Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

Abstract: A cylinder block assembly may include a cylinder block, a cylinder body disposed in the cylinder block, with a plurality of cylinder bores formed in the cylinder body, a fluid jacket, which is formed between an inner circumferential surface of the cylinder block and an outer circumferential surface of the cylinder body, and through which coolant flows, and a block insert disposed in the water jacket and configured to guide a flow of coolant, wherein the cylinder block may include a second block coolant outlet, which is formed at a second side in a surface of an exhaust side of the cylinder block, and through which the coolant in the water jacket is discharged, and wherein the exhaust side may include a side at which combustion gas is exhausted out of the cylinder body.

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

Abstract: A cylinder block includes: a plurality of cylinders; a water jacket through which a coolant flows along an outer periphery of the plurality of cylinders; and insertion members which are inserted into the water jacket formed at both sides of the plurality of cylinders in order to separately cool upper and lower portions of the plurality of cylinders, in which the insertion members restrict a flow of the coolant at a lower side of the water jacket and generate a flow of the coolant at an upper side of the water jacket.

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

Abstract: A cylinder block assembly may include a cylinder block, a cylinder body disposed in the cylinder block, with a plurality of cylinder bores formed in the cylinder body, a fluid jacket, which is formed between an inner circumferential surface of the cylinder block and an outer circumferential surface of the cylinder body, and through which coolant flows, and a block insert disposed in the water jacket and configured to guide a flow of coolant, wherein the cylinder block may include a second block coolant outlet, which is formed at a second side in a surface of an exhaust side of the cylinder block, and through which the coolant in the water jacket is discharged, and wherein the exhaust side may include a side at which combustion gas is exhausted out of the cylinder body.

Abstract: A cylinder block assembly may include a cylinder block, a cylinder body disposed in the cylinder block, with a plurality of cylinder bores formed in the cylinder body, a fluid jacket, which is formed between an inner circumferential surface of the cylinder block and an outer circumferential surface of the cylinder body, and through which coolant flows, and a block insert disposed in the water jacket and configured to guide a flow of coolant, wherein the cylinder block may include a second block coolant outlet, which is formed at a second side in a surface of an exhaust side of the cylinder block, and through which the coolant in the water jacket is discharged, and wherein the exhaust side may include a side at which combustion gas is exhausted out of the cylinder body.

Abstract: A water jacket for a cylinder head includes: an upper body disposed at an upper part of the cylinder head inside the cylinder head and through which a coolant flows; a lower body disposed under the upper body inside the cylinder head and through which the coolant flows; and a connector disposed corresponding to a position of an exhaust valve between the upper body and the lower body and integrally connected to the upper body and the lower body. Tt least one penetration hole is formed in the connector along a length direction.

Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: A cylinder block includes: a plurality of cylinders; a water jacket through which a coolant flows along an outer periphery of the plurality of cylinders; and insertion members which are inserted into the water jacket formed at both sides of the plurality of cylinders in order to separately cool upper and lower portions of the plurality of cylinders, in which the insertion members restrict a flow of the coolant at a lower side of the water jacket and generate a flow of the coolant at an upper side of the water jacket.

Abstract: A water jacket for a cylinder head includes: an upper body disposed at an upper part of the cylinder head inside the cylinder head and through which a coolant flows; a lower body disposed under the upper body inside the cylinder head and through which the coolant flows; and a connector disposed corresponding to a position of an exhaust valve between the upper body and the lower body and integrally connected to the upper body and the lower body. Tt least one penetration hole is formed in the connector along a length direction.

Abstract: A water-jacket structure of a cylinder head may include a plurality of intake side inlet passages installed at intake sides of the cylinder head, respectively, along a length direction of the cylinder head to introduce cooling water supplied from the water-jacket of a cylinder block into the water-jacket of the cylinder head, a combustion chamber cooling passage cooling a combustion chamber using the cooling water supplied from the intake side inlet passage, a plurality of exhaust side outlet passage disposed at exhaust sides of the cylinder head, respectively, along a the length direction of the cylinder head to discharge the cooling water passing through the combustion chamber cooling passage, and an exhaust side gallery communicating with the exhaust side outlet passage to gather the cooling water discharged from the exhaust side outlet passage.

Abstract: A cylinder block assembly may include a cylinder block, a cylinder body disposed in the cylinder block, with a plurality of cylinder bores formed in the cylinder body, a fluid jacket, which is formed between an inner circumferential surface of the cylinder block and an outer circumferential surface of the cylinder body, and through which coolant flows, and a block insert disposed in the water jacket and configured to guide a flow of coolant, wherein the cylinder block may include a second block coolant outlet, which is formed at a second side in a surface of an exhaust side of the cylinder block, and through which the coolant in the water jacket is discharged, and wherein the exhaust side may include a side at which combustion gas is exhausted out of the cylinder body.

Abstract: A water-jacket structure of a cylinder head may include a plurality of intake side inlet passages installed at intake sides of the cylinder head, respectively, along a length direction of the cylinder head to introduce cooling water supplied from the water-jacket of a cylinder block into the water-jacket of the cylinder head, a combustion chamber cooling passage cooling a combustion chamber using the cooling water supplied from the intake side inlet passage, a plurality of exhaust side outlet passage disposed at exhaust sides of the cylinder head, respectively, along a the length direction of the cylinder head to discharge the cooling water passing through the combustion chamber cooling passage, and an exhaust side gallery communicating with the exhaust side outlet passage to gather the cooling water discharged from the exhaust side outlet passage.

Abstract: Disclosed is an exhaust reflux type cleaning robot. In the cleaning robot, foreign substances along with air are sucked into a suction unit by a suction motor, and the foreign substances are collected in a dust collecting unit while the air from which the foreign substances have been removed is discharged to the outside via the suction motor. The cleaning robot includes an exhaust reflux unit which has the suction motor and is provided with left and right air passages disposed on opposite sides of the suction motor, a discharge nozzle unit which is connected to the left and right air passages, a suction unit which is configured such that the discharge nozzle unit is disposed in front of the suction unit, and a sterilization anion generating unit which generates sterilization anions to sterilize air discharged via the suction motor.

Abstract: Disclosed is an exhaust air feedback robot cleaner equipped with a disinfectant anion generator, including a suction motor to intake not only air but also dust from a to-be-cleaned surface through a suction unit installed at the bottom surface and a dust collector to trap dust so as to allow dust-free air to be discharged via the suction motor. In the robot cleaner, the disinfectant anion generator emits disinfectant anions to disinfect the air having been discharged via the suction motor, a spray nozzle installed at the front end of an intake port of the robot cleaner sprays the disinfected air toward the cleaning surface through an exhaust air feedback unit so that the dust on the to-be-cleaned surface may be scattered and disinfected, and finally the air, together with the dust, is sucked in by the suction motor and circulated again to the exhaust air feedback unit.