Patents by Inventor Carl P. Schaffner

Carl P. Schaffner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8323672
    Abstract: Compositions and method of using the same for the removal of ticks embedded in the skin or tissue of a human or animal host and for preventing ticks from attaching themselves to and biting humans or other animals.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: December 4, 2012
    Assignee: Karykion Corporation
    Inventors: Carl P. Schaffner, William K. Griesinger
  • Publication number: 20120003333
    Abstract: Compositions and method of using the same for the removal of ticks embedded in the skin or tissue of a human or animal host and for preventing ticks from attaching themselves to and biting humans or other animals.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 5, 2012
    Inventors: Carl P. Schaffner, William K. Griesinger
  • Publication number: 20090270354
    Abstract: Compositions and method of using the same for the removal of ticks embedded in the skin or tissue of a human or animal host and for preventing ticks from attaching themselves to and biting humans or other animals.
    Type: Application
    Filed: July 7, 2009
    Publication date: October 29, 2009
    Applicant: KARYKION INC.
    Inventors: Carl P. Schaffner, William K. Griesinger
  • Patent number: 7604814
    Abstract: Provided are compositions and an article for manufacture with an associated writing comprising the composition for the removal of ticks embedded in the skin or tissues of a human or animal host. Moreover a method is provided for removal of ticks embedded in the skin or tissues of a human or animal host by the topical application of the composition.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: October 20, 2009
    Assignee: Karykion Inc.
    Inventors: Carl P. Schaffner, William K. Griesinger
  • Publication number: 20090208448
    Abstract: Cholesterol-uptake-blocking drugs inhibit angiogenesis and are useful to inhibit diseases perpetuated by angiogenesis. Cholesterol reduction with the use of the drugs increases the intratumoral level of thrombospondin-1, an angiogenesis inhibitor. Ezetimibe (Zetia®), a specific cholesterol-uptake blocking drug, also retards the growth of human tumors, most preferably in combination with low-cholesterol diet. The pharmacologic reduction in serum cholesterol retards prostate cancer growth by inhibiting tumor angiogenesis to combat the growth of prostatic tumors which are directly accelerated by hypercholesterolemia.
    Type: Application
    Filed: February 12, 2009
    Publication date: August 20, 2009
    Inventors: Keith R. Solomon, Kristine Pelton, Carl P. Schaffner, Michael R. Freeman
  • Patent number: 7449453
    Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: November 11, 2008
    Assignees: Karykion Inc., Children's Medical Center Corporation
    Inventors: Carl P. Schaffner, Keith R. Solomon, Michael R. Freeman
  • Publication number: 20080057018
    Abstract: Provided are compositions and an article for manufacture with an associated writing comprising the composition for the removal of ticks embedded in the skin or tissues of a human or animal host. Moreover a method is provided for removal of ticks embedded in the skin or tissues of a human or animal host by the topical application of the composition.
    Type: Application
    Filed: August 29, 2006
    Publication date: March 6, 2008
    Applicant: Karykion, Inc.
    Inventors: Carl P. Schaffner, William K. Griesinger
  • Patent number: 7098198
    Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: August 29, 2006
    Assignee: Karykion, Inc.
    Inventors: Carl P. Schaffner, Keith R. Solomon
  • Patent number: 6933292
    Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: August 23, 2005
    Assignee: Children's Medical Center Corporation
    Inventors: Carl P. Schaffner, Keith R. Solomon, Michael R. Freeman
  • Publication number: 20040116358
    Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.
    Type: Application
    Filed: July 30, 2003
    Publication date: June 17, 2004
    Inventors: Carl P. Schaffner, Keith R. Solomon, Michael R. Freeman
  • Patent number: 6132993
    Abstract: Methods are provided for improving the microbial production of amphotericin B by the selective inhibition of amphotericin A by means of protein synthesis inhibitors.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: October 17, 2000
    Assignee: Rutgers University
    Inventors: Carl P. Schaffner, David J. Kientzler
  • Patent number: 4639420
    Abstract: An immunoassay is provided for cholesterol epoxide. To prepare the antibodies used in the immunoassay, novel immunogens, are prepared which comprise a 3,5(6)-transdiaxial-dihydroxycholestane-6(5)-yl-hapten adduct linked to a covalently bonded bridge to a carrier protein. To detect cholesterol epoxide in the sample, it is converted to the hapten adduct, then contacted with the selected antibody.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: January 27, 1987
    Inventor: Carl P. Schaffner
  • Patent number: 4482540
    Abstract: Orally administered compositions for altering lipid metabolism are described herein, these compositions containing an effective dose of endomycin. Also the method of altering lipid metabolism including reducing and controlling the blood cholesterol level, is described herein.
    Type: Grant
    Filed: June 8, 1981
    Date of Patent: November 13, 1984
    Assignee: Schmid Laboratories
    Inventors: Harry W. Gordon, Carl P. Schaffner
  • Patent number: 4307120
    Abstract: A method of preparing dried coconut meat which retains its white appearance during extended storage while having increased flavor and odor imparting constituents by contacting raw moist coconut with a sulfur dioxide solution followed by microwave electromagnetic irradiation.
    Type: Grant
    Filed: November 26, 1979
    Date of Patent: December 22, 1981
    Inventors: Conrado A. Escudero, Carl P. Schaffner
  • Patent number: 4292310
    Abstract: Orally administered compositions for altering liquid metabolism are described herein, these compositions containing an effective dose of n-acyl amphotericin B. Also the method of altering lipid metabolism including reducing and controlling the blood cholesterol level, is described herein.
    Type: Grant
    Filed: April 12, 1979
    Date of Patent: September 29, 1981
    Inventors: Harry W. Gordon, Carl P. Schaffner
  • Patent number: 4163050
    Abstract: Orally administered compositions for altering lipid metabolism are described herein, these compositions containing an effective dose of candimycin. Also the method of altering lipid metabolism including reducing and controlling the blood cholesterol level, is described herein.
    Type: Grant
    Filed: May 9, 1977
    Date of Patent: July 31, 1979
    Assignee: Schmid Laboratories, Inc.
    Inventors: Harry W. Gordon, Carl P. Schaffner
  • Patent number: 4067966
    Abstract: Orally administered compositions for altering lipid metabolism are described herein, these compositions containing an effective dose of antibiotic SCH-16656. Also the method of altering lipid metabolism including reducing and controlling the blood cholesterol level is described herein.
    Type: Grant
    Filed: December 5, 1975
    Date of Patent: January 10, 1978
    Assignee: Schmid Laboratories, Inc.
    Inventors: Harry W. Gordon, Carl P. Schaffner
  • Patent number: 4064230
    Abstract: A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin, hamycin and mediocidin is described which comprises orally administering the polyenic macrolide with an absorbent material. Compositions containing a polyenic macrolide and a suitable absorbent material preferably in beadlet form are described for use in treating various conditions including prostate hypertrophy, hypercholesterolemia and acne.
    Type: Grant
    Filed: October 8, 1976
    Date of Patent: December 20, 1977
    Assignee: Schmid Laboratories, Inc.
    Inventors: Harry W. Gordon, Carl P. Schaffner
  • Patent number: 4039659
    Abstract: Orally administered compositions for altering lipid metabolism are described herein, these compositions containing an effective dose of Levorin. Also the method of altering lipid metabolism including reducing and controlling the blood cholesterol level, is described herein.
    Type: Grant
    Filed: November 6, 1974
    Date of Patent: August 2, 1977
    Assignee: Schmid Laboratories, Inc.
    Inventors: Harry W. Gordon, Carl P. Schaffner
  • Patent number: 4035568
    Abstract: Derivatives of amphoteric polyene macrolide antibiotics which carry, on the lactone ring, a carboxyl group and an amino sugar characterized by a primary amine group, consist of (a) the methyl, ethyl or propyl ester formed by esterification of the carboxyl group, and (b) salts of such polyene esters constituted as acid addition salts formed with the amine group. The derivatives (a) and (b) have effective antimicrobial activity, e.g. antifungal potency, comparable to the base antibiotics, and the acid salts (b), produced by suitable acids, e.g. hydrochlorides, can be made to have good water solubility which is normally unattainable with the base compounds and is of special advantage in a compound which retains strong activity. Other addition salts are also of value, for example to provide lipid-soluble forms of these antifungal polyenes.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: July 12, 1977
    Assignee: Rutgers Research and Educational Foundation
    Inventors: Carl P. Schaffner, Witold Mechlinski