Patents by Inventor Carole Berger

Carole Berger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8231868
    Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: July 31, 2012
    Assignee: Yale University
    Inventors: Richard Leslie Edelson, Carole Berger, Michael Girardi
  • Publication number: 20100209409
    Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
    Type: Application
    Filed: May 4, 2010
    Publication date: August 19, 2010
    Inventors: Richard Leslie Edelson, Carole Berger, Michael Girardi
  • Patent number: 7727523
    Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: June 1, 2010
    Assignee: Yale University
    Inventors: Richard Leslie Edelson, Carole Berger, Michael Girardi
  • Publication number: 20070281354
    Abstract: Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by exposing the monocytes to proteins adhered to the surface of a treatment device to induce differentiation of the monocytes in to dendritic cells. Differentiation of the monocytes may also be induced by physical perturbation of the monocytes during treatment. The treated monocytes may be co-incubated with disease effector agents, which may be phagocytized by the immature dendritic cells.
    Type: Application
    Filed: May 16, 2007
    Publication date: December 6, 2007
    Inventors: Richard Edelson, Carole Berger
  • Patent number: 7109031
    Abstract: A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are induced to differentiate into dendritic cells by activation forces resulting from flow of the monocytes through a treatment apparatus having plastic channels. The interior surface of the plastic channel may be modified to increase the available surface area for interaction with blood monocytes. Platelets and serum protein may be removed from the blood prior to treatment to reduce or eliminate contamination of the plastic channel by these blood components. Functional dendritic cells generated from induced monocytes are incubated together with apoptotic or inactivated disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: September 19, 2006
    Assignee: Yale University
    Inventors: Richard Leslie Edelson, Carole Berger, Douglas Hanlon, Michael Girardi
  • Publication number: 20050158856
    Abstract: Methods are provided for producing functional antigen presenting dendritic cells. The dendritic cells are produced by treating an extracorporeal quantity of a subject's blood to induce differentiation of blood monocytes into dendritic cells. The dendritic cells may be exposed to cellular material encapsulated within a biodegradable polymer material to produce the antigen presenting dendritic cells.
    Type: Application
    Filed: July 1, 2004
    Publication date: July 21, 2005
    Inventors: Richard Edelson, Carole Berger, Douglas Hanlon, Hong Shen
  • Publication number: 20050084966
    Abstract: Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by subjecting the monocytes to physical perturbation. The monocytes may be treated, for example, by mechanical or manual shaking in an appropriate container, or the monocytes may be subjected to physical perturbation as they flow through a packed column. The treated monocytes may be co-incubated with disease effector agents, which may be phagocytized by the immature dendritic cells.
    Type: Application
    Filed: July 1, 2004
    Publication date: April 21, 2005
    Inventors: Richard Edelson, Carole Berger
  • Publication number: 20030219420
    Abstract: A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are induced to differentiate into dendritic cells by activation forces resulting from flow of the monocytes through a treatment apparatus having plastic channels. The interior surface of the plastic channel may be modified to increase the available surface area for interaction with blood monocytes. Platelets and serum protein may be removed from the blood prior to treatment to reduce or eliminate contamination of the plastic channel by these blood components. Functional dendritic cells generated from induced monocytes are incubated together with apoptotic or inactivated disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.
    Type: Application
    Filed: March 13, 2003
    Publication date: November 27, 2003
    Inventors: Richard Leslie Edelson, Carole Berger, Douglas Hanlon, Michael Girardi
  • Patent number: 6607722
    Abstract: A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiation in the presence of a photoactivatable agent capable of forming photoadducts with cellular DNA components, and/or treatment with a DNA binding agent. The treated monocytes are then incubated for a period of time sufficient to maximize the number of functional dendritic cells in the treated cell population. Functional dendritic cells generated from induced monocytes are incubated together with disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: August 19, 2003
    Inventors: Richard Leslie Edelson, Carole Berger
  • Publication number: 20030133914
    Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
    Type: Application
    Filed: November 8, 2002
    Publication date: July 17, 2003
    Inventors: Richard Leslie Edelson, Carole Berger, Michael Girardi
  • Patent number: 6524855
    Abstract: A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiation in the presence of a photoactivatable agent capable of forming photoadducts with cellular DNA components, and/or treatment with a DNA binding agent. The treated monocytes are then incubated for a period of time sufficient to maximize the number of functional dendritic cells in the treated cell population. Functional dendritic cells generated from induced monocytes are incubated together with disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: February 25, 2003
    Inventors: Richard Leslie Edelson, Carole Berger
  • Publication number: 20020114793
    Abstract: A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are induced to differentiate into dendritic cells by activation forces resulting from flow of the monocytes through a plastic channel, such as the plastic channel in a conventional photopheresis apparatus. Functional dendritic cells generated from induced monocytes are incubated together with apoptotic or inactivated disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents. Compositions including dendritic cells derived from induced monocytes and compositions including such dendritic cells incubated with disease effector agents are also provided for use in immunotherapeutic treatment.
    Type: Application
    Filed: January 31, 2002
    Publication date: August 22, 2002
    Inventors: Richard Leslie Edelson, Carole Berger, Douglas Hanlon