Patents by Inventor Caroline Kreutzer
Caroline Kreutzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7173105Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.Type: GrantFiled: December 27, 2004Date of Patent: February 6, 2007Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
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Patent number: 7160711Abstract: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.Type: GrantFiled: February 5, 2003Date of Patent: January 9, 2007Assignee: Degussa AGInventors: Brigitte Bathe, Caroline Kreutzer, Bettina Mockel, Georg Thierbach
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Patent number: 7105321Abstract: The invention relates to polynucleotides corresponding to the ccpA2 gene and which encode a CcpA2 catabolite control protein, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having CcpA2 catabolite control activity.Type: GrantFiled: December 2, 2003Date of Patent: September 12, 2006Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer, Thomas Hermann, Mike Farwick, Achim Marx, Walter Pfefferle
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Patent number: 7101690Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is: a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, or b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, or c) polynucleotide which is complementary to the polynucleotides of a) or b), or d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ccpA1 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.Type: GrantFiled: July 22, 2004Date of Patent: September 5, 2006Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer
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Patent number: 7094584Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.Type: GrantFiled: March 19, 2004Date of Patent: August 22, 2006Assignee: Degussa AGInventors: Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Möckel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
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Patent number: 7083942Abstract: The invention relates to alleles of the aceA gene from coryneform bacteria coding for isocitrate lyases and processes for the fermentative production of L-lysine using bacteria that contain these alleles.Type: GrantFiled: March 7, 2003Date of Patent: August 1, 2006Assignee: Degussa AGInventors: Brigitte Bathe, Caroline Kreutzer, Stephan Hans
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Patent number: 7078502Abstract: Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the lysR2 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.Type: GrantFiled: April 6, 2001Date of Patent: July 18, 2006Assignee: Degussa AGInventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
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Publication number: 20060134761Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.Type: ApplicationFiled: December 27, 2004Publication date: June 22, 2006Applicant: DEGUSSA AGInventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
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Publication number: 20060019357Abstract: An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.Type: ApplicationFiled: August 5, 2005Publication date: January 26, 2006Applicant: DEGUSSA AGInventors: Bettina Moeckel, Brigitte Bathe, Stefan Hans, Caroline Kreutzer, Thomas Hermann, Walter Pfefferle, Michael Binder
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Publication number: 20050282259Abstract: Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the lysR2 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.Type: ApplicationFiled: July 12, 2005Publication date: December 22, 2005Applicant: Degussa AGInventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
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Patent number: 6939695Abstract: An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.Type: GrantFiled: February 15, 2002Date of Patent: September 6, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Brigitte Bathe, Stefan Hans, Caroline Kreutzer, Thomas Hermann, Walter Pfefferle, Michael Binder
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Patent number: 6902916Abstract: The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR1 transcriptional regulator activity.Type: GrantFiled: July 13, 2001Date of Patent: June 7, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
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Publication number: 20050112732Abstract: The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles.Type: ApplicationFiled: November 7, 2002Publication date: May 26, 2005Inventors: Brigitte Bathe, Stephan Hans, Caroline Kreutzer
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Patent number: 6890744Abstract: The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the sigD gene, and a host-vector system having a coryneform host bacterium in which the sigD gene is present in enhanced form and a vector which carries at least the sigD gene according to SEQ ID No: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.Type: GrantFiled: August 30, 2001Date of Patent: May 10, 2005Assignee: Degussa AGInventors: Brigitte Bathe, Caroline Kreutzer, Monika Martens, Mike Farwick, Thomas Hermann, Walter Pfefferle
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Publication number: 20050089976Abstract: The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.Type: ApplicationFiled: June 22, 2004Publication date: April 28, 2005Applicant: Degussa AGInventors: Bettina Moeckel, Mike Farwick, Thomas Hermann, Caroline Kreutzer, Walter Pfefferle
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Publication number: 20050074791Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.Type: ApplicationFiled: March 19, 2004Publication date: April 7, 2005Applicants: Degussa-Huls Aktiengesellachaft, Forschungszentrum Julich GmbHInventors: Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
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Patent number: 6875586Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity. The invention also relates to isolating the luxR gene and which encode a LuxR transcriptional activator from Corynebacterium glutamicum.Type: GrantFiled: July 13, 2001Date of Patent: April 5, 2005Assignee: Degussa AGInventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
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Patent number: 6861246Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced pyc gene (pyruvate carboxylase gene), in which strains additional genes, chosen from the group consisting of the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the lysE gene (lysine export carrier gene) and the dapB gene (dihydrodipicolinate reductase gene), but especially the dapA gene, are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.Type: GrantFiled: March 19, 2001Date of Patent: March 1, 2005Assignee: Degussa AGInventors: Caroline Kreutzer, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
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Publication number: 20050043526Abstract: The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles.Type: ApplicationFiled: October 16, 2002Publication date: February 24, 2005Inventors: Brigitte Bathe, Stephan Hans, Caroline Kreutzer, Walter Pfefferle
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Publication number: 20050032179Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is: a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, or b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, or c) polynucleotide which is complementary to the polynucleotides of a) or b), or d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ccpA1 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.Type: ApplicationFiled: July 22, 2004Publication date: February 10, 2005Applicant: DEGUSSA AGInventors: Bettina Moeckel, Caroline Kreutzer