Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.

Abstract: An integrated circuit (IC) includes circuitry configured to, drive a flash unit comprising at least one light-emitting device, by providing a supply voltage to the flash unit based on an external input power source or a battery, the supply voltage being provided along one of a plurality of different current paths corresponding to a plurality of operation states, no voltage being received from the external input power source in a first operation state among the plurality of operation states, a first voltage level being received from the external input power source in a second operation state among the plurality of operation states, and a second voltage level being received from the external input power source in a third operation state among the plurality of operation states, and charge the battery based on an charging voltage received from the external input power source.

Abstract: An integrated circuit (IC) includes circuitry configured to, drive a flash unit comprising at least one light-emitting device, by providing a supply voltage to the flash unit based on an external input power source or a battery, the supply voltage being provided along one of a plurality of different current paths corresponding to a plurality of operation states, no voltage being received from the external input power source in a first operation state among the plurality of operation states, a first voltage level being received from the external input power source in a second operation state among the plurality of operation states, and a second voltage level being received from the external input power source in a third operation state among the plurality of operation states, and charge the battery based on an charging voltage received from the external input power source.

Abstract: Provided is a method of estimating a load carrying capacity of a bridge. The load carrying capacity estimation method includes the steps of: estimating a mode coefficient of the bridge using an acceleration signal obtained from an accelerometer that is installed in the bridge; updating an analysis model of the bridge using the estimated mode coefficient; and estimating a rating factor of the bridge by applying a dead load and a design live load to the updated analysis model.

Abstract: Provided is a method of estimating a load carrying capacity of a bridge. The load carrying capacity estimation method includes the steps of: estimating a mode coefficient of the bridge using an acceleration signal obtained from an accelerometer that is installed in the bridge; updating an analysis model of the bridge using the estimated mode coefficient; and estimating a rating factor of the bridge by applying a dead load and a design live load to the updated analysis model.

Abstract: The present invention relates to a vaccine enhancing the protective immunity to Hepatitis C virus using plasmid DNA and recombinant adenovirus, more particularly to a vaccine consisting of ? core-E1-E2 expressing DNA vaccine, nonstructural protein NS3 and NS4 expressing DNA vaccine, nonstructural protein NS5 expressing DNA vaccine and recombinant adenovirus vaccine, and method for administration of the vaccine by priming with the DNA vaccines described above and boosting with the recombinant adenovirus vaccine thereby enhancing the protective immunity to Hepatitis C virus.

Abstract: A welding wire weaving apparatus for a submerged arc welding carriage includes a truck running in a welding direction, a control panel controlling parameters required for welding and weaving operations, a welding wire reel mounting a welding wire thereon, a welding wire supplier supplying the welding wire to an upper part of a member to be welded, a weaver unit weaving the welding wire transversely, a supplier supporting shaft supporting the welding wire supplier at an upper part of the truck, and a weaver unit connection bar connecting the weaver unit to the supplier supporting shaft. The welding wire supplier includes a supply guiding roller, a compressive supplying roller, a welding wire guide bundle, a needle bearing, a welding wire guide bundle and an insulator formed between the needle bearing and the welding wire guide bundle.

Abstract: Disclosed is a vaccine composition that includes a peptide adjuvant, and a DNA vaccine encoding an immunogenic protein. Also, the present invention discloses a method of enhancing immune responses, which is based on the administration of the vaccine composition.