Abstract: A method of fabricating a microchannel device is provided. The method includes determining, based on a plurality of design criteria, a microchannel vascular network design. The microchannel vascular network design includes a first channel network, a second microchannel network based on the first channel network, and a structure for providing fluidic communication through between the first channel network and the second channel network. The method includes receiving, in electronic form, the microchannel vascular network design at a fabrication system. The fabrication system comprises a pre-polymer solution. The method includes forming, based on the microchannel vascular network design, a microchannel vascular network device of a polymer material at the fabrication system using the pre-polymer solution, thereby fabricating the microchannel vascular network device.