Patents by Inventor Camilla Kao

Camilla Kao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to prepare macrolide analogs
    Publication number: 20080003648
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.
    Type: Application
    Filed: December 10, 2003
    Publication date: January 3, 2008
    Inventors: Chaitan Khosla, Camilla Kao
  • Recombinant production of novel polyketides
    Publication number: 20060127986
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Application
    Filed: September 15, 2005
    Publication date: June 15, 2006
    Inventors: Chaitan Khosla, David Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Macrolide analogs
    Publication number: 20060019371
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Application
    Filed: January 14, 2005
    Publication date: January 26, 2006
    Inventors: Chaitan Khosla, Gary Ashley, Camilla Kao, Robert McDaniel
  • Macrolide analogs
    Patent number: 6984515
    Abstract: A polyketide or glycosylated polyketide which has the formula: wherein R* is methyl or ethyl; each of R1-R6 is methyl; X1 is OH or H; and/or X2 is=O, OH or H; X3 is OH or H; X4 is OH or H; a pi bond is present at positions 10-11, 8-9, 4-5 and/or 2-3; and wherein at least one of the following characteristics is present: X1 is H; X2 is OH or H; X3 is H; X4 is H; or a pi bond is present at positions 10-11, 8-9, 4-5 and/or 2-3.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: January 10, 2006
    Assignees: The LeLand Stanford Junior University, Kosan Biosciences, Inc.
    Inventors: Chaitan Khosla, Gary Ashley, Camilla Kao, Robert McDaniel
  • Methods to prepare cells comprising heterologous polyketide synthase expression systems
    Patent number: 6969611
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: November 29, 2005
    Assignees: The Board of Trustees of the Leland Stanford University, The John Innes Institute
    Inventors: Chaitan Khosla, David A. Hopwood, Suzanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Modular polyketide synthases with altered activity
    Publication number: 20050032176
    Abstract: The substrate specificity of modular polyketide synthases is altered by mutating or replacing acyltransferase regions thereof.
    Type: Application
    Filed: May 19, 2004
    Publication date: February 10, 2005
    Inventors: Chaitan Khosla, Gary Ashley, Hong Fu, Camilla Kao, Robert McDaniel
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20040209322
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.
    Type: Application
    Filed: December 3, 2003
    Publication date: October 21, 2004
    Inventors: Chaitan Khosla, Camilla Kao
  • Method to produce novel polyketides
    Patent number: 6710189
    Abstract: A polyketide, or an antibiotic which is obtainable from the polyketide by a method comprising treating the polyketide with a culture medium conditioned by Saccharopolyspora erythraea, selected from the group consisting of:
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: March 23, 2004
    Assignees: Stanford University, Brown University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao, Gary Ashley
  • Method to produce novel polyketides
    Publication number: 20030044938
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Application
    Filed: June 28, 2002
    Publication date: March 6, 2003
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao, Gary Ashley
  • Method to produce novel polyketides
    Patent number: 6500960
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula wherein A is a moiety that activates the diketide, and at least one of R1 and R2 is a substituent other than that natively occurring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: December 31, 2002
    Assignees: Stanford University (Board of Trustees of the Leland Stanford Junior University), Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Recombinant production of novel polyketides
    Patent number: 6461838
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: October 8, 2002
    Assignees: The Leland Stanford Junior University, The John Innes Institute
    Inventors: Chaitan Khosla, David A. Hopwood, Suzanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Recombinant production of novel polyketides
    Publication number: 20020110874
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Application
    Filed: August 8, 2001
    Publication date: August 15, 2002
    Inventors: Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Recombinant production of novel polyketides
    Patent number: 6399382
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: June 4, 2002
    Assignees: The Leland Stanford Junior University, The John Innes Centre
    Inventors: Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Camilla Kao
  • Recombinant production of novel
    Publication number: 20010039021
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Application
    Filed: January 5, 2001
    Publication date: November 8, 2001
    Inventors: Chaitan Khosla, David A. Hopwood, Suzanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Method to produce novel polyketides
    Publication number: 20010024811
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Application
    Filed: May 29, 2001
    Publication date: September 27, 2001
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Crane, Camilla Kao
  • Cell-free synthesis of polyketides
    Patent number: 6274560
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: August 14, 2001
    Assignees: Brown University Research Foundation, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Method to produce novel polyketides
    Patent number: 6261816
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: July 17, 2001
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Recombinant production of novel polyketides
    Patent number: 6077696
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: June 20, 2000
    Assignees: The Johns Innes Institute, The Leland Stanford Junior University
    Inventors: Chaitan Khosla, David A. Hopwood, Suzanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Method to produce novel polyketides
    Patent number: 6066721
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: May 23, 2000
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Recombinant production of novel polyketides
    Patent number: 5962290
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: October 5, 1999
    Assignees: The Leland Stanford Junior University, The John Innes Centre
    Inventors: Chaitan Khosla, David A. Hopwood, Suzanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao