Patents by Inventor Carlo Giovanni Traverso

Carlo Giovanni Traverso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190209090
    Abstract: Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject.
    Type: Application
    Filed: November 28, 2018
    Publication date: July 11, 2019
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Yong Lin Kong
  • Publication number: 20190175500
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
  • Publication number: 20190160139
    Abstract: Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure.
    Type: Application
    Filed: August 31, 2018
    Publication date: May 30, 2019
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Ameya R. Kirtane, Daniel Cahill, Ganesh Shankar
  • Publication number: 20190133936
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 9, 2019
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
  • Publication number: 20190125667
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: June 21, 2018
    Publication date: May 2, 2019
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Omar Abouzid, Ameya R. Kirtane
  • Publication number: 20190111130
    Abstract: Disclosed herein are compositions comprising a pharmaceutical agent and an ultrasound enhancing agent. The compositions are useful in combination with ultrasound to enhance delivery of a pharmaceutical agent to, for example, tissue of a subject in need thereof. Accordingly, also provided herein are methods involving ultrasound for delivering a pharmaceutical agent to a subject, e.g., a subject that has inflammatory bowel disease or proctitis.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Dan Minahan, Taylor A. Bensel, Thomas von Erlach, Carl Magnus Schoellhammer
  • Publication number: 20190104979
    Abstract: Improvements in ingestible electronics with the capacity to sense physiologic and pathophysiologic states have transformed the standard of care for patients. Yet despite advances in device development, significant risks associated with solid, non-flexible gastrointestinal transiting systems remain. Here, we disclose an ingestible, flexible piezoelectric device that senses mechanical deformation within the gastric cavity. We demonstrate the capabilities of the sensor in both in vitro and ex vivo simulated gastric models, quantified its key behaviors in the GI tract by using computational modeling, and validated its functionality in awake and ambulating swine. Our piezoelectric devices can safely sense mechanical variations and harvest mechanical energy inside the gastrointestinal tract for diagnosing and treating motility disorders and for monitoring ingestion in bariatric applications.
    Type: Application
    Filed: October 5, 2018
    Publication date: April 11, 2019
    Inventors: Canan Dagdeviren, Carlo Giovanni TRAVERSO, Robert S. LANGER
  • Publication number: 20190070108
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: November 1, 2018
    Publication date: March 7, 2019
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
  • Publication number: 20190070107
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: November 1, 2018
    Publication date: March 7, 2019
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
  • Publication number: 20190064153
    Abstract: Tissue explants of the gastrointestinal tract are provided. Methods of making and using the tissue explants are also provided, along with substrates designed for the tissue explants described.
    Type: Application
    Filed: March 23, 2018
    Publication date: February 28, 2019
    Inventors: Carlo Giovanni TRAVERSO, Thomas Christian VON ERLACH, Robert S. LANGER, Sarah SAXTON, Daniel MINAHAN
  • Patent number: 10182985
    Abstract: Certain embodiments comprise administering a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance, and, optionally, a linker. In some such embodiments, the linker may be configured to degrade.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: January 22, 2019
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Jr., Philip A. Eckhoff
  • Patent number: 10149635
    Abstract: Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, the approach disclosed here enables vital sign monitoring internally from the gastrointestinal tract. The large animal (porcine) experiments and a robust processing disclosed herein demonstrate the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: December 11, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Albert Joseph Swiston, Robert S. Langer, Tadd Bernard Hughes, Kerry Johnson, Carlo Giovanni Traverso
  • Publication number: 20180193621
    Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.
    Type: Application
    Filed: June 28, 2016
    Publication date: July 12, 2018
    Inventors: Daniel Bonner, Colin R. Gardner, Thomas H. Jozefiak, Christopher R. Loose, David Lucchino, Andrew Craig Miller, Carlo Giovanni Traverso, Ayush Verma, Arthur J. Coury, Peter Tran, John Jantz
  • Publication number: 20180055991
    Abstract: Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.
    Type: Application
    Filed: October 6, 2017
    Publication date: March 1, 2018
    Inventors: Carl Magnus SCHOELLHAMMER, Carlo Giovanni TRAVERSO, Avraham SCHROEDER, Baris POLAT, Daniel BLANKSCHTEIN, Robert S. LANGER, William BRUGGE
  • Publication number: 20170311894
    Abstract: Aspects disclosed in the detailed description include an ingestible power harvesting device and related applications. An ingestible power harvesting device includes a cathode electrode and an anode electrode that can catalyze a power generating reaction to generate a direct current (DC) power when surrounded by an acidic electrolyte. The cathode electrode and the anode electrode are coupled to an encapsulated electronic device that includes power harvesting circuitry configured to harvest the DC power and output a DC supply voltage for a prolonged period. In examples discussed herein, the prolonged period is at least five days. The DC supply voltage powers an electronic circuit in the encapsulated electronic device to support a defined in vivo operation (e.g., controlled drug delivery, in vivo vital signs monitoring, etc.). As such, the ingestible power harvesting device can operate in vivo for the prolonged period without requiring an embedded conventional battery.
    Type: Application
    Filed: April 26, 2017
    Publication date: November 2, 2017
    Inventors: Phillip Nadeau, Dina El-Damak, Dean Glettig, Yong Lin Kong, Niclas Roxhed, Robert Langer, Anantha P. Chandrakasan, Carlo Giovanni Traverso
  • Publication number: 20170266112
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: December 16, 2016
    Publication date: September 21, 2017
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Omar Abouzid, Ameya R. Kirtane
  • Publication number: 20170266931
    Abstract: Compositions and articles comprising omniphobic materials for bio-related and other applications are generally provided. In some embodiments, the compositions and articles described herein may be introduced internally of a subject (e.g., in the esophagus, in the gastrointestinal tract, in the rectum). In some aspects, the compositions and articles comprise a releasable therapeutic agent In some embodiments, the compositions and articles described herein may be configured to have a relatively short retention time at the location internal of the subject (e.g., less than 2 seconds) such as a capsule comprising an omniphobic coating. In alternative embodiments, the compositions and articles described herein may be configured to have relative long retention times at the location internal of the subject (e.g., greater than 10 minutes) and include a mucoadhesive portion as well as an omniphobic portion. Such articles may have an omniphobic portion which resists adhesion and/or fouling (e.g.
    Type: Application
    Filed: March 21, 2017
    Publication date: September 21, 2017
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Shiyi Zhang, Young-Ah Lucy Lee
  • Publication number: 20170156632
    Abstract: Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, the approach disclosed here enables vital sign monitoring internally from the gastrointestinal tract. The large animal (porcine) experiments and a robust processing disclosed herein demonstrate the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.
    Type: Application
    Filed: August 15, 2016
    Publication date: June 8, 2017
    Inventors: Albert Joseph SWISTON, ROBERT S. LANGER, TADD BERNARD HUGHES, KERRY JOHNSON, CARLO GIOVANNI TRAVERSO
  • Publication number: 20170135954
    Abstract: Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
    Type: Application
    Filed: June 11, 2015
    Publication date: May 18, 2017
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Jiaqi Lin, Angela DiCiccio, Dean Liang Glettig, Lowell L. Wood, JR., Philip A. Eckhoff
  • Publication number: 20170128576
    Abstract: Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
    Type: Application
    Filed: June 11, 2015
    Publication date: May 11, 2017
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Tokitae LLC
    Inventors: Shiyi Zhang, Andrew Bellinger, Carlo Giovanni Traverso, Robert S. Langer, Dean Liang Glettig, Lowell L. Wood, JR., Philip A. Eckhoff