Patents by Inventor Chaoguang Tian
Chaoguang Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230053729Abstract: The invention discloses a construction method of genetic engineering fungi of filamentous fungi. Through the genetic engineering method, the filamentous fungi overexpress the positive regulation genes of ethanol synthesis, and/or down regulate the negative regulation genes of endogenous ethanol synthesis to obtain genetic engineering strains. Or overexpression of acetaldehyde dehydrogenase and ethanol dehydrogenase containing mitochondrial localization signal sequence, or overexpression of pyruvate decarboxylase and ethanol dehydrogenase containing mitochondrial localization signal sequence, or overexpression of acetaldehyde dehydrogenase, ethanol dehydrogenase and pyruvate decarboxylase containing mitochondrial localization signal sequence in filamentous fungal cells. Compared with the original strain, the ethanol synthesis ability of the obtained genetically engineered strains are improved.Type: ApplicationFiled: December 9, 2020Publication date: February 23, 2023Inventors: Chaoguang TIAN, Yongli ZHANG, Jingen LI, Tao SUN, Qian LIU, Wenliang SUN
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Patent number: 11390890Abstract: Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved.Type: GrantFiled: July 20, 2020Date of Patent: July 19, 2022Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Chaoguang Tian, Jingen Li, Chuannan Long, Tao Sun, Liangcai Lin, Jing Xu, Qian Liu, Jingxiao Ji, Wenliang Sun, Yanhe Ma
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Publication number: 20210371844Abstract: The present invention provides a class of new mutant proteins for increasing malic acid yield. Specifically, the present invention provides a class of new pyruvate carboxylase mutant protein and malic acid transporter mutant proteins or combinations thereof, a preparation method therefor and use thereof in improving malic acid yield.Type: ApplicationFiled: October 18, 2019Publication date: December 2, 2021Applicant: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Chaoguang TIAN, Junqi ZHAO, Jingen LI, Lu ZHANG
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Publication number: 20200347415Abstract: Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved.Type: ApplicationFiled: July 20, 2020Publication date: November 5, 2020Inventors: Chaoguang TIAN, Jingen LI, Chuannan LONG, Tao SUN, Liangcai LIN, Jing XU, Qian LIU, Jingxiao JI, Wenliang SUN, Yanhe MA
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Patent number: 10781462Abstract: Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved.Type: GrantFiled: February 4, 2016Date of Patent: September 22, 2020Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Chaoguang Tian, Jingen Li, Chuannan Long, Tao Sun, Liangcai Lin, Jing Xu, Qian Liu, Jingxiao Ji, Wenliang Sun, Yanhe Ma
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Publication number: 20180171369Abstract: Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved.Type: ApplicationFiled: February 4, 2016Publication date: June 21, 2018Inventors: Chaoguang TIAN, Jingen LI, Chuannan LONG, Tao SUN, Liangcai LIN, Jing XU, Qian LIU, Jingxiao JI, Wenliang SUN, Yanhe MA
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Patent number: 9441255Abstract: Provided herein are methods and compositions for increasing the production of one or more cellulases from a fungal host cell. The disclosure is based, on the surprising discovery that mis-expression of the transcriptional regulator clr-2 in a filamentous fungal cell was able to induce expression of cellulase genes under non-inducing or starvation conditions, resulting in increased secretion of cellulases from the cell. Advantageously, mis-expression of the transcription factor clr-2 in a filamentous fungal cell cultured in the absence of cellulose or cellobiose results in increased secretion of cellulases.Type: GrantFiled: July 23, 2012Date of Patent: September 13, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Chaoguang Tian, Teresa Shock, N. Louise Glass, Samuel Coradetti, James Craig
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Publication number: 20150299755Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: ApplicationFiled: January 28, 2015Publication date: October 22, 2015Inventors: N. Louise GLASS, Chaoguang TIAN, William T. BEESON, IV, Huimin ZHAO, Jing DU, Jin Ho CHOI, James H. DOUDNA CATE, Jonathan M. GALAZKA, Suk-Jin HA, Yong-Su JIN, Soo Rin KIM, Sijin LI, Xiaomin YANG
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Patent number: 9012177Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: GrantFiled: May 28, 2014Date of Patent: April 21, 2015Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois, BP Corporation North America Inc.Inventors: N. Louise Glass, Chaoguang Tian, William T. Beeson, IV, Huimin Zhao, Jing Du, Jin Ho Choi, James H. Doudna Cate, Jonathan M. Galazka, Suk-Jin Ha, Yong-Su Jin, Soo Rin Kim, Sijin Li, Xiaomin Yang
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Publication number: 20150010985Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: ApplicationFiled: May 28, 2014Publication date: January 8, 2015Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The Board of Trustees of the University of Illinois, BP CORPORATION NORTH AMERICA INC.Inventors: N. Louise GLASS, Chaoguang TIAN, William T. BEESON, IV, Huimin ZHAO, Jing DU, Jin Ho CHOI, James H. DOUDNA CATE, Jonathan M. GALAZKA, Suk-Jin HA, Yong-Su JIN, Soo Rin KIM, Sijin LI, Xiaomin YANG
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Publication number: 20140220641Abstract: Provided herein are methods and compositions for increasing the production of one or more cellulases from a fungal host cell. The disclosure is based, on the surprising discovery that mis-expression of the transcriptional regulator clr-2 in a filamentous fungal cell was able to induce expression of cellulase genes under non-inducing or starvation conditions, resulting in increased secretion of cellulases from the cell. Advantageously, mis-expression of the transcription factor clr-2 in a filamentous fungal cell cultured in the absence of cellulose or cellobiose results in increased secretion of cellulases.Type: ApplicationFiled: July 23, 2012Publication date: August 7, 2014Applicant: The Regents of the University of CaliforniaInventors: Chaoguang Tian, Teresa Shock, N. Louise Glass, Samuel Coradetti, James Craig
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Patent number: 8765410Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: GrantFiled: March 13, 2013Date of Patent: July 1, 2014Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois, BP Corporation North America Inc.Inventors: N. Louise Glass, Chaoguang Tian, William T. Beeson, IV, Huimin Zhao, Jing Du, Jin Ho Choi, James H. Doudna Cate, Jonathan M. Galazka, Suk-Jin Ha, Yong-Su Jin, Soo Rin Kim, Sijin Li, Xiaomin Yang
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Publication number: 20130316437Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: ApplicationFiled: March 13, 2013Publication date: November 28, 2013Applicants: The Regents of the University of California, BP Corporation North America Inc., The Board of Trustees of the University of IllinoisInventors: N. Louise GLASS, Chaoguang Tian, William T. Beeson, Huimin Zhao, Jing Du, Jin Ho Choi, James H. Doudna Cate, Jonathan M. Galazka, Suk-Jin Ha, Yong-Su Jin, Soo Rin Kim, Sijin Li, Xiaomin Yang
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Patent number: 8431360Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: GrantFiled: July 26, 2010Date of Patent: April 30, 2013Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois, BP Corporation North America Inc.Inventors: N. Louise Glass, Chaoguang Tian, William T. Beeson, IV, Huimin Zhao, Jing Du, Jin Ho Choi, James H. Doudna Cate, Jonathan M. Galazka, Suk-Jin Ha, Yong-Su Jin, Soo Rin Kim, Sijin Li, Xiaomin Yang
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Publication number: 20110020910Abstract: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell.Type: ApplicationFiled: July 26, 2010Publication date: January 27, 2011Applicants: The Regents of the University of California, The Board of Trustees of the University of Illinois, British Petroleum Technology Ventures, Inc.Inventors: N.Louise C. GLASS, Chaoguang Tian, William T. Beeson, IV, Huimin Zhao, Jing Du, Jin Ho Choi, James H. Doudna Cate, Jonathan M. Galazka, Suk Jin Ha, Yong-Su Jin, Soo Rin Kim, Sijin Li, Xiaomin Yang