Patents by Inventor Charles J. Guinosso

Charles J. Guinosso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7297704
    Abstract: The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: November 20, 2007
    Assignee: Wyeth
    Inventors: Annmarie Louise Sabb, Robert Lewis Vogel, Gary Paul Stack, Deborah Ann Evrard, Amedeo Arturo Failli, Lalitha Krishnan, Anita Wai-Yin Chan, Jianxin Ren, Charles J. Guinosso, Reinhardt Bernhard Baudy, Jean Yi-ching Sze, Yanfang Li, Charles John Stanton, III, Antonia Nikitenko
  • Patent number: 7037646
    Abstract: Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the alkylamino group.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: May 2, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Charles J. Guinosso
  • Patent number: 6900297
    Abstract: Nucleotides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleotides through the alkylamino group.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 31, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Charles J. Guinosso
  • Patent number: 6783931
    Abstract: Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steriods, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosided through the alkylamino group.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: August 31, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Charles J. Guinosso
  • Publication number: 20040110717
    Abstract: The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
    Type: Application
    Filed: January 16, 2004
    Publication date: June 10, 2004
    Inventors: Steven S. Carroll, Robert L. LaFemina, Dawn L. Hall, Amy L. Himmelberger, Lawrence C. Kuo, David B. Olsen, Carrie A. Rutkowski, Joanne E. Tomassini, Malcolm MacCoss, Haoyun An, Balkrishen Bhat, Neelima Bhat, Phillip Dan Cook, Anne B. Eldrup, Thazha P. Prakash, Marija Prhavc, Charles J. Guinosso
  • Patent number: 6653458
    Abstract: Modified oligonucleotides containing at least one 2′,5′-internucleotide linkage are provided. The oligonucleotides of the invention may also bear additional substituents at the 2′- and 3′-positions.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: November 25, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Phillip Dan Cook, Charles J. Guinosso
  • Patent number: 6207826
    Abstract: Novel macrocyclic compounds are constructed to include a ring or ring system having two bridgehead atoms with a bridge extending between the bridgehead atoms. Located in at least the bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring or ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: March 27, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Charles J. Guinosso, Pei-Pei Kung, Allister S. Fraser
  • Patent number: 6107482
    Abstract: Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or more ring systems thereby forming a large cyclic structure. Located in each bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the macrocyclic compounds. In accordance with certain embodiments of the invention, libraries of such macrocyclic compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: August 22, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Haoyun An, Charles J. Guinosso, Pei-Pei Kung, Allister S. Fraser
  • Patent number: 5514786
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: May 7, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip D. Cook, Thomas Bruice, Charles J. Guinosso, Andrew M. Kawasaki
  • Patent number: 5359051
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. In preferred embodiments, the reactive portions comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with and without intervening intercalating moieties and act through phosphorodiester hydrolytic bond cleavage. Therapeutics, diagnostics and research methods are also disclosed. Synthetic nucleosides and nucleoside fragments are also provided which are useful for elaboration of oligonucleotides for such purposes.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: October 25, 1994
    Assignee: ISIS Pharmaceuticals
    Inventors: Phillip D. Cook, Charles J. Guinosso, Thomas Bruice
  • Patent number: 5218105
    Abstract: Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides targeted at the tat region of HIV comprise certain preferred embodiments.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: June 8, 1993
    Assignee: ISIS Pharmaceuticals
    Inventors: Philip D. Cook, Charles J. Guinosso
  • Patent number: 5138045
    Abstract: Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides targeted at the tat region of HIV comprise certain preferred embodiments.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: August 11, 1992
    Assignee: ISIS Pharmaceuticals
    Inventors: Philip D. Cook, Charles J. Guinosso
  • Patent number: 4535168
    Abstract: Disclosed herein is a process for preparing indoline-2-carboxylic acids from the corresponding indole-2-carboxylic acid or ester in which the indole-2-carboxylic acid or ester is first reduced to the indoline-2-carboxylic acid ester tin complex using stannous chloride and dry hydrogen chloride gas in a lower alkanol solvent at atmospheric pressures; and the resulting tin complex, dissolved in a lower alkanol, is converted directly to the free indoline-2-carboxylic acid by treatment with aqueous potassium or sodium hydroxide. The aqueous hydroxide treatment may take place in situ or after first isolating the intermediate indoline-2-carboxylic acid ester tin complex.
    Type: Grant
    Filed: February 3, 1983
    Date of Patent: August 13, 1985
    Assignee: American Home Products Corporation
    Inventor: Charles J. Guinosso
  • Patent number: 4209528
    Abstract: Variously substituted oxanilic acid esters possessing anti-secretory activity are useful anti-ulcer agents.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: June 24, 1980
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Dieter H. Klaubert, David A. Shriver
  • Patent number: 4191840
    Abstract: Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-napthtyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals;and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 7, 1979
    Date of Patent: March 4, 1980
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4160100
    Abstract: Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: July 3, 1979
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4154961
    Abstract: Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals;And pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: May 15, 1979
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4137325
    Abstract: Variously substituted oxanilic acid esters possessing anti-secretary activity are useful anti-ulcer agents.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: January 30, 1979
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, David A. Shriver, Dieter H. Klaubert
  • Patent number: 4112106
    Abstract: Anti-allergic agents of N-(2-thiazolyl)-1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower)alkyl amino, di(lower) alkylamino, polyhalo(lower)alkyl, halo and carbamoyl;Or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 15, 1977
    Date of Patent: September 5, 1978
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4112101
    Abstract: Anti-allergic agents of N-(pyridyl)-1H-(or 2H) Tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R is --H or lower alkyl;R.sup.2 is --H, lower alkoxy, --CN, di(lower) alkylamino, halo or polyhalo(lower) alkyl;Or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 15, 1977
    Date of Patent: September 5, 1978
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany