Patents by Inventor Catherine E. Burgess
Catherine E. Burgess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7109000Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: GrantFiled: March 1, 2002Date of Patent: September 19, 2006Assignee: CuraGen CorporationInventors: Shlomit R. Edinger, John R. MacDougall, Isabelle Millet, Karen Ellerman, David J. Stone, Valerie Gerlach, William M. Grosse, John P. Alsobrook, II, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Stacie J. Casman, Kimberly A. Spytek, Ferenc L. Boldog, Li Li, Muralidhara Padigaru, Vishnu Mishra, Meera Patturajan, Suresh G. Shenoy, Luca Rastelli, Velizar T. Tchernev, Corine A. M. Vernet, Bryan D. Zerhusen, Uriel M. Malyankar, Xiaojia Guo, Charles E. Miller, Esha A. Gangolli
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Patent number: 6989232Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: GrantFiled: August 27, 2001Date of Patent: January 24, 2006Assignees: Millennium Pharmaceuticals, Inc., Curagen CorporationInventors: Catherine E. Burgess, Pamela B. Conley, William M. Grosse, Matthew Hart, Ramesh Kekuda, Richard A. Shimkets, Kimberly A. Spytek, Edward Szekeres, Jr., James E. Tomlinson, James N. Topper, Ruey-Bin Yang
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Patent number: 6974684Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: GrantFiled: August 1, 2002Date of Patent: December 13, 2005Assignee: CuraGen CorporationInventors: David W. Anderson, John P. Alsobrook II, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Shlomit R. Edinger, Esha A. Gangolli, Linda Gorman, Xiaojia Sasha Guo, Nikolai Khramtsov, Denise M. Lepley, John R. MacDougall, Carol E. A. Pena, John A. Peyman, Meera Patturajan, Daniel K. Rieger, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, Corine A. M. Vernet, Edward Z. Voss, Mei Zhong
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Patent number: 6875570Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: GrantFiled: September 26, 2001Date of Patent: April 5, 2005Assignee: CuraGen CorporationInventors: Valerie L. Gerlach, John R. MacDougall, Glennda Smithson, Isabelle Millet, David Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, II, Denise M. Lepley, Catherine E. Burgess, Muralidhara Padigaru, Ramesh Kekuda, Kimberly A. Spytek, Martin D. Leach, Richard A. Shimkets
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Publication number: 20040214759Abstract: In methods of using a fibroblast growth factor, such as for treating, preventing or delaying a proliferation-associated disorder, steps are provided to administer to a subject a therapeutically effective amount of a particular fibroblast growth factor polypeptide, or variant or fragment thereof.Type: ApplicationFiled: May 9, 2003Publication date: October 28, 2004Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Joel S. Bader, Ferenc L. Boldog, Catherine E. Burgess, Rajeev A. Chillakuru, Lisa Deegler, Shlomit R. Edinger, Elma R. Fernandes, Linda Gorman, William M. Grosse, John L. Herrmann, Michael E. Jeffers, William J. LaRochelle, Denise M. Lepley, Henri S. Lichenstein, Kumar Namdev, Muralidhara Padigaru, Carol E. A. Pena, Sudhirdas K. Prayaga, Daniel K. Rieger, Richard A. Shimkets, Pascal Valax, Meijia Yang, Zachary Yim, Mei Zhong
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Publication number: 20040096877Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: July 21, 2003Publication date: May 20, 2004Inventors: Raymond J. Taupier, Muralidhara Padigaru, Luca Rastelli, Steven Kurt Spaderna, Richard A. Shimkets, Bryan D. Zerhusen, Kimberly Ann Spytek, Suresh G. Shenoy, Li Li, Vladimir Y. Gusev, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Valerie L. Gerlach, Karen Ellerman, John R. MacDougall, David J. Stone, Glennda Smithson
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Publication number: 20040086875Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: November 4, 2002Publication date: May 6, 2004Inventors: Michele L. Agee, John P. Alsobrook, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Amitabha Chaudhuri, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Linda Gorman, Valerie Gerlach, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Li Li, Uriel M. Malyankar, John R. MacDougall, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Chean Eng. Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Steven K. Spaderna, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Bryan D. Zerhusen, Mei Zhong
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Publication number: 20040072997Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: January 3, 2003Publication date: April 15, 2004Inventors: John P. Alsobrook, David W. Anderson, Catherine E. Burgess, Shlomit R. Edinger, Karen Ellerman, Katarzyna Furtak, Esha A. Gangolli, Valerie Gerlach, Jennifer A. Gilbert, Erik Gunther, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Li Li, Charles E. Miller, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, John R. MacDougall, Vishnu Mishra, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Suresh G. Shenoy, Raymond J. Taupier, Corine A.M. Vernet, Mei Zhong, Uriel M. Malyankar, Isabelle Millet, Ramesh Kekuda, William M. Grosse
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Publication number: 20040068095Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: March 13, 2002Publication date: April 8, 2004Inventors: Richard A. Shimkets, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Peter S. Mezes, Luca Rastelli, Uriel M. Malyankar, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Kimberly Ann Spytek, Li Li, Shlomit Edinger, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Erik Gunther, Isabelle Millet, David J. Stone, Glennda Smithson, Edward S. Szekeres, Weizhen Ji
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Publication number: 20040067882Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: November 5, 2002Publication date: April 8, 2004Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong
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Publication number: 20040067490Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: September 6, 2002Publication date: April 8, 2004Inventors: Mei Zhong, Li Li, Linda Gorman, Kimberly A. Spytek, Ramesh Kekuda, Raymond J. Taupier, David W. Anderson, Corine A.M. Vernet, Elina Catterton, Charles E. Miller, Suresh G. Shenoy, Meera Patturajan, Carol E. A. Pena, Velizar T. Tchernev, Muralidhara Padigaru, Vladimir Y. Gusev, Uriel M. Malyankar, Catherine E. Burgess, Valerie Gerlach, Stacie J. Casman, Daniel K. Rieger, William M. Grosse, Glennda Smithson, John A. Peyman, Gary Starling, Mark E. Rothenberg, William J. LaRochelle, Richard A. Shimkets, Julie Crabtree, Luca Rastelli, Edward Z. Voss, Ferenc L. Boldog, Shlomit R. Edinger, Isabelle Millet, John R. MacDougall, Karen Ellerman, Andrei Chapoval
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Publication number: 20040058338Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: December 2, 2002Publication date: March 25, 2004Inventors: Michele L. Agee, John P. Alsobrook, David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Elina Catterton, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Bonnie Gould Rothberg, Xiaojia Sasha Guo, John L. Herrmann, Yuan-Di Halvorsen, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, William J. LaRochelle, Denise M. Lepley, Li Li, John R. MacDougall, Charles E. Miller, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong
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Publication number: 20040058347Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: March 5, 2003Publication date: March 25, 2004Inventors: John Alsobrook, Catherine E. Burgess, Shlomit R. Edinger, Valerie Gerlach, Weizhen Ji, Ramesh Kekuda, Li Li, John R. MacDougall, Charles E. Miller, Isabelle Millet, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Paul Sciore, Suresh G. Shenoy, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Edward Z. Voss, Mei Zhong
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Publication number: 20040052806Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: January 4, 2002Publication date: March 18, 2004Inventors: Ramesh Kekuda, John P. Alsobrook, Velizar T. Tchernev, Xiaohong Liu, Kimberly A. Spytek, Meera Patturajan, William M. Grosse, Denise M. Lepley, Catherine E. Burgess, Corine A.M. Vernet, Li Li, Linda Gorman, Shlomit R. Edinger, Paul Sciore, Karen Ellerman, Uriel M. Malyankar, Mark E. Rothenberg, David J. Stone, Ferenc L. Boldog, Xiaojia (Sasha) Guo, Suresh G. Shenoy, David W. Anderson, Muralidhara Padigaru, Raymond J. Taupier, Charles E. Miller, Andrew Eisen
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Publication number: 20040048245Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: October 5, 2001Publication date: March 11, 2004Inventors: Richard A. Shimkets, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Peter S. Mezes, Luca Rastelli, Uriel M. Malyankar, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Kimberly Ann Spytek, Li Li, Shlomit Edinger, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Erik Gunther, Isabelle Millet, David J. Stone, Glennda Smithson, Edward S. Szekeres
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Publication number: 20040048256Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: September 6, 2002Publication date: March 11, 2004Inventors: Michele L. Agee, John P. Alsobrook, David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Elina Catterton, John S. Chant, Amitabha Chaudhuri, Julie Bokor, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Loic Giot, Linda Gorman, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Martin D. Leach, Denise M. Lepley, Li Li, Xiaohong Liu, Uriel M. Malyankar, Charles E. Miller, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Steven K. Spaderna, Kimberly A. Spytek, Raymond J. Taupier, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
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Publication number: 20040043929Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: January 3, 2003Publication date: March 4, 2004Inventors: David W. Anderson, Robert A. Ballinger, Jason C. Baumgartner, Catherine E. Burgess, Stacie J. Casman, John S. Chant, Constance Berghs, Esha A. Gangolli, Shlomit R. Edinger, Karen Ellerman, Katarzyna Furtak, Valerie Gerlach, Jennifer A. Gilbert, Erik Gunther, Linda Gorman, Xiaojia Sasha Guo, Weizhen Ji, Li Li, Xiaohong Liu, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, John R. MacDougall, Vishnu Mishra, Carol E.A. Pena, Steven K. Spaderna, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Suresh G. Shenoy, Tatiana Ort, Raymond J. Taupier, Velizar T. Tchernev, Corine A.M. Vernet, Adam R. Wolenc, Bryan D. Zerhusen, Mei Zhong
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Publication number: 20040043926Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: September 26, 2001Publication date: March 4, 2004Inventors: Valerie L. Gerlach, John R. MacDougall, Glennda Smithson, Isabelle Millet, David Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Muralidhara Padigaru, Ramesh Kekuda, Kimberly A. Spytek, Martin D. Leach, Richard A. Shimkets
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Publication number: 20040043382Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.Type: ApplicationFiled: March 7, 2002Publication date: March 4, 2004Inventors: Muralidhara Padigaru, Kimberly A. Spytek, Suresh G. Shenoy, Raymond J. Taupier, Carol E. A. Pena, Li Li, Bryan D. Zerhusen, Vladimir Y. Gusev, Weizhen Ji, Linda Gorman, Charles E. Miller, Ramesh Kekuda, Meera Patturajan, Esha A. Gangolli, Corine A.M. Vernet, Xiaojia Sasha Guo, Velizar T. Tchernev, Elma R. Fernandes, Stacie J. Casman, Uriel M. Malyankar, Valerie Gerlach, Yi Liu, David W. Anderson, Steven K. Spaderna, Elina Catterton, Mario W. Leite, Haihong Zhong, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess
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Publication number: 20040043928Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: August 1, 2002Publication date: March 4, 2004Inventors: Ramesh Kekuda, Charles E. Miller, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Richard A. Shimkets, Bryan D. Zerhusen, Li Li, Weizhen Ji, Muralidhara Padigaru, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Linda Gorman, Mario W. Leite, Corine A.M. Vernet, David W. Anderson, Xiaojia Sasha Guo, Mei Zhong, Valerie Gerlach, Luca Rastelli, Tord Hjalt, Kimberly A. Spytek, Shlomit R. Edinger, Karen Ellerman, Uriel M. Malyankar, John R. MacDougall, David J. Stone, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Kumud Majumder, Adam R. Wolenc, Glennda Smithson, Jason C. Baumgartner