Patents by Inventor Chan-Kou Hwang

Chan-Kou Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20190062342
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: March 23, 2018
    Publication date: February 28, 2019
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20160280718
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: November 4, 2015
    Publication date: September 29, 2016
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • Antibacterial agents
    Patent number: 9200026
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 1, 2015
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • Asynthesis of ?-nucleosides
    Patent number: 8765933
    Abstract: A process of stereoselectively synthesizing ?-nucleoside, e.g., 2?-deoxy-2,2?-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R1, R2, R3, R4, and L as defined in the specification, with a nucleobase derivative in the presence of an oxidizing agent.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: July 1, 2014
    Assignee: PharmaEssentia Corp.
    Inventors: Chungsun Chien, Pin-Shu Chien, Chan-Kou Hwang
  • 18-membered macrocycles and analogs thereof
    Patent number: 8586551
    Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: November 19, 2013
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
  • 18-Membered Macrocycles and Analogs Thereof
    Publication number: 20130252913
    Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 26, 2013
    Applicant: Optimer Pharmaceuticals, Inc.
    Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
  • Antibacterial agents
    Patent number: 8343936
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: January 1, 2013
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Jonathan Duffield, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang
  • ASYNTHESIS OF B-NUCLEOSIDES
    Publication number: 20120259106
    Abstract: A process of stereoselectively synthesizing ?-nucleoside, e.g., 2?-deoxy-2,2?-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R1, R2, R3, R4, and L as defined in the specification, with a nucleobase derivative in the presence of an oxidizing agent.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 11, 2012
    Applicant: PharmaEssentia Corp.
    Inventors: Chungsun Chien, Pin-Shu Chien, Chan-Kou Hwang
  • Synthesis of ?-nucleosides
    Patent number: 8193339
    Abstract: This invention relates to a process of stereoselectively synthesizing a ?-nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R1, R2, and L are as defined in the specification, with a nucleobase derivative; and each of R3 and R4, independently, is H or fluoro.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: June 5, 2012
    Assignee: Pharmaessentia Corp.
    Inventors: Chi-Yuan Chu, Wei-Der Lee, Wensen Li, Chan Kou Hwang
  • Novel antibacterial agents
    Publication number: 20120071429
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Application
    Filed: July 26, 2011
    Publication date: March 22, 2012
    Inventors: Jonathan Duffield, Chan-Kou Hwang, Yoshitaka Ichikawa, Youe-Kong Shue
  • Antibacterial agents
    Patent number: 8012943
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: September 6, 2011
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Jonathan Duffield, Chan-Kou Hwang, Yoshitaka Ichikawa, Youe-Kong Shue
  • 18-Membered Macrocycles and Analogs Thereof
    Publication number: 20110166090
    Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
    Type: Application
    Filed: March 11, 2011
    Publication date: July 7, 2011
    Inventors: Youe-Kong SHUE, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
  • 18-membered macrocycles and analogs thereof
    Patent number: 7906489
    Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: March 15, 2011
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
  • 18-MEMBERED MACROCYCLES AND ANALOGS THEREOF
    Publication number: 20100009925
    Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
    Type: Application
    Filed: August 31, 2009
    Publication date: January 14, 2010
    Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
  • Antibacterial agents
    Patent number: 7601695
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: October 13, 2009
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, David Rabuka, Sulan Yao, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang
  • Synthesis of glycopeptides with superior pharmacokinetic properties
    Publication number: 20090247732
    Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
    Type: Application
    Filed: November 1, 2004
    Publication date: October 1, 2009
    Applicant: Optimer Pharmaceuticals, Inc.
    Inventors: Jonathan Duffield, Kenneth Marby, Sean O'Hare, Chan-Kou Hwang, Yoshitaka Ichikawa
  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20090209593
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: April 27, 2009
    Publication date: August 20, 2009
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, David Rabuka, Sulan Yao, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang
  • NOVEL SYNTHESIS OF BETA-NUCLEOSIDES
    Publication number: 20090124797
    Abstract: This invention relates to a process of stereoselectively synthesizing ?-nucleoside, e.g., 2?-deoxy-2,2?-difluorocytidine.
    Type: Application
    Filed: November 6, 2008
    Publication date: May 14, 2009
    Applicant: PharmaEssentia Corporation
    Inventors: Chi-Yuan Chu, Wei-Der Lee, Wensen Li, Chan Kou Hwang
  • 18-Membered macrocycles and analogs thereof
    Publication number: 20080269145
    Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
    Type: Application
    Filed: July 31, 2007
    Publication date: October 30, 2008
    Inventors: Youe-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
  • Novel antibacterial agents
    Publication number: 20060100164
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: March 5, 2004
    Publication date: May 11, 2006
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang, Alex Romero, Yu-Hung Chiu, David Rabuka