Abstract: The present invention provides a method for detecting DNA-activated protein kinase (DNA-PK) activity in a biological sample.

Abstract: The present invention provides methods for generating phosphorylation site-specific immunological reagents. More specifically, a phosphopeptide mimetic is incorporated into a polypeptide in place of a phosphorylated amino acid. The polypeptide is used as antigen by standard methods to generate either monoclonal or polyclonal antibodies which cross-react with the naturally phosphorylated polypeptide. The phosphopeptide mimetic preferably contains a non-hydrolyzable linkage from the appropriate carbon atom of the amino acid residue to a phosphate group. A preferred linkage is a CF2 group. Such a linkage is used to generate the phosphoserine mimetic F2Pab, which is incorporated into a polypeptide sequence derived from p53 to produce antibodies which recognize a specific phosphorylation state of p53. A CF2 group linkage is also used to produce the phosphothreonine mimetic F2Pmb, and to produce the phosphotyrosine mimetic, F2Pmp.

Abstract: This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Abstract: This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Abstract: A radial bleed total thrust control system for a rocket propelled missile. In the preferred embodiment, the apparatus employs at least two pairs of straight radial nozzles which are disposed within and penetrate the skin of the missile and at least two pairs of tangentially canted radial nozzles which are also disposed within and penetrate the skin of the missile to provide control moments necessary to control the pitch, yaw, roll and/or the axial thrust of the missile. In one embodiment the radial and tangential nozzles are supplied by the same source of propelling gas as the main thrust nozzle, and in a second embodiment the straight radial and tangentially canted radial nozzles have a separate gas supply source.

Abstract: A radial bleed total thrust control system for a rocket propelled missile. In the preferred embodiment, the apparatus employs at least two pairs of straight radial nozzles which are disposed within and penetrate the skin of the missile and at least two pairs of tangentially canted radial nozzles which are also disposed within and penetrate the skin of the missile to provide control moments necessary to control the pitch, yaw, roll and/or the axial thrust of the missile. In one embodiment the radial and tangential nozzles are supplied by the same source of propelling gas as the main thrust nozzle, and in a second embodiment the straight radial and tangentially canted radial nozzles have a separate gas supply source.