extension member, and the other side extension member.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 11, 2021
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Byoung Hyun Min, Young Jick Kim, Xiang Yun Yin, Do Young Park
  • Publication number: 20190290443
    Abstract: Disclosed is a device for supporting hoop stress applied to a meniscus and preventing deviation of the meniscus, and the device for supporting hoop stress applied to a meniscus and preventing deviation of the meniscus may include an intermediate support member, one side extension member, and the other side extension member.
    Type: Application
    Filed: April 5, 2019
    Publication date: September 26, 2019
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Byoung Hyun MIN, Young Jick KIM, Xiang Yun YIN, Do Young PARK
  • Publication number: 20190184061
    Abstract: The present invention provides a cartilage regenerating composition including a fetal cartilage tissue-derived cell and an extracellular matrix derived from a fetal cartilage tissue, and a preparing method thereof. According to the present invention, the cartilage-regenerating composition may produce a three-dimensional tissue of a size suitable for use as a cartilage without a scaffold, may be easily transplantable regardless of the size and shape of the cartilage defect at the site of administration since it can be administered in the form of a gel, but has high application and adhesion, may exhibit a high binding ability to the host tissue, and may have a phenotype of mature cartilage tissue, thereby exhibiting an excellent cartilage regeneration effect.
    Type: Application
    Filed: August 2, 2017
    Publication date: June 20, 2019
    Inventors: Byoung-Hyun MIN, So Ra PARK, Byung Hyune CHOI, Young Jick KIM, Hyun Ju OH
  • Publication number: 20190070336
    Abstract: The present invention relates to a method for preparing a biocompatible porcine cartilage-derived extracellular matrix membrane capable of adjusting an in-vovo degradation rate and a mechanical property, and a composition containing the porcine cartilage-derived extracellular matrix as an active ingredient, for preventing adhesion between tissues and/or organs. Despite its high biocompatibility as a natural material, cartilage tissue extracellular matrix has a short decomposition period and its mechanical property is weak, thereby restricting the application. Accordingly, a method of enhancing the mechanical property through physical or chemical treatment and radiation treatment has been developed. In the present invention, biomaterials of various formulations were produced by treating the porcine cartilage-derived extracellular matrix with physiochemical methods.
    Type: Application
    Filed: March 9, 2017
    Publication date: March 7, 2019
    Inventors: Byoung-Hyun MIN, Young Jick KIM, Bo Ram SONG, Hee Woong YUN, Sung In JEONG, Youn-Mook LIM, Jong-Seok PARK, Hui-Jeong GWON
  • Publication number: 20110195107
    Abstract: The present invention provides a method for manufacturing a porous three-dimensional scaffold using animal tissue powder, comprising powdering an animal-derived tissue, decellularizing the animal-derived tissue before or after powdering it, or simultaneously with powdering it, and forming the decellularized animal-derived tissue powder into a porous three-dimensional scaffold by a particle leaching method.
    Type: Application
    Filed: October 12, 2009
    Publication date: August 11, 2011
    Applicant: AJOU UNIVERSIYT INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Byoung-Hyun Min, Ji Wook Jang
  • Publication number: 20100255065
    Abstract: The present invention relates to a method for differentiating mesenchymal stem cells and culturing chondrocytes using a fibrin/HA(hyaluronate) composite whose biocompatibility and durability are enhanced, and a therapeutic composition containing the fibrin/HA composite, and more particularly, to a method for culturing chondrocytes and differentiating mesenchymal stem cells into chondrocytes using an alginate-coated fibrin/HA composite gel and a composition for treating a cartilage disease and a composition for treating a disc disease using a fibrin/HA composite scaffold containing a fibrin degradation inhibitor. According to the present invention, disadvantages of the traditional fibrin/HA composite being reduced in size and easily degraded in a short time period during culture were overcome, so that cells can be cultured in a more stable environment.
    Type: Application
    Filed: August 1, 2007
    Publication date: October 7, 2010
    Applicant: REGENPRIME CO., LTD.
    Inventors: Byoung-Hyun Min, So Ra Park, Sang-Hyug Park
  • Publication number: 20100204618
    Abstract: The present invention relates to an ultrasound equipment for treating edema, and more particularly, to an ultrasound equipment to relieve symptoms of edema or repair cellular and tissue edemas by generating 20˜400 mW/cm2 of low intensity ultrasound and use thereof. The ultrasound equipment according to the present invention comprises a main control unit equipped with a control unit for ultrasound generation for generating a 20˜400 mW/cm2 of low intensity ultrasound, an ultrasound generator for generating ultrasound according to the operating state of the main control unit, an ultrasound vibrator vibrating according to the value of ultrasound data inputted from the ultrasound generator, and a probe for delivering ultrasound energy to a treatment site, and when the ultrasound equipment is used, it is possible to treat edema by increasing permeability in blood vessels.
    Type: Application
    Filed: July 30, 2007
    Publication date: August 12, 2010
    Applicant: REGENPRIME CO., LTD.
    Inventors: Byoung-Hyun Min, So Ra Park, Soon Keun Kwon
  • Publication number: 20100136645
    Abstract: The present invention relates to a method for fabricating a cell-derived extracellular matrix scaffold, more particularly, to a method for fabricating a cell-derived extracellular matrix scaffold, the method comprising the steps of obtaining a chondrocyte/extracellular matrix (ECM) membrane from chondrocytes derived from animal cartilage, obtaining a pellet-type scaffold-free construct by culturing after centrifuging the obtained chondrocytes/extracellular matrix (ECM) membrane and freeze-drying the obtained pellet-type construct. The cell-derived ECM scaffold according to the invention is a porous scaffold fabricated using cartilage tissue engineered by culturing chondrocytes in an in vitro scaffold-free system, which is not reduced in size during the cultivation and thus useful for cartilage regeneration.
    Type: Application
    Filed: April 17, 2007
    Publication date: June 3, 2010
    Inventors: Byoung-Hyun Min, So Ra Park, Cheng Zhe Jin, Kwideok Park
  • Publication number: 20100137203
    Abstract: The present invention relates to a method for preparing a cell-derived extracellular matrix membrane, more particularly, to a method for preparing a chondrocyte-derived ECM membrane, the method comprising the steps of forming a suitable thickness of ECM membrane by culturing chondrocytes derived from animal cartilage at a high concentration in vitro, and drying it after decellularization process. The cell-derived ECM membrane scaffold according to the present invention is composed of extracellular matrix secreted by chondrocytes so that the membrane has excellent biocompatibility as well as an immune-previlage effect specific to cartilage. Since the membrane also has a suitable compressive strength, it can be used to replace periosteum for cartilage regeneration or artificial collagen membrane and used as dura mater transplant material, a natural ECM membrane for treating skin loss, materials for cell transplantation and a growth factor delivery vehicle.
    Type: Application
    Filed: April 25, 2007
    Publication date: June 3, 2010
    Applicant: REGENPRIME CO., LTD.
    Inventors: Byoung-Hyun Min, So Ra Park, Byung Hyune Choi
  • Publication number: 20100119577
    Abstract: The present invention relates to a method for preparing a cell-derived ECM scaffold to which chondrocytes or stem cells are attached, a method for cartilage regeneration by tissue engineering, which comprises using the cell-derived ECM scaffold, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold as an effective component. More specifically, the present invention relates to a method for cartilage regeneration by tissue engineering, which comprises transplanting ECM scaffold, having chondrocytes or stem cells attached thereto, into cartilage defects, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold, having chondrocytes or stem cells attached thereto, as an effective component.
    Type: Application
    Filed: May 6, 2007
    Publication date: May 13, 2010
    Inventors: Byoung-Hyun Min, So Ra Park, Cheng Zhe Jin, Byung Hyune Choi
  • Publication number: 20090005710
    Abstract: The present invention relates to an ultrasonic device for the treatment of arthritis, and more particularly, to an ultrasonic device for the treatment or prevention of degenerative arthritis, which is so structured that it generates ultrasonic waves with an intensity of 200-800 mW/cm2 and applies low-intensity ultrasonic energy of 100-400 mW/cm2 to cartilage cells deep in the skin's dermis. The inventive ultrasonic device comprises: a main control unit including an ultrasonic oscillation control unit allowing the generation of ultrasonic waves with a frequency of 0.1-5 MHz and low intensity of 200-800 mW/cm2; an ultrasonic generator for generating ultrasonic waves according to the control state of the main control unit; an ultrasonic vibrator that vibrates according to ultrasonic waves inputted from the ultrasonic generator; and a probe for transferring ultrasonic vibration to a joint to be treated.
    Type: Application
    Filed: September 30, 2005
    Publication date: January 1, 2009
    Applicant: DUPLOGEN, INC.
    Inventors: Byoung-Hyun Min, Sc-Ra Park
  • Patent number: 6558949
    Abstract: This invention relates to media for culturing human cells that the proliferation speed of human cells is increased and the cell expression type is stably manifested, and to a method for culturing human cells using the same. This invention is characterized in that the media used for culturing human cells comprises human serum.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: May 6, 2003
    Inventors: Byoung-Hyun Min, So Ra Park
  • Publication number: 20010005590
    Abstract: This invention relates to media for culturing human cells that the proliferation speed of human cells is increased and the cell expression type is stably manifested, and to a method for culturing human cells using the same. This invention is characterized in that the media used for culturing human cells comprises human serum.
    Type: Application
    Filed: December 13, 2000
    Publication date: June 28, 2001
    Inventors: Byoung-Hyun Min, So Ra Park