Patents by Inventor Chang Han Lee

Chang Han Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200102400
    Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds C1q, and optionally activating Fc receptors, but that is significantly reduced for binding to the inhibitory Fc?RIIb receptor. Furthermore, methods and compositions are provided for promoting complement dependent cytotoxicity (CDC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or a different non-Fc binding domain.
    Type: Application
    Filed: September 17, 2019
    Publication date: April 2, 2020
    Applicant: Research Development Foundation
    Inventors: George GEORGIOU, Chang-Han LEE
  • Patent number: 10526408
    Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: January 7, 2020
    Assignee: Research Development Foundation
    Inventors: George Georgiou, Chang-Han Lee
  • Publication number: 20200004077
    Abstract: A display device including: a display panel including a first area, a second area spaced apart from the first area, and a bent third area between the first and second areas; a first support film coupled to a bottom surface of the display panel and overlapping the first area; and a second support film coupled to the bottom surface of the display panel, overlapping the second area, and spaced apart from the first support film by a gap, the gap overlapping the third area, a top surface of the first support film facing the display panel and an inner side of the first support film form a first angle, a top surface of the second support film facing the display panel and an inner side of the second support film form a second angle, which is greater than the first angle, and the first support film includes a protruding pattern.
    Type: Application
    Filed: April 22, 2019
    Publication date: January 2, 2020
    Inventors: Chang Han LEE, Myung Hwan KIM, Sang Yeol KIM, Woo Hyun KIM, Hyo Jin KIM, Kyoung MIN, II, Tae Hyun SUNG, Se Joong SHIN, Ho Ryun CHUNG, Jae Cheol CHOI
  • Publication number: 20190341566
    Abstract: A display device includes a display panel, a support film, and a polymer layer. The display panel includes a display area comprising a first area that is bendable, and a non-display area adjacent to the display area. The support film is coupled to a bottom surface of the display panel. The support film includes a first groove overlapping with the first area. The polymer layer is disposed in the first groove. The polymer layer includes a material with higher flexibility than the support film. Angles formed by a top surface of the support film and inner sides of the support film defining the first groove are acute angles.
    Type: Application
    Filed: March 26, 2019
    Publication date: November 7, 2019
    Inventors: Chang Han LEE, Myung Hwan KIM, Sang Yeol KIM, Woo Hyun KIM, Hyo Jin KIM, Kyoung Il MIN, Tae Hyun SUNG, Se Joong SHIN, Ho Ryun CHUNG, Jae cheol CHOI
  • Patent number: 10457737
    Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds C1q, and optionally activating Fc receptors, but that is significantly reduced for binding to the inhibitory Fc?RIIb receptor. Furthermore, methods and compositions are provided for promoting complement dependent cytotoxicity (CDC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or a different non-Fc binding domain.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: October 29, 2019
    Assignee: Research Development Foundation
    Inventors: George Georgiou, Chang-Han Lee
  • Patent number: 10446945
    Abstract: A metal leaf spring structure of electrical connection terminal includes a main body. The main body has a base section defined with a first end and a second end. The first end is connected with a first section and a locating section. The second end is connected with a bight section and a reciprocally movable second section. The locating section has a head section and a tail section. The locating section is positioned in the reciprocally moving path of the second section to setup a moving endpoint of the second section. The metal leaf spring structure of electrical connection terminal improves the shortcomings of the conventional metal leaf spring that the conductive wire cannot be plugged into the terminal by a precise angle so that the metal leaf spring is over-bent to affect the pressing and securing effect.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 15, 2019
    Assignees: Switchlab Inc., Switchlab (Shanghai) Co., Ltd.
    Inventors: Chih-Yuan Wu, Chang Han Lee
  • Publication number: 20190048078
    Abstract: In some aspects, mutant or variant Fc domains are provided that exhibit increased binding to FcRn and increased half-life after administration in vivo. The Fc domain may be comprised in a glycosylated or aglycosylated antibody. Methods for using the mutant or variant Fc domains or polypeptides comprising the mutant or variant Fc domains are also provided.
    Type: Application
    Filed: August 11, 2018
    Publication date: February 14, 2019
    Inventors: George GEORGIOU, Chang-Han LEE, Tae Hyun KANG
  • Publication number: 20180342815
    Abstract: A metal leaf spring structure of electrical connection terminal includes a main body. The main body has a base section defined with a first end and a second end. The first end is connected with a first section and a locating section. The second end is connected with a bight section and a reciprocally movable second section. The locating section has a head section and a tail section. The locating section is positioned in the reciprocally moving path of the second section to setup a moving endpoint of the second section. The metal leaf spring structure of electrical connection terminal improves the shortcomings of the conventional metal leaf spring that the conductive wire cannot be plugged into the terminal by a precise angle so that the metal leaf spring is over-bent to affect the pressing and securing effect.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Inventors: CHIH-YUAN WU, CHANG HAN LEE
  • Publication number: 20180342817
    Abstract: A metal leaf spring structure of electrical connection terminal includes a main body. The main body has a base section defined with a first end and a second end. The first end is connected with a first section and a locating section. The second end is connected with a bight section and a reciprocally movable second section. The locating section is positioned in the reciprocally moving path of the second section to setup a moving endpoint of the second section. The metal leaf spring structure of electrical connection terminal improves the shortcomings of the conventional metal leaf spring that the conductive wire cannot be plugged into the terminal by a precise angle so that the metal leaf spring is over-bent to affect the pressing and securing effect.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: CHIH-YUAN WU, CHANG HAN LEE
  • Publication number: 20180342816
    Abstract: A metal leaf spring protection structure of electrical connection terminal includes a main body having a base section defined with a first end and a second end. The first end is connected with a first section and a locating section. The second end is connected with a bight section and a second section. The locating section has a head section and a tail section. The tail section extends to a position of the bight section to form a hook-like structure for providing an elastic action force and a support system. The locating section is positioned in the reciprocally moving path of the second section to set up a moving end point of the second section to improve the shortcomings of the conventional metal leaf spring that when plugging in the conductive wire, the metal leaf spring is over-bent to affect the pressing and securing effect.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: CHIH-YUAN WU, CHANG HAN LEE
  • Publication number: 20170058030
    Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Applicant: Research Development Foundation
    Inventors: George GEORGIOU, Chang-Han LEE
  • Publication number: 20160297886
    Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Clq, and optionally activating Fc receptors, but that is significantly reduced for binding to the inhibitory Fc?RIIb receptor. Furthermore, methods and compositions are provided for promoting complement dependent cytotoxicity (CDC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or a different non-Fc binding domain.
    Type: Application
    Filed: February 9, 2016
    Publication date: October 13, 2016
    Applicant: Research Development Foundation
    Inventors: George GEORGIOU, Chang-Han LEE
  • Publication number: 20150288640
    Abstract: A method of providing a notification by an electronic device is provided. The method includes initializing a first timer and a second timer that operate to control the notification; sensing at least one event; determining whether to restrict the notification of the at least one event based on a comparison of an occurrence time of the at least one event to a state of the second timer; and when the first timer expires, providing the notification of the at least one event which occurred after the initialization of the first timer and of which the notification is restricted by the second timer.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 8, 2015
    Inventor: Chang Han LEE
  • Patent number: 8492343
    Abstract: There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the structural scaffold of a Kringle domain; and protein scaffold variants, based on the Kringle domain structure, which modulate the biological activities of a variety of target molecules derived from the protein scaffold library by specifically binding to the target molecules. Also, there is provided a method for constructing homo-/hetero-oligomers which allow multi-specificity binding to multiple targets by the tandem assembly monomeric Kringle domain variants using a linker. Additionally, there is provided a method for preparing multispecific monomers and multivalent monomers by grafting target-binding loops of a Kringle domain variant into non-binding loops of another Kringle domain variant with the same or different target binding specificity.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: July 23, 2013
    Assignee: Ajou University Industry-Academic Cooperation Foundation
    Inventors: Yong-Sung Kim, Myung-Hee Kwon, Chang-Han Lee
  • Publication number: 20120021993
    Abstract: There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the structural scaffold of a Kringle domain; and protein scaffold variants, based on the Kringle domain structure, which modulate the biological activities of a variety of target molecules derived from the protein scaffold library by specifically binding to the target molecules. Also, there is provided a method for constructing homo-/hetero-oligomers which allow multi-specificity binding to multiple targets by the tandem assembly monomeric Kringle domain variants using a linker. Additionally, there is provided a method for preparing multispecific monomers and multivalent monomers by grafting target-binding loops of a Kringle domain variant into non-binding loops of another Kringle domain variant with the same or different target binding specificity.
    Type: Application
    Filed: August 7, 2009
    Publication date: January 26, 2012
    Inventors: Yong-Sung Kim, Myung-Hee Kwon, Chang-Han Lee
  • Patent number: 6638566
    Abstract: The present invention provides a method of manufacturing an electroconductive antireflection film and a glass faceplate having the film of high electroconductivity, excellent antireflection characteristics and electromagnetically shielding characteristic with very high sticking strength and film hardness, etc., and formed at the lower manufacturing cost and in the simple manufacturing method. The method comprises the steps of: dissolving in alcohol an aqueous solution of organic polymer containing polyethylenedioxythiophene which polystyrenesulphonate is doped to; adding silicon alkoxide to the alcoholic solution for reinforcing adhesion; preparing an organic polymeric electroconductive solution by adding pure water and a basic catalyst for hydrolysis; and applying the electroconductive solution on the image display glass plate, thereby forming the polymeric electroconductive film as an antireflective film.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: October 28, 2003
    Assignee: Orion Electric Co., Ltd.
    Inventor: Chang Han Lee
  • Patent number: 6630196
    Abstract: An image display faceplate and its manufacturing method wherein an electroconductive organic polymeric transparent anti-static film is formed on the image lay faceplate by the steps of obtaining an aqueous solution by solving electroconductive organic polymers in water, applying the solution and heat-treating the applied faceplate panel at a relatively low temperature, and the solution are disclosed. The aqueous solution is prepared by the steps of: dissolving in alcohol an aqueous solution of polyethylene dioxythiophene which polystyrene sulphonate is doped 3 to; first-adding silicon alkoxide to the alcoholic solution; and second-adding pure water and an inorganic acid catalyst for hydrolysis after the first adding step.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: October 7, 2003
    Assignee: Orion Electric Co., Ltd.
    Inventors: Sang Youl Yoon, Chang Han Lee, Ho Seok Shon
  • Patent number: 6391227
    Abstract: A glass plate having high-electroconductive film which can be formed using electroconductive organic polyrmer in a simple method and at a low cost, and having an improved anti-static characteristic with a strong film hardness and a strong adhesive strength. The glass plate has an anti-static film (10, 20) formed on the exterior surface, the film comprising a first coating layer (11, 21) formed containing an electroconductive organic polymeric component and a second coating layer (12, 22) of silica coating formed by being overcoated onto the first coating layer (11, 21). The electroconductive organic polymeric solution contains 0.005-0.5 wt. % of polyethylenedioxythiophene which polystyrenesulphonate is doped to and silicon alkoxide of below 10 wt. %, and also may contain 40-90 wt. % of at least one a selected from a group consisting of a methanol, an ethanol, an isopropanol, a butanol, and combinations thereof, 5-70 wt. % of pure water, and 1-20 wt.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: May 21, 2002
    Assignee: Orion Electric Co., Ltd.
    Inventors: Sang Youl Yoon, Chang Han Lee, Ho Seok Shon