Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: A locking assembly of a lavatory door in an aircraft, comprising: a locking mechanism; and an occupancy indicator. The occupancy indicator is configured with a display that enables viewing of a status of the lavatory of availability or is occupancy. The position of the locking mechanism and occupancy indicator has been changed from a higher location on the lavatory door that approximates a line-of-sight from a standing position at the lavatory door to a lower location that approximates the line-of-sight from a seated position at the lavatory door. The display of the occupancy indicator is configured with a plurality of display angles to display the status comprising at least a first display angle to allow viewing from the line-of-sight in the standing position and at a second display angle to allow viewing from the line-of-sight in a seated lower position at the lavatory door.

Abstract: Systems and methods for vehicle message signing are provided. A method includes obtaining, by a vehicle computing system of an autonomous vehicle, a computing system state associated with the vehicle computing system and a message from at least one remote process running a computing device remote from the vehicle computing system. The message is associated with an intended recipient process running on the vehicle computing system. The method includes determining an originating sender for the message. The originating sender is indicative of a remote process that generated the message. The method includes determining a routing action for the message based on a comparison of the originating sender and the computing system state. The routing action includes at least one of a discarding action or a forwarding action to the intended recipient process. The method includes performing the routing action for the message.

Abstract: Systems and methods for vehicle message signing are provided. A method includes obtaining, by a vehicle computing system of an autonomous vehicle, a computing system state associated with the vehicle computing system and a message from at least one remote process running a computing device remote from the vehicle computing system. The message is associated with an intended recipient process running on the vehicle computing system. The method includes determining an originating sender for the message. The originating sender is indicative of a remote process that generated the message. The method includes determining a routing action for the message based on a comparison of the originating sender and the computing system state. The routing action includes at least one of a discarding action or a forwarding action to the intended recipient process. The method includes performing the routing action for the message.

Abstract: A method can include projecting one or more objects along one or more pre-determined trajectories toward a target zone, with each having a diameter less than a diameter of a regulation table tennis ball, the trainee attempting to prevent the one or more objects from entering the target zone and scoring the ability of the trainee. A method can include displaying a first video to a trainee that explains setup for a delivery device, setting up the delivery device based on the first video, projecting an object along a pre-determined trajectory toward a target zone proximate the trainee, wherein the object has a diameter that is less than a diameter of a regulation table tennis ball, and scoring an ability of the trainee to interact with the object at the target zone.

Abstract: A method can include determining physical characteristics of a trainee, adjusting a target zone based on the physical characteristics, adjusting one or more parameters of a delivery device based on the physical characteristics, projecting an object toward the target zone along a trajectory, and scoring a performance score of the trainee to track the object along a portion of the trajectory. A method can include projecting an object toward a target zone along a trajectory, a trainee attempting to impact the object at an appropriate location with a desired impact location of a sport tool, capturing imagery that contains the object at the appropriate location and the desired impact location of the sport tool, determining horizontal and vertical distances between the desired impact location and the object arriving at the appropriate location, and scoring a performance based on the horizontal and vertical distances.

Abstract: Systems and methods for onboard vehicle certificate distribution are provided. A system can include a plurality of devices including a master device for authenticating processes and one or more requesting devices. The master device can include a master host security service configured to authenticate the one or more processes of the system. The master host security service can run a certificate authority to generate a root certificate and a private root key corresponding to the root certificate. A respective host security service can receive a request for a process manifest for a requesting process of a respective device from a respective orchestration service. The respective host security service can generate the process manifest for the requesting process and provide the process manifest to the requesting process. The requesting process can use the process manifest to communicate with the certificate authority to obtain an operational certificate based on the root certificate.

Abstract: Systems and methods to authenticate a vehicle operator for an autonomous vehicle on a vehicle service platform are provided. In one example embodiment, a computer-implemented method includes obtaining authentication request data indicative of an authentication request, the authentication request data including at least an operator identifier associated with the vehicle operator and a vehicle identifier associated with the autonomous vehicle. The method includes providing a service code associated with the authentication request to the autonomous vehicle. The method includes obtaining from a user device in response to providing the service code to the autonomous vehicle, operator data associated with the authentication request, the operator data including the service code. The method includes determining an authentication result associated with the authentication request based at least in part on the service code and the operator data. The method includes providing the authentication result to the user device.

Abstract: Systems and methods for onboard vehicle certificate distribution are provided. A system can include a plurality of devices including a master device for authenticating processes and one or more requesting devices. The master device can include a master host security service configured to authenticate the one or more processes of the system. The master host security service can run a certificate authority to generate a root certificate and a private root key corresponding to the root certificate. A respective host security service can receive a request for a process manifest for a requesting process of a respective device from a respective orchestration service. The respective host security service can generate the process manifest for the requesting process and provide the process manifest to the requesting process. The requesting process can use the process manifest to communicate with the certificate authority to obtain an operational certificate based on the root certificate.

Abstract: Systems and methods to authenticate a vehicle operator for an autonomous vehicle on a vehicle service platform are provided. In one example embodiment, a computer-implemented method includes obtaining authentication request data indicative of an authentication request, the authentication request data including at least an operator identifier associated with the vehicle operator and a vehicle identifier associated with the autonomous vehicle. The method includes providing a service code associated with the authentication request to the autonomous vehicle. The method includes obtaining from a user device in response to providing the service code to the autonomous vehicle, operator data associated with the authentication request, the operator data including the service code. The method includes determining an authentication result associated with the authentication request based at least in part on the service code and the operator data. The method includes providing the authentication result to the user device.

Abstract: Systems and methods are directed to detecting tampering with a secured area of an autonomous vehicle. In one example, a computing system performs operations including generating a first key pair comprising a first private key and a first public key as part of a vehicle registration process; providing the first public key to one or more remote computing systems; determining whether a reset event occurred at a vehicle; in response to determining that the reset event occurred, discarding the first key pair and generating a second key pair comprising a second private key and a second public key; receiving a status query from one of the one or more remote computing systems; generating a response to the status query, the response being signed using either the first private key or the second private key; and providing the response to the one of the one or more remote computing systems.

Abstract: The present disclosure is directed to systems and methods associated with a communication infrastructure. The communication infrastructure includes a vehicle integration platform that includes a plurality of application programming interfaces configured to facilitate message communication among clients. The communication infrastructure includes a registration authority system configured to receive certificate signing requests from the clients and to generate client-specific credentials for establishing a predetermined time period of ability for client authentication within the vehicle integration platform. The communication infrastructure includes a certificate authority system configured to normalize requests received from the clients via the registration authority system such that the client-specific credentials are established according to an approved hierarchy of licensing certificates.

Abstract: A method for predicting pressures in an injection molding system for molding plastic parts requires providing a mold that has at least one channel with each additional channel having a constant cross-sectional shape along its length and each channel having different thicknesses with a constant cross-sectional shape along its length. At least one first sensor configured to collect pressure data from each channel is provided. At least three second sensors configured to detect the presence of plastic located at known distances downstream of the at least one first sensor. Molten plastic is injected in each of the channels and sensor data is collected for the molten plastic flowing through each channel. A curve is fitted to progressive measured occurrences of pressure at the first sensor when plastic is first detected at each of the second sensors for each channel. Pressure can be predicted for a given flow rate, temperature, and channel thickness at, between, or beyond the measured occurrences.

Abstract: Systems and methods are directed to improvements for secure communications between client systems and a vehicle integration platform associated with a service provider entity. In one example, a communication infrastructure is provided which includes a vehicle integration platform that includes a plurality of application programming interfaces configured to facilitate communication among clients. The communication infrastructure includes a security integration system which is configured to receive and validate a client certificate forwarded to the vehicle integration platform from a client and determine an identity of the client and an origin of a request associated with the client certificate.

Abstract: An apparatus and method for reducing the vibrations to a transition duct and improving the assembly and fit-up of a transition duct relative to a combustion system are disclosed. A damping member is provided between the transition duct and its mounting points to the gas turbine engine. The damping member comprises one or more layers of a composite material positioned between layers of sheet metal. An adjustable mounting system is also provided for the transition duct to allow for movement of a transition duct relative to the combustion liner.

Abstract: Systems and methods for servicing vehicle messages utilizing a common communications infrastructure are provided. A method includes obtaining, by a vehicle computing system onboard an autonomous vehicle, a message including a cryptographic signature and contextual information, a request, or a command. The method includes determining an originating sender associated with the message based on the cryptographic signature and determining a message privilege for the message based on the originating sender. The originating sender is a process that generated the message. The method includes determining a response for the contextual information, the request, or the command based on the message privilege. The response is indicative of an acceptance or rejection of contextual information, an assignment of computing resources to a request, or an acceptance or rejection of a command. The method includes performing a vehicle action based on the response.

Abstract: Systems and methods for onboard vehicle certificate distribution are provided. A system can include a plurality of devices including a master device for authenticating processes and one or more requesting devices. The master device can include a master host security service configured to authenticate the one or more processes of the system. The master host security service can run a certificate authority to generate a root certificate and a private root key corresponding to the root certificate. A respective host security service can receive a request for a process manifest for a requesting process of a respective device from a respective orchestration service. The respective host security service can generate the process manifest for the requesting process and provide the process manifest to the requesting process. The requesting process can use the process manifest to communicate with the certificate authority to obtain an operational certificate based on the root certificate.

Abstract: Systems and methods for vehicle message signing are provided. A method includes obtaining, by a vehicle computing system of an autonomous vehicle, a computing system state associated with the vehicle computing system and a message from at least one remote process running a computing device remote from the vehicle computing system. The message is associated with an intended recipient process running on the vehicle computing system. The method includes determining an originating sender for the message. The originating sender is indicative of a remote process that generated the message. The method includes determining a routing action for the message based on a comparison of the originating sender and the computing system state. The routing action includes at least one of a discarding action or a forwarding action to the intended recipient process. The method includes performing the routing action for the message.

Abstract: Systems and methods are directed to improvements for secure communications between client systems and a vehicle integration platform associated with a service provider entity. In one example, a communication infrastructure is provided which includes a vehicle integration platform that includes a plurality of application programming interfaces configured to facilitate communication among clients. The communication infrastructure includes a security integration system which is configured to receive and validate a client certificate forwarded to the vehicle integration platform from a client and determine an identity of the client and an origin of a request associated with the client certificate.

Abstract: A turbine nozzle having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, and within an envelope of approximately +/?0.049 inches, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form the airfoil shape. The X and Y values may also be scaled as a function of a first constant and the Z values may be scaled as a function of a second constant.