Patents by Inventor Catherine H. Schein

Catherine H. Schein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Physicochemical (PCP) based consensus sequences and uses thereof
    Patent number: 8900596
    Abstract: Provided herein is a computational method for designing a PCP-consensus protein for a family of related proteins. The method uses a consensus alignment of a protein domain common to all the related proteins, which may or may not be substantially biased, from which an average value of p, e.g., 5, physicochemical properties are calculated for each amino acid in the alignment. The PCP-consensus protein has a sequence derived from an alignment of protein domains from a family of related proteins, said sequence containing one or more motifs common to all of the proteins. Also provided are the PCP-consensus proteins, kits comprising the same, datasets of aligned consensus sequences used to derive the PCP-consensus proteins and methods of eliciting an immune response, diagnosing or treating an infectious disease using the same.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: December 2, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Catherine H. Schein, Petr Danecek
  • Physicochemical (PCP) Based Consensus Sequences and Uses Thereof
    Publication number: 20130071418
    Abstract: Provided herein is a computational method for designing a PCP-consensus protein for a family of related proteins. The method uses a consensus alignment of a protein domain common to all the related proteins, which may or may not be substantially biased, from which an average value of p, e.g., 5, physicochemical properties are calculated for each amino acid in the alignment. The PCP-consensus protein has a sequence derived from an alignment of protein domains from a family of related proteins, said sequence containing one or more motifs common to all of the proteins. Also provided are the PCP-consensus proteins, kits comprising the same, datasets of aligned consensus sequences used to derive the PCP-consensus proteins and methods of eliciting an immune response, diagnosing or treating an infectious disease using the same.
    Type: Application
    Filed: November 18, 2010
    Publication date: March 21, 2013
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Catherine H. Schein, Petr Danecek
  • METHODS AND COMPOSITIONS TO INHIBIT EDEMA FACTOR AND ADENYLYL CYCLASE
    Publication number: 20120010233
    Abstract: Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3?,5?-adenosine monophosphate. Specific compositions of the invention are also novel.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 12, 2012
    Applicants: Board of Regents, The University of Texas, Mission Pharmacal Co.
    Inventors: Catherine H. Schein, Scott R. Gilbertson, Johnny W. Peterson, Deliang Chen, Maria Esterlla-Jimenez, Mary A. Walter, Jian Gao
  • Methods and compositions to inhibit edema factor and adenylyl cyclase
    Patent number: 8003692
    Abstract: Fluorene-based molecules and their derivatives are described in compositions for the treatment of intestinal fluid loss.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: August 23, 2011
    Assignees: Board of Regents, The University of Texas System, Mission Pharmacal Co.
    Inventors: Catherine H. Schein, Johnny W. Peterson, Scott R. Gilbertson, Deliang Chen, Maria Estrella-Jimenez, Mary A. Walter, Jian Gao
  • Methods and Compositions to Inhibit Edema Factor and Adenylyl Cyclase
    Publication number: 20090093519
    Abstract: Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3?,5?-adenosine monophosphate. Specific compositions of the invention are also novel.
    Type: Application
    Filed: June 13, 2008
    Publication date: April 9, 2009
    Applicants: Mission Pharmacal Co., Board of Regents, The University of Texas System
    Inventors: Catherine H. Schein, Scott R. Gilbertson, Johnny W. Peterson, Deliang Chen, Maria Estrella-Jimenez, Mary A. Walter, Jian Gao
  • Physical-chemical property based sequence motifs and methods regarding same
    Patent number: 7424369
    Abstract: A data analysis system, program, and/or method, e.g., a data mining/data exploration method, using physical-chemical property motifs. For example, a sequence database may be searched for identifying segments thereof having physical-chemical properties similar to the physical-chemical property motifs.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: September 9, 2008
    Assignee: Board of Regents, The University of Texas System
    Inventors: Werner Braun, Venkatarajan S. Mathura, Catherine H. Schein