Patents by Inventor Charles A. Thornton

Charles A. Thornton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230272378
    Abstract: This invention relates to compositions and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the invention relate to polynucleotides, vectors, and host cells, and uses thereof.
    Type: Application
    Filed: June 7, 2021
    Publication date: August 31, 2023
    Applicant: University of Rochester
    Inventors: John D. Lueck, Joseph J. Porter, Charles A. Thornton, Wooree Ko
  • Publication number: 20230174987
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
    Type: Application
    Filed: July 21, 2022
    Publication date: June 8, 2023
    Applicants: Ionis Pharmaceuticals, Inc., University of Rochester
    Inventors: C. Frank Bennett, Susan M. Freier, Robert A. MacLeod, Sanjay K. Pandey, Charles A. Thornton, Thurman Wheeler, Seng H. Cheng, Andrew Leger, Bruce M. Wentworth
  • Publication number: 20200362353
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
    Type: Application
    Filed: December 20, 2019
    Publication date: November 19, 2020
    Applicants: Ionis Pharmaceuticals, Inc., University of Rochester
    Inventors: C. Frank Bennett, Susan M. Freier, Robert A. MacLeod, Sanjay K. Pandey, Charles A. Thornton, Thurman Wheeler, Seng H. Cheng, Andrew Leger, Bruce M. Wentworth
  • Publication number: 20180163209
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
    Type: Application
    Filed: July 24, 2017
    Publication date: June 14, 2018
    Applicants: Ionis Pharmaceuticals, Inc., University of Rochester
    Inventors: C. Frank Bennett, Susan M. Freier, Robert A. MacLeod, Sanjay K. Pandey, Charles A. Thornton, Thurman Wheeler, Seng H. Cheng, Andrew Leger, Bruce M. Wentworth
  • Patent number: 9765338
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 19, 2017
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: C. Frank Bennett, Susan M. Freier, Robert A. MacLeod, Sanjay K. Pandey, Charles A. Thornton, Thurman Wheeler, Seng H. Cheng, Andrew Leger, Bruce M. Wentworth
  • Patent number: 9371527
    Abstract: Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)exp or poly(CCUG)exp RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: June 21, 2016
    Assignee: University of Rochester
    Inventors: Charles A. Thornton, Thurman Wheeler, Krzysztof Sobczak, Robert Osborne, Jill Miller, Maurice Scott Swanson
  • Publication number: 20160068845
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
    Type: Application
    Filed: July 30, 2015
    Publication date: March 10, 2016
    Applicants: UNIVERSITY OF ROCHESTER, ISIS PHARMACEUTICALS, INC.
    Inventors: C. Frank Bennett, Susan M. Freier, Robert A. MacLeod, Sanjay K. Pandey, Charles A. Thornton, Thurman Wheeler, Seng H. Cheng, Andrew Leger, Bruce M. Wentworth
  • Patent number: 9256732
    Abstract: A smart card comprising a data store and a processor, said smart card being operable to connect with a host data processing apparatus, said smart card comprising authentication logic operable when connected to said host data processing apparatus to identify a secure data processing domain having predetermined properties within said host data processing apparatus and in response to identify said secure data processing domain, said smart card is operable to delegate at least some data processing operations to be processed within said secure data processing domain of said host data processing apparatus.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: February 9, 2016
    Assignee: ARM Limited
    Inventors: Peter William Harris, Peter Brian Wilson, Timothy Charles Thornton, David Paul Martin
  • Patent number: 9212205
    Abstract: The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: December 15, 2015
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter C. Gareiss, Joseph Wedekind, Charles Thornton, Krzysztof Sobczak
  • Publication number: 20150080452
    Abstract: Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)exp or poly(CCUG)exp RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.
    Type: Application
    Filed: June 5, 2014
    Publication date: March 19, 2015
    Inventors: Charles A. Thornton, Thurman Wheeler, Krzysztof Sobczak, Robert Osborne, Jill Miller, Maurice Scott Swanson
  • Patent number: 8561169
    Abstract: A data processing apparatus and method are provided for managing access to a display buffer. The data processing apparatus has a display buffer for storing an array of display elements for subsequent output to a display controller, with each display element having a security permission indication associated therewith identifying whether that display element is a secure display element or a non-secure display element. At least one processing unit is provided for executing a non-secure process and a secure process, each process issuing access requests when seeking to access display elements in the display buffer, and each access request specifying a location in the display buffer. Interface logic is associated with the display buffer for receiving each access request and is arranged for at least each access request issued by the non-secure process to determine the security permission indication associated with the display element currently stored at the location specified by that access request.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 15, 2013
    Assignee: ARM Limited
    Inventors: Peter William Harris, Peter Brian Wilson, David Paul Martin, Timothy Charles Thornton
  • Publication number: 20130237585
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
    Type: Application
    Filed: July 19, 2011
    Publication date: September 12, 2013
    Applicants: UNIVERSITY OF ROCHESTER, ISIS PHARMACEUTICALS, INC.
    Inventors: C. Frank Bennett, Susan M. Freier, Robert A. MacLeod, Sanjay K. Pandey, Charles A. Thornton, Thurman Wheeler, Seng H. Cheng, Andrew Leger, Bruce M. Wentworth
  • Patent number: 7964570
    Abstract: The present invention provides methods and compositions for the treatment of diseases associated with aberrant microsatellite expansions. Methods of the present invention comprise the use of recombinant adeno-associated virus vectors containing a transgene encoding at least one muscleblind protein. The present invention also provides an animal model for a disease associated with aberrant microsatellite expansion.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: June 21, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Maurice S. Swanson, Rahul N. Kanadia, Charles A. Thornton
  • Publication number: 20100266677
    Abstract: The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.
    Type: Application
    Filed: July 28, 2008
    Publication date: October 21, 2010
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter C. Gareiss, Joseph Wedekind, Charles Thornton, Krzysztof Sobczak
  • Publication number: 20100190689
    Abstract: Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)exp or poly(CCUG)exp RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.
    Type: Application
    Filed: September 21, 2007
    Publication date: July 29, 2010
    Applicants: University of Rochester, University of Florida Research Foundation, Inc.
    Inventors: Charles A. Thornton, Thurman Wheeler, Krzysztof Sobezak, Robert Osborne, Jill Miller, Maurice Swanson
  • Publication number: 20080213182
    Abstract: The present invention provides methods and compositions for the treatment of diseases associated with aberrant microsatellite expansions. Methods of the present invention comprise the use of recombinant adeno-associated virus vectors containing a transgene encoding at least one muscleblind protein. The present invention also provides an animal model for a disease associated with aberrant microsatellite expansion.
    Type: Application
    Filed: March 10, 2005
    Publication date: September 4, 2008
    Applicant: UNIVERSITY OF FLORIDA RESEARCH AND GRADUATE PROGRAMS
    Inventors: Maurice S. Swanson, Rahul N. Kanadia, Charles A. Thornton
  • Publication number: 20080163368
    Abstract: A data processing apparatus and method are provided for managing access to a display buffer. The data processing apparatus has a display buffer for storing an array of display elements for subsequent output to a display controller, with each display element having a security permission indication associated therewith identifying whether that display element is a secure display element or a non-secure display element. At least one processing unit is provided for executing a non-secure process and a secure process, each process issuing access requests when seeking to access display elements in the display buffer, and each access request specifying a location in the display buffer. Interface logic is associated with the display buffer for receiving each access request and is arranged for at least each access request issued by the non-secure process to determine the security permission indication associated with the display element currently stored at the location specified by that access request.
    Type: Application
    Filed: December 5, 2007
    Publication date: July 3, 2008
    Applicant: ARM LIMITED
    Inventors: Peter William Harris, Peter Brian Wilson, David Paul Martin, Timothy Charles Thornton
  • Publication number: 20080128494
    Abstract: A smart card comprising a data store and a processor, said smart card being operable to connect with a host data processing apparatus, said smart card comprising authentication logic operable when connected to said host data processing apparatus to identify a secure data processing domain having predetermined properties within said host data processing apparatus and in response to identifying said secure data processing domain, said smart card is operable to delegate at least some data processing operations to be processed within said secure data processing domain of said host data processing apparatus.
    Type: Application
    Filed: November 1, 2007
    Publication date: June 5, 2008
    Inventors: Peter William Harris, Peter Brian Wilson, Timothy Charles Thornton, David Paul Martin
  • Publication number: 20070269843
    Abstract: The present invention provides a method for a rapid and efficient mycobacteriophage-based diagnostic assay for the presence of microbacteria that have mycolic-acid structures in their outer membranes, such as mycobacteria, using betaine-like detergents.
    Type: Application
    Filed: April 25, 2005
    Publication date: November 22, 2007
    Inventor: Charles Thornton
  • Patent number: D1013096
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: January 30, 2024
    Assignee: Cast Products, Inc.
    Inventors: Colin McMurry, Colby Medlen, Charles Thornton