Patents by Inventor Carl Alving

Carl Alving has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220160855
    Abstract: The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 26, 2022
    Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Sheetij Dutta, Zoltan Beck, Carl Alving, Gary Matyas
  • Patent number: 10081658
    Abstract: The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: September 25, 2018
    Assignees: Advanced BioScience Laboratories, Inc., The United States of America as Represented by the Secretary of the Army, The Henry M. Jackson Foundation for the Advancement of Military Medicines, Inc.
    Inventors: Vaniambadi Kalyanaraman, Stephen Whitney, Thomas C. VanCott, Victoria Polonis, Carl Alving, Gary R. Matyas, Mangala Rao, Mary Marovich, Francine McCutchan, Sodsai Tovanabutra, Eric Sanders-Buell
  • Publication number: 20140220107
    Abstract: The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 7, 2014
    Applicants: ADVANCED BIOSCIENCE LABORATORIES, INC., HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, THE GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY
    Inventors: Vaniambadi Kalyanaraman, Stephen Whitney, Thomas C. Vancott, Victoria Polonis, Carl Alving, Gary R. Matyas, Mangala Rao, Mary Marovich, Francine McCutchan, Sodsai Tovanabutra, Eric Sanders-Buell
  • Publication number: 20080233142
    Abstract: A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a systemic or mucosol antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement.
    Type: Application
    Filed: May 24, 2007
    Publication date: September 25, 2008
    Inventors: Gregory M. Glenn, Carl Alving
  • Publication number: 20080107724
    Abstract: A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents or emulsifier which contain amphiphilic molecules such as polyethoxylated oils or a derivative thereof, or (b) caused by a drug in a vehicle containing amphiphilic molecules such as phopholipids or derivative thereof, emplying a complement inhibitor. Drug compositions containing amphiphilic molecules, or derivatives thereof and a complement inhibitor, and pharmaceutical compositions including a drug, solvent or carrier containing amphiphilic molecules or derivatives thereof, and a complement inhibitor are also provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Inventors: Janos Szebeni, Carl Alving
  • Publication number: 20070072225
    Abstract: Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars and carbohydrates. Monoclonal antibodies and a method of making monoclonal antibodies of the invention include monoclonal antibodies that are broadly neutralizing to HIV-1 or other envelop viruses wherein the monoclonal antibody has subsites that simultaneously recognize protein and lipid epitopes from the virus.
    Type: Application
    Filed: September 22, 2006
    Publication date: March 29, 2007
    Inventor: Carl Alving
  • Publication number: 20060269593
    Abstract: A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a formulation containing antigen and adjuvant to intact skin of the animal or human. The efficiency of immunization may be enhanced by adding hydrating agents (e.g., liposomes), penetration enhancers, or occlusive dressings to the transcutaneous delivery system. This system may allow activation of Langerhans cells in the skin, migration of the Langerhans cells to lymph nodes, and antigen presentation.
    Type: Application
    Filed: January 19, 2006
    Publication date: November 30, 2006
    Inventors: Gregory Glenn, Carl Alving
  • Publication number: 20060160160
    Abstract: The invention is a method and assay for detecting human squalene antibodies in sera or plasma using a blocking agent of ?0.5% casein in a phosphate buffered saline (PBS) solution.
    Type: Application
    Filed: January 7, 2005
    Publication date: July 20, 2006
    Inventors: Carl Alving, Gary Matyas, Nabila Wassef, Mangala Rao
  • Publication number: 20060002949
    Abstract: Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response without the use of a heterologous adjuvant. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigens. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced.
    Type: Application
    Filed: June 1, 2005
    Publication date: January 5, 2006
    Inventors: Gregory Glenn, Carl Alving
  • Publication number: 20060002959
    Abstract: Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response. Use of skin-active adjuvants is preferred. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigen and adjuvant. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof.
    Type: Application
    Filed: April 20, 2005
    Publication date: January 5, 2006
    Inventors: Gregory Glenn, Carl Alving
  • Publication number: 20050281789
    Abstract: The invention relates to transcutaneous and/or transdermal transport of materials, such as antigens, drugs, drugs, nucleic acids, (e.g., DNA and RNA), proteins, other therapeutic agents, dyes, and the like, into the skin and/or the body. The material is transported transcutaneously and/or transdermally using an antigen presenting cell (APC) by applying the APC and the material on to the surface of the skin.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 22, 2005
    Inventors: Mangala Rao, Carl Alving, Kristina Peachman, Stephen Rothwell