Patents by Inventor Carsten Spanka

Carsten Spanka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl aminopropanol derivatives
    Patent number: 11932630
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: March 19, 2024
    Inventors: Andreas Kordikowski, Yugang Liu, Rainer Martin Lüönd, Christian Markert, Wolfgang Miltz, Till Roehn, Carsten Spanka, Gebhard Thoma, Tian Xie
  • PYRROLO[3,2-B]PYRIDINE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS
    Publication number: 20240051954
    Abstract: The present disclosure relates to a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein Ring A, and R1 through R4 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: December 20, 2021
    Publication date: February 15, 2024
    Inventors: David CARCACHE, Florian GRUBER, Danilo GUERINI, Martin GUNZENHAUSER, Richard HENG, Francesca PERRUCCIO, Oliver SIMIC, Carsten SPANKA
  • COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH cGAS
    Publication number: 20230085472
    Abstract: The present disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1 through R8 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: December 20, 2021
    Publication date: March 16, 2023
    Inventors: David CARCACHE, Florian GRUBER, Danilo GUERINI, Martin GUNZENHAUSER, Richard HENG, Francesca PERRUCCIO, Oliver SIMIC, Carsten SPANKA
  • Novel Heteroaryl Aminopropanol Derivatives
    Publication number: 20220348566
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: April 8, 2022
    Publication date: November 3, 2022
    Inventors: Andreas Kordikowski, Yugang Liu, Rainer Martin Lüönd, Christian Markert, Wolfgang Miltz, Till Roehn, Carsten Spanka, Gebhard Thoma, Tian XIE
  • Naphthyridinedione derivatives
    Publication number: 20190248784
    Abstract: The invention relates to compound of the formula (I?) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Application
    Filed: October 10, 2018
    Publication date: August 15, 2019
    Inventors: Juergen REINHARDT, Niko SCHMIEDEBERG, Carsten SPANKA
  • Naphthyridinedione derivatives
    Patent number: 10138232
    Abstract: The invention relates to compound of the formula (I?) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: November 27, 2018
    Assignee: NOVARTIS AG
    Inventors: Juergen Reinhardt, Niko Schmiedeberg, Carsten Spanka
  • Pyridopyrimidinedione derivatives
    Patent number: 9884862
    Abstract: The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: February 6, 2018
    Assignee: Novartis AG
    Inventors: Niko Schmiedeberg, Carsten Spanka
  • Pyrimido[4,5-b]quinoline-4,5(3H,10H)-diones
    Publication number: 20170266189
    Abstract: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Application
    Filed: April 4, 2017
    Publication date: September 21, 2017
    Inventors: Edgar JACOBY, Juergen REINHARDT, Niko SCHMIEDEBERG, Carsten SPANKA
  • Pyridopyrimidinedione derivatives
    Publication number: 20170197959
    Abstract: The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Application
    Filed: June 2, 2015
    Publication date: July 13, 2017
    Applicant: Novartis AG
    Inventors: Juergen REINHARDT, Niko SCHMIEDEBERG, Carsten SPANKA
  • Pyrimido[4,5-b]quinoline-4,5(3H,10H)-diones
    Patent number: 9649314
    Abstract: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: May 16, 2017
    Assignee: NOVARTIS AG
    Inventors: Edgar Jacoby, Juergen Reinhardt, Niko Schmiedeberg, Carsten Spanka
  • Naphthyridinedione derivatives
    Publication number: 20150344476
    Abstract: The invention relates to compound of the formula (I?) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Application
    Filed: June 2, 2015
    Publication date: December 3, 2015
    Applicant: NOVARTIS AG
    Inventors: Juergen REINHARDT, Niko SCHMIEDEBERG, Carsten SPANKA
  • Pyrimido[4,5-b]quinoline-4,5(3H,10H)-diones
    Publication number: 20150335646
    Abstract: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
    Type: Application
    Filed: December 12, 2013
    Publication date: November 26, 2015
    Applicant: NOVARTIS AG
    Inventors: Edgar JACOBY, Juergen INHARDT, Niko SCHMIEDEBERG, Carsten SPANKA
  • 3-Methyl-imidazo[1,2-b]pyridazine derivatives
    Patent number: 8822468
    Abstract: The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: September 2, 2014
    Assignee: Novartis AG
    Inventors: Pascal Furet, Clive McCarthy, Joseph Schoepfer, Carsten Spanka, Melanie Stang, Frederic Stauffer
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 8552002
    Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: October 8, 2013
    Assignees: Novartis AG, IRM LLC
    Inventors: Qiang Ding, Nathanael Schiander Gray, Bing Li, Yi Liu, Taebo Sim, Tetsuo Uno, Guobao Zhang, Carole Pissot Soldermann, Werner Breitenstein, Guido Bold, Giorgio Caravatti, Pascal Furet, Vito Guagnano, Marc Lang, Paul William Manley, Joseph Schoepfer, Carsten Spanka
  • Methods of identifying a modulator that inhibits the binding between Epstein-Barr virus induced receptor 2 and cholesterol derived ligands
    Patent number: 8497075
    Abstract: The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7,25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Grant
    Filed: July 12, 2009
    Date of Patent: July 30, 2013
    Assignees: Novartis AG, IRM LLC, Euroscreen SA, The Scripps Research Institute
    Inventors: Birgit Baumgarten, Francois Gessier, Andreas Katopodis, Richard Knochenmuss, Rocco Falchetto, Silvio Roggo, Andreas Sailer, Klaus Seuwen, Carsten Spanka, Juan Zhang, Sebastien Hannedouche, Sophie Noel, Marie-Odile Roy, Yu Chen, Charles Y. Cho, Wei Li, Weijun Shen
  • COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
    Publication number: 20130012476
    Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Inventors: Qiang DING, Nathanael Schiander GRAY, Bing LI, Yi LIU, Taebo SIM, Tetsuo UNO, Guobao ZHANG, Carole Pissot Soldermann, Werner BREITENSTEIN, Guido BOLD, Giorgio CARAVATTI, Pascal FURET, Vito GUAGNANO, Marc LANG, Paul W. MANLEY, Joseph SCHOEPFER, Carsten SPANKA
  • COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
    Publication number: 20130012704
    Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Inventors: Qiang DING, Nathanael Schiander GRAY, Bing LI, Yi LIU, Taebo SIM, Tetsuo UNO, Guobao ZHANG, Carole Pissot Soldermann, Werner BREITENSTEIN, Guido BOLD, Giorgio CARAVATTI, Pascal FURET, Vito GUAGNANO, Marc LANG, Paul W. MANLEY, Joseph SCHOEPFER, Carsten SPANKA
  • ORGANIC COMPOUNDS
    Publication number: 20110243923
    Abstract: The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7, 25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Application
    Filed: July 12, 2009
    Publication date: October 6, 2011
    Inventors: Birgit Baumgarten, Francois Gessier, Andreas Katopodis, Richard Knochenmuss, Rocco Falchetto, Silvio Roggo, Andreas Sailer, Klaus Seuwen, Carsten Spanka, Juan Zhang, Sebastien Hannedouche, Sophie Noel, Marie-Odile Roy, Yu Chen, Charles Y. Cho, Wei Li, Weijun Shen
  • HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2
    Publication number: 20110009429
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, X, Y and Z are as defined in the specification.
    Type: Application
    Filed: February 25, 2009
    Publication date: January 13, 2011
    Inventors: Paul Oakley, Neil John Press, Carsten Spanka, Simon James Watson
  • CXCR2 INHIBITORS
    Publication number: 20100152205
    Abstract: The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.
    Type: Application
    Filed: November 21, 2007
    Publication date: June 17, 2010
    Inventors: Peter Hunt, David Porter, Nell John Press, Carsten Spanka, Simon James Watson