Patents by Inventor Charles I. Rosenblum

Charles I. Rosenblum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR MEASURING MITOCHONDRIAL MEMBRANE POTENTIAL IN VERTEBRATE CELLS
    Publication number: 20100209960
    Abstract: The present invention relates to homogenous fluorescence-based assays for measuring mitochondrial membrane potential in vertebrate cells. The assays use an inner filter such as Brilliant Black BN to quench non-specific fluorescence. The assays are particularly suited for ultra high-throughput screening for activators of mitochondrial uncoupling proteins, chemical uncouplers, compounds with mitochondrial toxicity, and compounds which stimulate mitochondrial biogenesis.
    Type: Application
    Filed: September 8, 2008
    Publication date: August 19, 2010
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Charles I. Rosenblum, Aurawan Vongs, Douglas MacNeil, Rebecca Mull
  • Leptin assay
    Patent number: 6007998
    Abstract: A trans-activation assay for leptin is described. Leptin response elements are located proximal to a promoter, and the promoter region is operatively linked to a reporter gene. When leptin binds with the receptor, the reporter gene is transcribed.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: December 28, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Charles I. Rosenblum, Leonardus H. T. Van Der Ploeg, Sajjad A. Qureshi, Doris F. Cully, John W. Hess, Michael R. Tota, Fang Chen