Patents by Inventor Carl Genberg

Carl Genberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150374719
    Abstract: Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 31, 2015
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Chad S. Beus, Paul B. Savage
  • Publication number: 20150374720
    Abstract: Disclosed are methods for increasing the rate of healing of a tissue wound by administering a composition including a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting wound healing in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of a tissue wound. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: September 9, 2015
    Publication date: December 31, 2015
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Paul B. Savage
  • Publication number: 20150366880
    Abstract: Disclosed herein are methods of promoting osteogenesis in a subject, comprising administering a composition comprising a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting osteogenesis in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of bone disease or the treatment of broken bones. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: September 1, 2015
    Publication date: December 24, 2015
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Paul B. Savage
  • Patent number: 9161942
    Abstract: Disclosed are methods for increasing the rate of healing of a tissue wound by administering a composition including a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting wound healing in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of a tissue wound. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: October 20, 2015
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Paul B. Savage
  • Patent number: 9155746
    Abstract: Disclosed herein are methods of promoting osteogenesis in a subject, comprising administering a composition comprising a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting osteogenesis in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of bone disease or the treatment of broken bones. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: October 13, 2015
    Assignee: Brigham Young University
    Inventors: Carl Genberg, Paul B. Savage
  • Publication number: 20150258123
    Abstract: Cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making and using the same. Particularly advantageous uses include treating infections in patient and sub-patient populations, especially those having a bone disease, a broken bone, a bone infection, or a bone implant.
    Type: Application
    Filed: March 11, 2015
    Publication date: September 17, 2015
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Paul B. Savage, Carl Genberg
  • Publication number: 20150110767
    Abstract: Methods of treating, reducing, or preventing lung infections or lung inflammation include identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 23, 2015
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: PAUL B. SAVAGE, CARL A. GENBERG, MICHAEL D. TRIPLETT
  • Publication number: 20150093423
    Abstract: Particulate ceragenin materials may be manufactured by (i) providing a ceragenin feed material comprised of ceragenin molecules, each having a sterol backbone and a plurality cationic groups attached thereto; (ii) fracturing the ceragenin feed material in a milling apparatus to produce a ceragenin particulate material having a particle size distribution with a median particle size in a range from 5 nm to 20 ?m; and (iii) during fracturing, maintaining the ceragenin feed with a moisture content of less than or equal to 10% by weight.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 2, 2015
    Applicant: Brigham Young University
    Inventors: Paul B. Savage, Carl Genberg
  • Patent number: 8932614
    Abstract: A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: January 13, 2015
    Inventors: Paul B. Savage, Carl Genberg
  • Publication number: 20140336131
    Abstract: Disclosed herein are methods of treating, reducing, or preventing a disease such as oral mucositis, gastric mucositis, or inflammatory fibrosis, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: July 25, 2014
    Publication date: November 13, 2014
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Paul B. Savage, Carl A. Genberg
  • Publication number: 20140271761
    Abstract: A method and kit for manufacturing a composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
    Type: Application
    Filed: May 27, 2014
    Publication date: September 18, 2014
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: PAUL B. SAVAGE, Carl Genberg
  • Publication number: 20140274913
    Abstract: Compositions and methods for treating, reducing, or preventing a disease or symptom such as gingivitis, periodontitis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, or pain. The method includes identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Brigham Young University
    Inventors: Paul B. Savage, Carl Genberg
  • Publication number: 20140194401
    Abstract: Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: January 7, 2014
    Publication date: July 10, 2014
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Paul B. Savage
  • Publication number: 20130243842
    Abstract: Disclosed herein are methods of promoting osteogenesis in a subject, comprising administering a composition comprising a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting osteogenesis in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of bone disease or the treatment of broken bones. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: September 13, 2012
    Publication date: September 19, 2013
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Paul B. Savage
  • Publication number: 20130243823
    Abstract: Disclosed are methods for increasing the rate of healing of a tissue wound by administering a composition including a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting wound healing in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of a tissue wound. Kits comprising such compositions and instructions on such methods are also contemplated herein.
    Type: Application
    Filed: September 13, 2012
    Publication date: September 19, 2013
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Carl Genberg, Paul B. Savage
  • Publication number: 20130243840
    Abstract: A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
    Type: Application
    Filed: August 24, 2012
    Publication date: September 19, 2013
    Inventors: Paul B. Savage, Carl Genberg